CL2007001737A1 - Compuestos derivados de cianopiridinas; inhibidores de proteina quinasa;composicion farmaceutica;y uso para el tratamiento o inhibicion de un trastorno mediado por una proteina quinasa,tal como enfermedad autoinmune e inflamatoria. - Google Patents
Compuestos derivados de cianopiridinas; inhibidores de proteina quinasa;composicion farmaceutica;y uso para el tratamiento o inhibicion de un trastorno mediado por una proteina quinasa,tal como enfermedad autoinmune e inflamatoria.Info
- Publication number
- CL2007001737A1 CL2007001737A1 CL2007001737A CL2007001737A CL2007001737A1 CL 2007001737 A1 CL2007001737 A1 CL 2007001737A1 CL 2007001737 A CL2007001737 A CL 2007001737A CL 2007001737 A CL2007001737 A CL 2007001737A CL 2007001737 A1 CL2007001737 A1 CL 2007001737A1
- Authority
- CL
- Chile
- Prior art keywords
- protein kinase
- cyanopyridines
- autoimmune
- inhibition
- treatment
- Prior art date
Links
- FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical class N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 102000001253 Protein Kinase Human genes 0.000 title abstract 2
- 230000001363 autoimmune Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108060006633 protein kinase Proteins 0.000 title abstract 2
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81306006P | 2006-06-13 | 2006-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001737A1 true CL2007001737A1 (es) | 2008-01-25 |
Family
ID=38738795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2007001737A CL2007001737A1 (es) | 2006-06-13 | 2007-06-13 | Compuestos derivados de cianopiridinas; inhibidores de proteina quinasa;composicion farmaceutica;y uso para el tratamiento o inhibicion de un trastorno mediado por una proteina quinasa,tal como enfermedad autoinmune e inflamatoria. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2029543B1 (enExample) |
| JP (1) | JP2009539998A (enExample) |
| KR (1) | KR20090018612A (enExample) |
| CN (1) | CN101466678B (enExample) |
| AR (1) | AR061368A1 (enExample) |
| AU (1) | AU2007258237A1 (enExample) |
| BR (1) | BRPI0712737A2 (enExample) |
| CA (1) | CA2654515C (enExample) |
| CL (1) | CL2007001737A1 (enExample) |
| ES (1) | ES2558706T3 (enExample) |
| IL (1) | IL194625A0 (enExample) |
| MX (1) | MX2008015802A (enExample) |
| NO (1) | NO20084739L (enExample) |
| PE (1) | PE20080336A1 (enExample) |
| RU (1) | RU2008139079A (enExample) |
| TW (1) | TW200815407A (enExample) |
| WO (1) | WO2007146376A2 (enExample) |
| ZA (1) | ZA200810573B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007001738A1 (es) * | 2006-06-13 | 2008-01-18 | Wyeth Corp | Compuestos derivados de cianopiridinas; composicion farmaceutica; y uso para el tratamiento o inhibicion de un trastorno mediado por una proteina quinasa, tal como enfermedad autoinmune e inflamatoria. |
| WO2010026122A1 (en) | 2008-09-02 | 2010-03-11 | Novartis Ag | Heterocyclic pim-kinase inhibitors |
| CN113735785B (zh) * | 2020-05-28 | 2023-10-13 | 南京桦冠生物技术有限公司 | 3,6-二氯吡嗪-2-甲腈的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ303899B6 (cs) * | 1998-09-29 | 2013-06-19 | Wyeth Holdings Corporation | Substituovaný 3-kyanochinolin, zpusob jeho prípravy a farmaceutická kompozice s jeho obsahem |
| US6821988B2 (en) * | 2001-11-27 | 2004-11-23 | Wyeth Holdings Corporation | 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases |
| AU2003296414A1 (en) * | 2002-12-12 | 2004-07-09 | Pharmacia Corporation | Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors |
| AU2006247520A1 (en) * | 2005-05-18 | 2006-11-23 | Wyeth | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same |
-
2007
- 2007-06-13 MX MX2008015802A patent/MX2008015802A/es active IP Right Grant
- 2007-06-13 ES ES07796104T patent/ES2558706T3/es active Active
- 2007-06-13 BR BRPI0712737-5A patent/BRPI0712737A2/pt not_active IP Right Cessation
- 2007-06-13 WO PCT/US2007/013954 patent/WO2007146376A2/en not_active Ceased
- 2007-06-13 AR ARP070102593A patent/AR061368A1/es unknown
- 2007-06-13 JP JP2009515487A patent/JP2009539998A/ja not_active Withdrawn
- 2007-06-13 TW TW096121311A patent/TW200815407A/zh unknown
- 2007-06-13 CL CL2007001737A patent/CL2007001737A1/es unknown
- 2007-06-13 EP EP07796104.3A patent/EP2029543B1/en not_active Not-in-force
- 2007-06-13 CN CN2007800216875A patent/CN101466678B/zh not_active Expired - Fee Related
- 2007-06-13 RU RU2008139079/04A patent/RU2008139079A/ru not_active Application Discontinuation
- 2007-06-13 AU AU2007258237A patent/AU2007258237A1/en not_active Abandoned
- 2007-06-13 KR KR1020087028580A patent/KR20090018612A/ko not_active Withdrawn
- 2007-06-13 CA CA2654515A patent/CA2654515C/en not_active Expired - Fee Related
- 2007-06-13 PE PE2007000746A patent/PE20080336A1/es not_active Application Discontinuation
-
2008
- 2008-10-07 IL IL194625A patent/IL194625A0/en unknown
- 2008-11-10 NO NO20084739A patent/NO20084739L/no not_active Application Discontinuation
- 2008-12-12 ZA ZA200810573A patent/ZA200810573B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007258237A1 (en) | 2007-12-21 |
| CA2654515A1 (en) | 2007-12-21 |
| CA2654515C (en) | 2014-04-01 |
| ES2558706T3 (es) | 2016-02-08 |
| CN101466678B (zh) | 2012-12-26 |
| TW200815407A (en) | 2008-04-01 |
| EP2029543B1 (en) | 2015-11-18 |
| MX2008015802A (es) | 2009-01-09 |
| NO20084739L (no) | 2009-01-06 |
| EP2029543A2 (en) | 2009-03-04 |
| WO2007146376A2 (en) | 2007-12-21 |
| RU2008139079A (ru) | 2010-07-20 |
| WO2007146376A3 (en) | 2008-03-13 |
| KR20090018612A (ko) | 2009-02-20 |
| CN101466678A (zh) | 2009-06-24 |
| JP2009539998A (ja) | 2009-11-19 |
| ZA200810573B (en) | 2009-09-30 |
| AR061368A1 (es) | 2008-08-20 |
| IL194625A0 (en) | 2009-08-03 |
| PE20080336A1 (es) | 2008-06-03 |
| BRPI0712737A2 (pt) | 2012-05-08 |
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