CL2008003524A1 - Composicion farmaceutica que comprende al menos un inhibidor de proteina quinasa dependiente de arn de doble hebra (pkr), uso de la composicion para el tratamiento de una condicion seleccionada de cancer, anorexia, enfermedad inflamatoria, sepsis, falla cardiaca congestiva, artritis reumatoidea, enfermedad autoinmune, diabetes, fiebre reumatoidea, progenia. - Google Patents

Composicion farmaceutica que comprende al menos un inhibidor de proteina quinasa dependiente de arn de doble hebra (pkr), uso de la composicion para el tratamiento de una condicion seleccionada de cancer, anorexia, enfermedad inflamatoria, sepsis, falla cardiaca congestiva, artritis reumatoidea, enfermedad autoinmune, diabetes, fiebre reumatoidea, progenia.

Info

Publication number
CL2008003524A1
CL2008003524A1 CL2008003524A CL2008003524A CL2008003524A1 CL 2008003524 A1 CL2008003524 A1 CL 2008003524A1 CL 2008003524 A CL2008003524 A CL 2008003524A CL 2008003524 A CL2008003524 A CL 2008003524A CL 2008003524 A1 CL2008003524 A1 CL 2008003524A1
Authority
CL
Chile
Prior art keywords
composition
rheumatoid
disease
pkr
anorexia
Prior art date
Application number
CL2008003524A
Other languages
English (en)
Inventor
Michael John Tisdale
Helen Laura Eley
Steve Thomas Russell
Kevin Burke Miller
Original Assignee
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40099551&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008003524(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nestec Sa filed Critical Nestec Sa
Publication of CL2008003524A1 publication Critical patent/CL2008003524A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Polymers & Plastics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • AIDS & HIV (AREA)

Abstract

Composición farmacéutica que comprende al menos un inhibidor de proteína quinasa dependiente de ARN de doble hebra (PKR), uso de la composición para el tratamiento de una condición seleccionada de cáncer, anorexia, enfermedad inflamatoria, sepsis, falla cardiaca congestiva, artritis reumatoidea, enfermedad autoinmune, diabetes, fiebre reumatoidea, progenia.
CL2008003524A 2007-11-26 2008-11-26 Composicion farmaceutica que comprende al menos un inhibidor de proteina quinasa dependiente de arn de doble hebra (pkr), uso de la composicion para el tratamiento de una condicion seleccionada de cancer, anorexia, enfermedad inflamatoria, sepsis, falla cardiaca congestiva, artritis reumatoidea, enfermedad autoinmune, diabetes, fiebre reumatoidea, progenia. CL2008003524A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99013407P 2007-11-26 2007-11-26
US3737108P 2008-03-18 2008-03-18

Publications (1)

Publication Number Publication Date
CL2008003524A1 true CL2008003524A1 (es) 2010-01-22

Family

ID=40099551

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003524A CL2008003524A1 (es) 2007-11-26 2008-11-26 Composicion farmaceutica que comprende al menos un inhibidor de proteina quinasa dependiente de arn de doble hebra (pkr), uso de la composicion para el tratamiento de una condicion seleccionada de cancer, anorexia, enfermedad inflamatoria, sepsis, falla cardiaca congestiva, artritis reumatoidea, enfermedad autoinmune, diabetes, fiebre reumatoidea, progenia.

Country Status (14)

Country Link
US (1) US20110077198A1 (es)
EP (1) EP2222297A1 (es)
JP (1) JP2011504879A (es)
CN (1) CN101868235A (es)
AR (1) AR069479A1 (es)
AU (1) AU2008329988A1 (es)
BR (1) BRPI0819759A2 (es)
CA (1) CA2706656A1 (es)
CL (1) CL2008003524A1 (es)
MX (1) MX2010005768A (es)
RU (1) RU2010126171A (es)
TW (1) TW200924744A (es)
WO (1) WO2009070378A1 (es)
ZA (1) ZA201004528B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010073104A2 (en) * 2008-12-23 2010-07-01 Carmel - Haifa University Economic Corp Ltd. Improving cognitive function
EP2464246A2 (en) * 2009-08-13 2012-06-20 Nestec S.A. Nutritional compositions including exogenous nucleotides
JP2013505720A (ja) * 2009-09-25 2013-02-21 ネステク ソシエテ アノニム テアニン及び外因性ヌクレオチドを含む栄養組成物
AU2010310515B2 (en) * 2009-10-22 2016-01-07 University Of Southern California Methods and nutritional formulations to increase the efficacy and reduce the side effects of cancer treatment
FR2970414B1 (fr) * 2011-01-14 2013-03-22 Univ Paris Descartes Action preventive de la citrulline sur le developpement spontane des tumeurs
TW201330845A (zh) * 2011-10-18 2013-08-01 Ajinomoto Kk 胰臟癌及／或膽道癌治療劑
CN104039353A (zh) * 2011-11-29 2014-09-10 贝勒医学院 增强认知的方法
CN104023715B (zh) * 2011-12-02 2016-10-26 Ea制药株式会社 激酶抑制剂的副作用降低剂
ES2822178T3 (es) 2012-10-22 2021-04-29 Univ Southern California Formulaciones dietéticas que promueven la regeneración de tejidos/órganos
KR101668074B1 (ko) * 2015-02-12 2016-10-21 전북대학교산학협력단 Ｐｋｒ 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
CN107158388B (zh) * 2017-07-11 2021-03-23 上海市第一人民医院 MIIP pS303阻断剂在制备抗肿瘤药物中的应用
JP7266581B2 (ja) 2017-08-14 2023-04-28 アクセラ・ヘルス・インコーポレイテッド 肝疾患の治療のためのアミノ酸組成物
US10596136B2 (en) 2018-06-20 2020-03-24 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
WO2023208028A1 (zh) * 2022-04-29 2023-11-02 中国科学院分子细胞科学卓越创新中心 用于治疗牛皮癣或阿尔兹海默症的具有16bp-26bp双链茎环结构的环形RNA

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06501024A (ja) * 1991-03-29 1994-01-27 アメリカ合衆国 皮膚腫瘍形成を予防し、存在する腫瘍の後退の原因になるための医薬組成物と方法
AU3982497A (en) * 1996-07-30 1998-02-20 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Double-stranded rna dependent protein kinase derived peptides to promote proliferation of cells and tissues in controlled manner
AU6336398A (en) * 1997-02-24 1998-09-09 Johns Hopkins University, The Immunomodulatory polypeptides derived from the invariant chain of mhc class ii
US6864061B2 (en) * 2000-09-14 2005-03-08 Genetrol Biotherapeutics, Inc. Method for screening compounds for anti-inflammatory activity
EP1911449A1 (en) * 2005-07-29 2008-04-16 Ltd. Torii Pharmaceutical Co. Anti-tumor agent comprising 6'-amidino-2'-naphthyl4- guanidinobenzoate or salt thereof
DK1957061T3 (da) * 2005-11-30 2011-07-25 Novartis Pharma Gmbh Kombination omfattende mindst én aminosyre og en PKR-inhibitor til anvendelse i behandlingen af muskelsvind
AU2008260572A1 (en) * 2007-05-29 2008-12-11 Yale University IL- 18 and protein kinase R inhibition for the treatment of COPD

Also Published As

Publication number Publication date
WO2009070378A1 (en) 2009-06-04
ZA201004528B (en) 2011-11-30
JP2011504879A (ja) 2011-02-17
TW200924744A (en) 2009-06-16
AU2008329988A1 (en) 2009-06-04
AR069479A1 (es) 2010-01-27
BRPI0819759A2 (pt) 2015-05-05
MX2010005768A (es) 2010-06-11
US20110077198A1 (en) 2011-03-31
CA2706656A1 (en) 2009-06-04
RU2010126171A (ru) 2012-01-10
EP2222297A1 (en) 2010-09-01
CN101868235A (zh) 2010-10-20

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