CL2013000788A1 - Compuestos derivados de 1,2,4-oxadiazol, inhibidores de la proteina activadora de 5-lipoxigenasa (flap); composicion farmaceutica; metodo de tratamiento; y uso para el tratamiento de un trastorno mediado por leucotrienos tal como enfermedades cardiovasculares, inflamatorias, alergicas, pulmonares y fibroticas, renales y cancer. - Google Patents

Compuestos derivados de 1,2,4-oxadiazol, inhibidores de la proteina activadora de 5-lipoxigenasa (flap); composicion farmaceutica; metodo de tratamiento; y uso para el tratamiento de un trastorno mediado por leucotrienos tal como enfermedades cardiovasculares, inflamatorias, alergicas, pulmonares y fibroticas, renales y cancer.

Info

Publication number
CL2013000788A1
CL2013000788A1 CL2013000788A CL2013000788A CL2013000788A1 CL 2013000788 A1 CL2013000788 A1 CL 2013000788A1 CL 2013000788 A CL2013000788 A CL 2013000788A CL 2013000788 A CL2013000788 A CL 2013000788A CL 2013000788 A1 CL2013000788 A1 CL 2013000788A1
Authority
CL
Chile
Prior art keywords
treatment
leukotriene
fibrotic
oxadiazole
allergic
Prior art date
Application number
CL2013000788A
Other languages
English (en)
Spanish (es)
Inventor
Alessandra Bartolozzi
Todd Bosanac
Lombaert Stephane De
John D Huber
Pui Leng Loke
Weimin Liu
Alan Olague
Doris Riether
Heather Tye
Lifen Wu
Zhindong Chen
Jonathon Alan Dines
Tina Marie Morwick
Renee M Zindell
Original Assignee
Boheringer Ingelheim Internat Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44720163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013000788(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boheringer Ingelheim Internat Gmbh filed Critical Boheringer Ingelheim Internat Gmbh
Publication of CL2013000788A1 publication Critical patent/CL2013000788A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CL2013000788A 2010-09-23 2013-03-21 Compuestos derivados de 1,2,4-oxadiazol, inhibidores de la proteina activadora de 5-lipoxigenasa (flap); composicion farmaceutica; metodo de tratamiento; y uso para el tratamiento de un trastorno mediado por leucotrienos tal como enfermedades cardiovasculares, inflamatorias, alergicas, pulmonares y fibroticas, renales y cancer. CL2013000788A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38573310P 2010-09-23 2010-09-23
US201161533349P 2011-09-12 2011-09-12

Publications (1)

Publication Number Publication Date
CL2013000788A1 true CL2013000788A1 (es) 2013-06-28

Family

ID=44720163

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013000788A CL2013000788A1 (es) 2010-09-23 2013-03-21 Compuestos derivados de 1,2,4-oxadiazol, inhibidores de la proteina activadora de 5-lipoxigenasa (flap); composicion farmaceutica; metodo de tratamiento; y uso para el tratamiento de un trastorno mediado por leucotrienos tal como enfermedades cardiovasculares, inflamatorias, alergicas, pulmonares y fibroticas, renales y cancer.

Country Status (19)

Country Link
US (1) US8575201B2 (h)
EP (1) EP2619197B1 (h)
JP (1) JP5713511B2 (h)
KR (1) KR20130109122A (h)
CN (1) CN103261193A (h)
AU (1) AU2011305667A1 (h)
BR (1) BR112013008638A2 (h)
CA (1) CA2812449A1 (h)
CL (1) CL2013000788A1 (h)
CO (1) CO6710902A2 (h)
EA (1) EA201300389A1 (h)
EC (1) ECSP13012548A (h)
IN (1) IN2013DN02555A (h)
MX (1) MX2013003202A (h)
PE (1) PE20131398A1 (h)
PH (1) PH12013500545A1 (h)
SG (1) SG188604A1 (h)
WO (1) WO2012040139A1 (h)
ZA (1) ZA201301747B (h)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3150164B2 (ja) 1991-05-01 2001-03-26 電気化学工業株式会社 セメント混和材及びセメント組成物
US8580829B2 (en) * 2010-08-26 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена
EP2619196B1 (en) * 2010-09-23 2015-09-16 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
US9079866B2 (en) * 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
ES2596248T3 (es) 2013-11-26 2017-01-05 Citrage N-Carbamoilputrescina para mejorar la síntesis de proteínas musculares

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL353475A1 (en) 1999-08-06 2003-11-17 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
KR20060056377A (ko) * 2003-08-13 2006-05-24 카이론 코포레이션 Gsk-3 억제제 및 그것의 사용
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
EP1814877B1 (en) 2004-10-18 2009-03-11 Merck & Co., Inc. Diphenyl substituted alkanes as flap inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
JP2009533435A (ja) * 2006-04-11 2009-09-17 メルク エンド カムパニー インコーポレーテッド ジアリール置換アルカン
EP2452683A3 (en) 2006-06-26 2012-08-22 Amgen Inc. Methods for treating atherosclerosis
WO2008030369A1 (en) * 2006-09-01 2008-03-13 Merck & Co., Inc. Inhibitors of 5 -lipoxygenase activating protein ( flap)
US20100120784A1 (en) 2007-04-20 2010-05-13 Lachance Nicolas Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2008156721A1 (en) 2007-06-20 2008-12-24 Merck & Co., Inc. Diphenyl substituted alkanes
WO2009048547A1 (en) 2007-10-10 2009-04-16 Merck & Co., Inc. Diphenyl substituted cycloalkanes
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
EP2358371B1 (en) * 2008-10-31 2015-02-11 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
WO2010089686A1 (en) 2009-02-04 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
KR20130079429A (ko) 2010-05-12 2013-07-10 벤더르빌트 유니버시티 헤테로시클릭 설폰 mglur4 알로스테릭 강화제, 조성물 및 신경 기능이상을 치료하는 방법
PH12013500301A1 (en) * 2010-08-16 2013-03-25 Boehringer Ingelheim Int Oxadiazole inhibitors of leukotriene production
US8580829B2 (en) * 2010-08-26 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EP2619196B1 (en) * 2010-09-23 2015-09-16 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена

Also Published As

Publication number Publication date
MX2013003202A (es) 2013-04-24
PH12013500545A1 (en) 2013-05-06
WO2012040139A1 (en) 2012-03-29
JP2013537909A (ja) 2013-10-07
US8575201B2 (en) 2013-11-05
ECSP13012548A (es) 2013-06-28
ZA201301747B (en) 2014-08-27
CN103261193A (zh) 2013-08-21
KR20130109122A (ko) 2013-10-07
PE20131398A1 (es) 2013-12-19
IN2013DN02555A (h) 2015-08-07
AU2011305667A1 (en) 2013-03-21
BR112013008638A2 (pt) 2016-06-21
CO6710902A2 (es) 2013-07-15
EP2619197B1 (en) 2015-08-05
JP5713511B2 (ja) 2015-05-07
US20120295896A1 (en) 2012-11-22
EA201300389A1 (ru) 2013-09-30
EP2619197A1 (en) 2013-07-31
SG188604A1 (en) 2013-04-30
CA2812449A1 (en) 2012-03-29

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