CL2013003042A1 - Compuestos derivados metilamina de biciclos sustituidos, moduladores de receptores de esfingosin-1- fosfato; composicion farmaceutica; y un metodo de tratamiento para tratar enfermedades oculares, degeneracion macular, retinopatia, entre otros - Google Patents
Compuestos derivados metilamina de biciclos sustituidos, moduladores de receptores de esfingosin-1- fosfato; composicion farmaceutica; y un metodo de tratamiento para tratar enfermedades oculares, degeneracion macular, retinopatia, entre otrosInfo
- Publication number
- CL2013003042A1 CL2013003042A1 CL2013003042A CL2013003042A CL2013003042A1 CL 2013003042 A1 CL2013003042 A1 CL 2013003042A1 CL 2013003042 A CL2013003042 A CL 2013003042A CL 2013003042 A CL2013003042 A CL 2013003042A CL 2013003042 A1 CL2013003042 A1 CL 2013003042A1
- Authority
- CL
- Chile
- Prior art keywords
- sphingosine
- retinopathy
- methylamine
- treatment
- pharmaceutical composition
- Prior art date
Links
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 title 2
- 208000017442 Retinal disease Diseases 0.000 title 1
- 206010038923 Retinopathy Diseases 0.000 title 1
- 229940127530 Sphingosine 1-Phosphate Receptor Modulators Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000030533 eye disease Diseases 0.000 title 1
- 208000002780 macular degeneration Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3834—Aromatic acids (P-C aromatic linkage)
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- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
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- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
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- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
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- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201161476367P | 2011-04-18 | 2011-04-18 |
Publications (1)
Publication Number | Publication Date |
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CL2013003042A1 true CL2013003042A1 (es) | 2014-04-04 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2013003042A CL2013003042A1 (es) | 2011-04-18 | 2013-10-18 | Compuestos derivados metilamina de biciclos sustituidos, moduladores de receptores de esfingosin-1- fosfato; composicion farmaceutica; y un metodo de tratamiento para tratar enfermedades oculares, degeneracion macular, retinopatia, entre otros |
Country Status (14)
Country | Link |
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US (2) | US8513418B2 (es) |
EP (1) | EP2699549A1 (es) |
JP (1) | JP2014518554A (es) |
KR (1) | KR20140048875A (es) |
CN (1) | CN103781766A (es) |
AU (1) | AU2012245683A1 (es) |
BR (1) | BR112013026807A2 (es) |
CA (1) | CA2833545A1 (es) |
CL (1) | CL2013003042A1 (es) |
IL (1) | IL228945A0 (es) |
MX (1) | MX2013012211A (es) |
RU (1) | RU2013150332A (es) |
SG (1) | SG194209A1 (es) |
WO (1) | WO2012145236A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2013150173A (ru) * | 2011-04-14 | 2015-05-20 | Аллерган, Инк. | Метиламинные производные бициклического фенила как модуляторы рецепторов сфингозин-1-фосфата |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
JP2016510000A (ja) | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
WO2014138075A1 (en) * | 2013-03-07 | 2014-09-12 | Allergan, Inc. | Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators |
WO2014175287A1 (ja) | 2013-04-26 | 2014-10-30 | 国立大学法人 京都大学 | 脳動脈瘤の形成および/または増大の抑制若しくは縮小用医薬組成物 |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CA2928658A1 (en) | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
RU2667649C2 (ru) | 2014-07-07 | 2018-09-21 | Мерил Лайф Сайенсиз Пвт. Лтд. | Стент с тонкими каркасными элементами из биорассасывающегося полимера с высокой усталостной и радиальной прочностью и способ его изготовления |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
AU2017324251A1 (en) | 2016-09-08 | 2019-03-21 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US20210113529A1 (en) | 2018-02-02 | 2021-04-22 | Kyoto University | Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability |
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JP4709488B2 (ja) * | 2002-01-18 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Edg受容体作動薬としてのN−(ベンジル)アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類 |
WO2003061567A2 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Selective s1p1/edg1 receptor agonists |
CA2524048C (en) | 2003-05-19 | 2013-06-25 | Irm Llc | Immunosuppressant compounds and compositions |
KR20110140139A (ko) * | 2003-08-29 | 2011-12-30 | 오노 야꾸힝 고교 가부시키가이샤 | S1p 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
CA2591399C (en) * | 2004-12-13 | 2014-05-20 | Ono Pharmaceutical Co., Ltd. | Aminocarboxylic acid derivative and medicinal use thereof |
CN101119714A (zh) * | 2005-02-14 | 2008-02-06 | 弗吉尼亚大学专利基金会 | 含有由氨基和苯基取代的环烷基和5元杂环的1-磷酸鞘氨醇激动剂 |
CN101460458A (zh) * | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1-磷酸-鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚-3-羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
WO2008018427A1 (fr) * | 2006-08-08 | 2008-02-14 | Kyorin Pharmaceutical Co., Ltd. | Dérivé d'ester de l'acide aminophosphorique et modulateur du récepteur s1p contenant ledit dérivé en tant que principe actif |
RU2010112275A (ru) * | 2007-09-24 | 2011-11-10 | Аллерган, Инк. (Us) | Индольные соединения, содержащие арильные или гетероарильные группы, обладющие биологической активностью рецептора сфингозин-1-фосфата (с1ф) |
RU2490266C2 (ru) * | 2008-12-05 | 2013-08-20 | Астеллас Фарма Инк. | Соединение 2н-хромена и его производное |
-
2012
- 2012-04-13 SG SG2013077409A patent/SG194209A1/en unknown
- 2012-04-13 EP EP12715303.9A patent/EP2699549A1/en not_active Withdrawn
- 2012-04-13 WO PCT/US2012/033459 patent/WO2012145236A1/en active Application Filing
- 2012-04-13 JP JP2014506463A patent/JP2014518554A/ja active Pending
- 2012-04-13 KR KR1020137030313A patent/KR20140048875A/ko not_active Application Discontinuation
- 2012-04-13 CA CA2833545A patent/CA2833545A1/en not_active Abandoned
- 2012-04-13 AU AU2012245683A patent/AU2012245683A1/en not_active Abandoned
- 2012-04-13 MX MX2013012211A patent/MX2013012211A/es not_active Application Discontinuation
- 2012-04-13 CN CN201280028761.7A patent/CN103781766A/zh active Pending
- 2012-04-13 BR BR112013026807A patent/BR112013026807A2/pt not_active IP Right Cessation
- 2012-04-13 RU RU2013150332/04A patent/RU2013150332A/ru not_active Application Discontinuation
- 2012-04-13 US US13/445,991 patent/US8513418B2/en not_active Expired - Fee Related
-
2013
- 2013-07-16 US US13/943,166 patent/US8658623B2/en not_active Expired - Fee Related
- 2013-10-17 IL IL228945A patent/IL228945A0/en unknown
- 2013-10-18 CL CL2013003042A patent/CL2013003042A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2013012211A (es) | 2013-12-09 |
CA2833545A1 (en) | 2012-10-26 |
JP2014518554A (ja) | 2014-07-31 |
RU2013150332A (ru) | 2015-05-27 |
WO2012145236A1 (en) | 2012-10-26 |
EP2699549A1 (en) | 2014-02-26 |
KR20140048875A (ko) | 2014-04-24 |
SG194209A1 (en) | 2013-11-29 |
US20130338109A1 (en) | 2013-12-19 |
US8658623B2 (en) | 2014-02-25 |
AU2012245683A1 (en) | 2013-11-07 |
CN103781766A (zh) | 2014-05-07 |
BR112013026807A2 (pt) | 2017-01-10 |
US8513418B2 (en) | 2013-08-20 |
US20120264715A1 (en) | 2012-10-18 |
IL228945A0 (en) | 2013-12-31 |
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