CH90888A - Process for the preparation of an alkaline earth salt of glutamic acid. - Google Patents

Process for the preparation of an alkaline earth salt of glutamic acid.

Info

Publication number
CH90888A
CH90888A CH90888DA CH90888A CH 90888 A CH90888 A CH 90888A CH 90888D A CH90888D A CH 90888DA CH 90888 A CH90888 A CH 90888A
Authority
CH
Switzerland
Prior art keywords
glutamic acid
preparation
alkaline earth
calcium
earth salt
Prior art date
Application number
Other languages
German (de)
Inventor
Farbenfabriken Vorm Friedr Co
Original Assignee
Farbenfab Vorm Bayer F & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farbenfab Vorm Bayer F & Co filed Critical Farbenfab Vorm Bayer F & Co
Publication of CH90888A publication Critical patent/CH90888A/en

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Description

  

  Verfahren zur Darstellung eines     Erdalkallsalzes    der     Gltitaininsäure.            Es#wurde    gefunden,     dass    das     Caleiumsa17     der     Glutaminsäure    mit     Caleiumbromid    eine  gut     kristallisierende    Verbindung liefert, die  sich durch leichte     Wasserlöslichkeit,    ange  nehmen Geschmack, sehr hohen Gehalt an  therapeutisch wertvoller Substanz und voll  kommene Luftbeständigkeit auszeichnet.

    Man verfährt zu ihrer Darstellung zweck  mässig in der Weise,     dass    man die Lösung  des     glutaminsauren        Caleiums    mit     Calcium-          bromid    versetzt oder ein Gemisch der     Glu-          taminsäure    und der     Bromwasserstoffsäure     mit     Calciumkarbonat        absättigt.     



  <I>Beispiel:</I>  Eine Lösung von 147     Gew        ichtsteilen          Glutaminsäure    in i000 Gewichtsteilen     hei-          Bem    Wasser wird mit     55    Gewichtsteilen       Calciumkarbonat        abgesättigt,    nach dem     Ab-          fütilieren    vom ungelösten     Calciumkarbonat     mit einer wässerigen Lösung von<B>105</B> Ge  wichtsteilen     Calciumbromid    versetzt und  eingedampft.

   Die Verbindung scheidet sich  dabei in derben Kristallkrusten ab, die    nach möglichst vollständigem- Eindampfen  scharf abgesaugt und durch Wasche n mit  <B>50!</B>     %igem    Alkohol von etwa     überschümi-          gem        Bromealcium    befreit werden.  



  Die bei     90-100        Q    getrocknete Substanz  bildet eine weisse, verwitterte Salzmasse, die  vollständig<B>.</B> luftbeständig ist. Sie enthält  auf     i        Mol.        Glutaminsäure   <B>1</B> Atom Brom,       J-    Atom     Caleium    und<B>1</B>     Mol.        Kristallwasµer.     Ihre Lösungen zeigen neutrale Reaktion und  angenehmen Geschmack.  



  Man kann auch so verfahren,     dass    man  das Gemisch von     Glutaminsaure    und     Cal-          eiumbromid    mit     Caleiumkarbonat        absättigt     und eindampft.



  Process for the preparation of an alkaline earth salt of gltitainic acid. It has been found that the caleiumsa17 of glutamic acid with caleium bromide provides a compound that crystallizes well, which is characterized by easy water solubility, pleasant taste, very high content of therapeutically valuable substance and perfect air resistance.

    It is expedient to proceed in such a way that the solution of glutamic acid is mixed with calcium bromide or a mixture of glutamic acid and hydrobromic acid is saturated with calcium carbonate.



  <I> Example: </I> A solution of 147 parts by weight of glutamic acid in 1000 parts by weight of hot water is saturated with 55 parts by weight of calcium carbonate, after the undissolved calcium carbonate has been filtered off with an aqueous solution of <B> 105 </ B > Parts by weight of calcium bromide added and evaporated.

   The compound is deposited in coarse crystal crusts which, after evaporation is as complete as possible, are sucked out sharply and freed from excess bromine calcium by washing with 50% alcohol.



  The substance dried at 90-100 Q forms a white, weathered salt mass that is completely <B>. </B> air-resistant. It contains <B> 1 </B> atom of bromine, J-atom caleium and <B> 1 </B> mol. Of crystalline water per 1 mol of glutamic acid. Your solutions show a neutral reaction and a pleasant taste.



  One can also proceed in such a way that the mixture of glutamic acid and calcium bromide is saturated with calcium carbonate and evaporated.

Claims (1)

PATENTANAPRUCH: Verfahren zur Darstellung einer Ver bindung der GluiaminsäLtre, mit Caleium-. brömid, dadurch gekennzeichnet, dass man das Calciumsalz der Glutaminsäure <B>*</B> mit Calciumbromid behandelt.<B>- I .</B> Die bei 90-100-' getrocknete"5Libstanz bildet eine weisse, verwitterte Salzmasse, die vollständig luftbeständig und leicht in Wasser. PATENTANAPRUCH: Process for the preparation of a connection of the GluiaminsäLtre, with Caleium-. brömid, characterized in that the calcium salt of glutamic acid <B> * </B> is treated with calcium bromide. <B> - I. </B> The vitality that is dried at 90-100- 'forms a white, weathered mass of salt, which are completely air-resistant and light in water. löslich ist.<B>-</B> Sie enthält auf<B>1</B> 'Mol. Glutaminsäure. i Atom Brom und i Atom Calcium neben<B>1</B> Mol. Kristallwasser. Ihre LösLingen zeigen neu trale Reaktion und an- genehnien Geschmack. is soluble. <B> - </B> It contains <B> 1 </B> 'moles. Glutamic acid. i atom of bromine and i atom of calcium in addition to <B> 1 </B> mol. Your lozenges show a neutral reaction and a pleasant taste.
CH90888D 1919-08-07 1920-07-19 Process for the preparation of an alkaline earth salt of glutamic acid. CH90888A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE90888X 1919-08-07
CH90414T 1920-07-19

Publications (1)

Publication Number Publication Date
CH90888A true CH90888A (en) 1921-10-01

Family

ID=25704167

Family Applications (1)

Application Number Title Priority Date Filing Date
CH90888D CH90888A (en) 1919-08-07 1920-07-19 Process for the preparation of an alkaline earth salt of glutamic acid.

Country Status (1)

Country Link
CH (1) CH90888A (en)

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