CL2012001668A1 - Composicion farmaceutica que comprende bromuro de glicopirronio disuelto en un propulsor de hidrofluoroalcano y 5 a 25% de etanol, que contiene de 0,005 y 1 µg/µl de acido clorhidrico 1m; metodo de relleno de un recipiente de aerosol con la composicion farmaceutica; uso en epoc, entre otros. - Google Patents
Composicion farmaceutica que comprende bromuro de glicopirronio disuelto en un propulsor de hidrofluoroalcano y 5 a 25% de etanol, que contiene de 0,005 y 1 µg/µl de acido clorhidrico 1m; metodo de relleno de un recipiente de aerosol con la composicion farmaceutica; uso en epoc, entre otros.Info
- Publication number
- CL2012001668A1 CL2012001668A1 CL2012001668A CL2012001668A CL2012001668A1 CL 2012001668 A1 CL2012001668 A1 CL 2012001668A1 CL 2012001668 A CL2012001668 A CL 2012001668A CL 2012001668 A CL2012001668 A CL 2012001668A CL 2012001668 A1 CL2012001668 A1 CL 2012001668A1
- Authority
- CL
- Chile
- Prior art keywords
- pharmaceutical composition
- hydrochloric acid
- epoc
- ethanol
- filling
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/04—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
- B65B31/06—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied the nozzle being arranged for insertion into, and withdrawal from, the mouth of a filled container and operating in conjunction with means for sealing the container mouth
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/10—Adding propellants in solid form to aerosol containers
Abstract
Composición farmacéutica que comprende bromuro de glicopirronio disuelto en un propulsor de hidrofluoroalcano y un cosolvente, en donde la composición contiene ácido clorhídrico 1m en el intervalo de 0,005-1,0 ug/ul; kit que la comprende; y su uso para el tratamiento o la profilaxis de enfermedades respiratorias tal como epoc.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09015980 | 2009-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012001668A1 true CL2012001668A1 (es) | 2012-12-07 |
Family
ID=42046446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012001668A CL2012001668A1 (es) | 2009-12-23 | 2012-06-19 | Composicion farmaceutica que comprende bromuro de glicopirronio disuelto en un propulsor de hidrofluoroalcano y 5 a 25% de etanol, que contiene de 0,005 y 1 µg/µl de acido clorhidrico 1m; metodo de relleno de un recipiente de aerosol con la composicion farmaceutica; uso en epoc, entre otros. |
Country Status (31)
Country | Link |
---|---|
US (4) | US20110150783A1 (es) |
EP (1) | EP2515854B1 (es) |
JP (1) | JP5800829B2 (es) |
KR (1) | KR101747474B1 (es) |
CN (1) | CN102665680B (es) |
AU (2) | AU2010334858A1 (es) |
CA (1) | CA2785317C (es) |
CL (1) | CL2012001668A1 (es) |
CO (1) | CO6551734A2 (es) |
CY (1) | CY1115109T1 (es) |
DK (1) | DK2515854T3 (es) |
EA (1) | EA021604B1 (es) |
ES (1) | ES2464520T3 (es) |
GE (1) | GEP20166479B (es) |
HK (1) | HK1174568A1 (es) |
HR (1) | HRP20140550T1 (es) |
IL (1) | IL220534A0 (es) |
MA (1) | MA33821B1 (es) |
MX (1) | MX340264B (es) |
MY (1) | MY156950A (es) |
NZ (1) | NZ600789A (es) |
PE (1) | PE20121467A1 (es) |
PL (1) | PL2515854T3 (es) |
PT (1) | PT2515854E (es) |
RS (1) | RS53355B (es) |
SG (1) | SG181870A1 (es) |
SI (1) | SI2515854T1 (es) |
TN (1) | TN2012000261A1 (es) |
UA (1) | UA106098C2 (es) |
WO (1) | WO2011076842A2 (es) |
ZA (1) | ZA201204613B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5800829B2 (ja) | 2009-12-23 | 2015-10-28 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Copd用エアロゾル製剤 |
JP5914354B2 (ja) | 2009-12-23 | 2016-05-11 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Copd用併用療法 |
WO2011076841A2 (en) * | 2009-12-23 | 2011-06-30 | Chiesi Farmaceutici S.P.A. | Combination therapy for copd |
EA033227B1 (ru) * | 2013-12-30 | 2019-09-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Находящаяся под давлением стабильная аэрозольная композиция комбинации гликопиррония бромида и формотерола в форме раствора |
MA39154A1 (fr) * | 2013-12-30 | 2017-08-31 | Chiesi Farm Spa | Composition stable pressurisée de solution pour aérosol d'une combinaison de bromure de glycopyrronium et de formotérol |
ES2866175T3 (es) | 2015-12-04 | 2021-10-19 | Mexichem Fluor Sa De Cv | Composición farmacéutica |
ES2892673T3 (es) * | 2016-09-19 | 2022-02-04 | Mexichem Fluor Sa De Cv | Composición farmacéutica que comprende glicopirrolato |
WO2020084549A1 (en) * | 2018-10-25 | 2020-04-30 | Glenmark Specialty S.A. | Nebulization composition comprising glycopyrrolate and formoterol |
KR20230052903A (ko) | 2020-07-31 | 2023-04-20 | 케모 리서치, 에스.엘. | 흡입 투여를 위한 병용 요법 |
CN112051346A (zh) * | 2020-09-24 | 2020-12-08 | 珠海瑞思普利生物制药有限公司 | 一种同时测定茚达特罗和格隆溴铵含量的hplc方法 |
JP2023546025A (ja) | 2020-10-09 | 2023-11-01 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧定量吸入器のための医薬製剤 |
WO2023227781A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
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US2956062A (en) | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
EP0673240B1 (en) | 1992-12-09 | 1999-03-24 | Boehringer Ingelheim Pharmaceuticals Inc. | Stabilized medicinal aerosol solution formulations |
CA2338680C (en) | 1998-08-04 | 2008-10-14 | Jago Research Ag | Medicinal aerosol formulations |
IT1317720B1 (it) | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
UA73986C2 (uk) * | 2000-05-22 | 2005-10-17 | К'Єзі Фармачеутічі С.П.А. | АЕРОЗОЛЬНА КОМПОЗИЦІЯ, ЩО МІСТИТЬ <font face="Symbol">b</font>2-АДРЕНЕРГІЧНИЙ АГОНІСТ ТРИВАЛОЇ ДІЇ, ДОЗУЮЧИЙ ІНГАЛЯТОР ПІД ТИСКОМ ТА СПОСІБ ЙОГО ЗАПОВНЕННЯ |
HU229798B1 (en) * | 2001-03-30 | 2014-07-28 | Jagotec Ag | Medical aerosol compositions and process for their preparation |
US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
EP1321159A1 (en) | 2001-12-21 | 2003-06-25 | CHIESI FARMACEUTICI S.p.A. | Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices |
DK3536344T3 (da) | 2002-03-01 | 2020-03-16 | Chiesi Farm Spa | Superfin formoterolformulering |
CA2510043A1 (en) | 2002-12-16 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing hfc solution formulations |
PL1718336T3 (pl) * | 2004-02-06 | 2008-11-28 | Meda Pharma Gmbh & Co Kg | Nowe połączenie środków antycholinergicznych i beta-mimetyków do leczenia chorób układu oddechowego |
GB0410399D0 (en) | 2004-05-10 | 2004-06-16 | Arakis Ltd | The treatment of respiratory disease |
GB0613161D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
EP1894568A1 (en) | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
AU2008314628B2 (en) | 2007-10-18 | 2014-03-06 | Rose U | Topical glycopyrrolate formulations |
WO2010144628A2 (en) * | 2009-06-09 | 2010-12-16 | Elevation Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease with nebulized beta 2-agonist or combined nebulized beta 2-agonist and anticholinergic administration |
ES2467928T3 (es) * | 2009-12-23 | 2014-06-13 | Chiesi Farmaceutici S.P.A. | Formulación en aerosol para EPOC |
JP5914354B2 (ja) * | 2009-12-23 | 2016-05-11 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Copd用併用療法 |
JP5800829B2 (ja) * | 2009-12-23 | 2015-10-28 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Copd用エアロゾル製剤 |
WO2011076841A2 (en) | 2009-12-23 | 2011-06-30 | Chiesi Farmaceutici S.P.A. | Combination therapy for copd |
CN106377503A (zh) * | 2010-08-03 | 2017-02-08 | 奇斯药制品公司 | 包含磷酸二酯酶抑制剂的药物制剂 |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
MA39154A1 (fr) * | 2013-12-30 | 2017-08-31 | Chiesi Farm Spa | Composition stable pressurisée de solution pour aérosol d'une combinaison de bromure de glycopyrronium et de formotérol |
EA033227B1 (ru) | 2013-12-30 | 2019-09-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Находящаяся под давлением стабильная аэрозольная композиция комбинации гликопиррония бромида и формотерола в форме раствора |
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2010
- 2010-12-22 JP JP2012545322A patent/JP5800829B2/ja active Active
- 2010-12-22 SI SI201030640T patent/SI2515854T1/sl unknown
- 2010-12-22 PL PL10799029T patent/PL2515854T3/pl unknown
- 2010-12-22 PE PE2012000851A patent/PE20121467A1/es active IP Right Grant
- 2010-12-22 EA EA201290374A patent/EA021604B1/ru active Protection Beyond IP Right Term
- 2010-12-22 MX MX2012006879A patent/MX340264B/es active IP Right Grant
- 2010-12-22 SG SG2012046173A patent/SG181870A1/en unknown
- 2010-12-22 EP EP10799029.3A patent/EP2515854B1/en active Active
- 2010-12-22 RS RS20140289A patent/RS53355B/en unknown
- 2010-12-22 NZ NZ600789A patent/NZ600789A/en unknown
- 2010-12-22 KR KR1020127014530A patent/KR101747474B1/ko active IP Right Review Request
- 2010-12-22 UA UAA201207627A patent/UA106098C2/uk unknown
- 2010-12-22 CN CN201080058049.2A patent/CN102665680B/zh active Active
- 2010-12-22 MY MYPI2012002845A patent/MY156950A/en unknown
- 2010-12-22 AU AU2010334858A patent/AU2010334858A1/en not_active Abandoned
- 2010-12-22 WO PCT/EP2010/070478 patent/WO2011076842A2/en active Application Filing
- 2010-12-22 CA CA2785317A patent/CA2785317C/en active Active
- 2010-12-22 GE GEAP201012755A patent/GEP20166479B/en unknown
- 2010-12-22 DK DK10799029.3T patent/DK2515854T3/da active
- 2010-12-22 PT PT107990293T patent/PT2515854E/pt unknown
- 2010-12-22 ES ES10799029.3T patent/ES2464520T3/es active Active
- 2010-12-23 US US12/977,181 patent/US20110150783A1/en not_active Abandoned
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2012
- 2012-05-25 TN TNP2012000261A patent/TN2012000261A1/en unknown
- 2012-06-14 MA MA34964A patent/MA33821B1/fr unknown
- 2012-06-19 CL CL2012001668A patent/CL2012001668A1/es unknown
- 2012-06-21 IL IL220534A patent/IL220534A0/en active IP Right Grant
- 2012-06-21 ZA ZA2012/04613A patent/ZA201204613B/en unknown
- 2012-06-21 CO CO12104134A patent/CO6551734A2/es not_active Application Discontinuation
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2013
- 2013-02-15 HK HK13101938.8A patent/HK1174568A1/xx unknown
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2014
- 2014-05-26 CY CY20141100374T patent/CY1115109T1/el unknown
- 2014-06-11 HR HRP20140550AT patent/HRP20140550T1/hr unknown
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2015
- 2015-07-06 US US14/791,553 patent/US10806701B2/en active Active
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2016
- 2016-09-27 AU AU2016234894A patent/AU2016234894B2/en active Active
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2020
- 2020-09-14 US US17/019,740 patent/US11590074B2/en active Active
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2023
- 2023-01-11 US US18/153,096 patent/US20230157951A1/en active Pending
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