CH718673A1 - Oral care compositions. - Google Patents

Abstract

The present invention relates to the field of care for the oral sphere, and more particularly, to a composition comprising soy and avocado unsaponifiables. The invention also relates to its use for cleaning the oral sphere and a process for manufacturing such a composition.

Description

FIELD OF THE INVENTION

The present invention relates to the field of care of the oral sphere, and more particularly to a composition comprising soy and avocado unsaponifiables. The invention also relates to a process for manufacturing such a composition and its use for cleaning the oral sphere.

STATE OF THE ART

[0002] Many oral and systemic diseases have as their cause or origin an imbalance of oral homeostasis. The oral cavity is the first part of the digestive system. It is she who receives the food, allows it to be transformed into a food bolus by the action of chewing and saliva. These two actions, essential for good digestion, require a healthy mouth: healthy teeth well maintained in the bone cavity and saliva of good composition.

[0003] In the event of an imbalance in the oral homeostasis due in particular to a diet that is too rich in sugars, poor oral hygiene or an immune imbalance, the oral microorganisms develop abnormally, particularly at the level of dental plaque. They cause periodontal diseases, dental caries, or conditions affecting in particular cardiac function, or cognitive function such as, for example, in the case of Alzheimer's disease.

[0004] Dental caries is an infectious disease of the tooth which is manifested by a lesion of the enamel, of the cementum, of the dentin or even of the pulp, depending on the stage of development. The appearance of dental caries depends on many factors including the nature of the oral bacterial flora, the diet and frequency of absorption of nutrients and other substances (sugars, alcohol, tobacco, drugs), the state of health of the salivary and immune system of the host, genetics, stress, and vitamin D deficiency. Caries formation begins with an imbalance of the biofilm allowing certain bacteria naturally present in the balanced and healthy microbiota to reproduce more quickly and reach a critical pathogenic threshold. The attack of the enamel by the secretions of the bacteria forms a hole which first appears as a whitish spot then evolves towards the dentin and can blacken. The cavity progresses and gradually enlarges towards the pulp which ends up being colonized by germs and necrosing. It can then invade the underlying tissues or even pass into the general circulation. The infection can develop over several months or even years.

[0005] Periodontal diseases include attacks affecting the supporting tissues of the teeth, namely the gums, the alveolar bone, the alveolodental ligament and the cementum. Depending on the tissues affected, we speak of gingivitis when the inflammation concerns the gums or of periodontitis when the damage concerns all the tissues. The bone loss that results from these diseases is called alveolysis. Periodontal diseases are due to the development of dental plaque, particularly in the area between the gum and the tooth. They evolve towards the loosening of the teeth.

[0006] Prevention, by avoiding the formation of dental plaque and by reducing acid attacks, remains the safest and most effective means of combating dental caries and periodontal diseases. The prevention of oral diseases such as cavities and periodontal diseases and their possible consequences on systemic health requires good oral hygiene. This generally involves the mechanical and systematic brushing of the teeth, ideally after any intake of food, drink or other substances such as tobacco or medication likely to disturb the physiological conditions of the mouth. However, in many contexts this ideal is not achievable. Indeed, generally brushing teeth requires a water point and accessories such as toothbrush and toothpaste.

[0007] In the field of oral care, certain compositions are available in the form of effervescent tablets (EP2249776A2, EP1054658A1, US6811793B2). However, many compositions require rinsing of the oral sphere with water, not allowing their use in all circumstances.

[0008] Thus, in the field of oral care, there is a real need for oral care compositions in a galenic form that is easy to take in all circumstances and can be consumed, the properties of its components of which make it possible to fight against effective way against the many attacks of the oral sphere.

SUMMARY OF THE INVENTION

[0009] The subject of the invention is an oral care composition comprising (i) 5 to 20% by mass of avocado and soy unsaponifiables, (ii) 3 to 10% by mass of plant extract , (iii) 6 to 12% by mass arginine, (iv) 20 to 40% by mass calcium phosphate, (v) 5 to 30% by mass sodium bicarbonate, (vi) 5 to 30% by mass of citric acid, and (vii) 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition.

Another object relates to the use of an oral care composition according to the present invention in the treatment and/or prevention of oral diseases chosen from the group comprising periodontal diseases, dental caries and dental caries. halitosis.

Another object also relates to the use of an oral care composition according to the invention for reducing acid erosion of enamel, reducing biofilm and plaque generated by bacteria, reducing gingivitis , prevent tooth decay, prevent the formation of canker sores, and/or reduce dentin hypersensitivity.

Another object of the present invention relates, moreover, to a process for the manufacture of an oral care composition comprising (i) the mixture of 5 to 20% by mass of unsaponifiables of avocado and soybeans, 3-10% by mass plant extract, 6-12% by mass arginine, 20-40% by mass calcium phosphate, 5-30% by mass baking soda, 5-30% by mass of citric acid, 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition, and (ii) the formation of a tablet by compression.

BRIEF DESCRIPTION OF FIGURES

Fig.1: In a subject with dental plaque of 0 days, Figure 1 shows the pH measured continuously for a period of 110 minutes after absorption of paraffin (PC), after absorption of the composition according to this invention, by rinsing with water (W), after absorption of a 10% sucrose solution (sucrose). Fig.2: In a subject with dental plaque for 5 days, FIG. 2 shows the pH measured continuously for a period of 110 minutes after absorption of paraffin (PC), after absorption of the composition according to the present invention, in rinsing with water (W), after absorption of a 10% sucrose solution (sucrose).

DETAILED DESCRIPTION OF THE INVENTION

The object of the invention described below is to provide an oral care composition comprising (i) 5 to 20% by mass of avocado and soy unsaponifiables, (ii) 3 to 10% by mass of plant extract, (iii) 6 to 12% by mass of arginine, (iv) 20 to 40% by mass of calcium phosphate, (v) 5 to 30% by mass of baking soda, (vi ) 5 to 30% by mass of citric acid, and (vii) 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition.

[0015] The avocado and soy unsaponifiables are substances present in the residual fraction that are insoluble in water but soluble in organic solvents after saponification, such as phytosterols. The phytosterols are in particular beta-sitosterol, campesterol and/or stigmasterol. Advantageously, the avocado and soy unsaponifiables participate in the stimulation and repair of injured tissues such as the gums. In addition, they have a lubricating effect compensating for the drying effect of the sodium bicarbonate/citric acid components.

According to the present invention, the oral care composition comprises 5 to 20%, 5 to 15%, 5 to 10%, or 5 to 8% by weight of avocado and soy unsaponifiables, relative to the total weight of the composition. Preferably, the composition comprises 6% by weight of avocado and soy unsaponifiables, relative to the total weight of the composition.

[0017] It is possible to use other substances allowing the repair of damaged tissues in a mixture with the unsaponifiables of avocado and soya, or alone such as vitamin C, gotu kola, horsetail, acerola, rosehip, sea buckthorn, garlic mustard, hawthorn, watercress, rosehip. Thus the composition according to the invention comprises at least 5 to 20% by mass of a component chosen from avocado and soy unsaponifiables, vitamin C, gotu kola, horsetail, acerola, rose hip, sea buckthorn, garlic mustard, hawthorn, watercress, or rosehip, or a mixture thereof.

[0018] The oral care composition also comprises 3 to 10%, 3 to 8%, or 3 to 6% by weight of a plant extract, based on the total weight of the composition. Preferably, the composition comprises 4% by mass of a plant extract, relative to the total weight of the composition. In addition, the plant extract is chosen for its properties promoting the remineralization of enamel or the reduction of inflammation of the gums, its abrasive effect, or its anti-adhesion effect of biofilm and plaque generated by bacteria . The plant extract is chosen from the group comprising acerola, yarrow, sweet flag, agrimony, lady's mantle, garlic mustard, aloe vera, angelica, sea buckthorn, mugwort, artichoke, hawthorn, avocado, avens, white broth, birch, bearberry, peanut, calendula, cannabis, cranberry, cinnamon, cardamom, caraway, blackcurrant, chestnut, sessile oak, chicory, watercress, turmeric, rosehip, rose hip, cypress, echinacea, rosehip, eucalyptus, boneset, fennel, fumitory, juniper, yellow gentian, cloves, gotu kola, marshmallow, witch hazel, hops, lavender, lychee, magnolia, horse chestnut, chamomile, mallow, walnut, nettle, small centaury, maritime pine, Scots pine, plantain, cinquefoil, horsetail, cinchona, liquorice, queen meadowsweet, rhubarb, rosemary, saffron, sage, wild thyme, siwak, elderberry, tea, green tea, thyme, coltsfoot, goldenrod, or red vine, or a mixture thereof. Substances can be envisaged in combination with the plant extract, or alone, such as alginates, betaines, carnosine, carrageenans, probiotics, or propolis.

[0019] Preferably, the plant extract is chosen from an extract of green tea, siwak, cranberry, cannabis, liquorice or a mixture thereof.

[0020] According to a particular embodiment of the present invention, the oral care composition may also comprise a second plant extract containing active principles reducing certain oral bacterial populations, modifying their metabolisms or their ecosystem. The second plant extract is selected from the group comprising eucalyptus, licorice, sage, yarrow, echinacea, calendula, clove, lavender, potentilla, rosemary, thyme, garlic mustard, and juniper. Preferably, the oral care composition further comprises eucalyptus extract. The composition may also comprise from 1 to 7% by weight of this second plant extract such as an extract of eucalyptus, relative to the total weight of the composition. Preferably, 2% by mass of this second plant extract, relative to the total weight of the composition. Advantageously, these extracts make it possible to neutralize unpleasant odors, considered to be bothersome and responsible for halitosis.

The oral care composition according to the invention further comprises substances chosen from zinc salts, such as zinc citrate. They also make it possible to neutralize the unpleasant odors of halitosis, in particular linked to the release of sulfur molecules. According to the invention, the composition comprises 0.1 to 1%, 0.1 to 0.5% by weight of zinc citrate, relative to the total weight of the composition. Preferably, 0.25% by weight of zinc citrate, relative to the total weight of the composition

[0022] Furthermore, during food intake, acidic foods and beverages rich in fast sugars induce a decrease in the pH in the mouth. In order to prevent dental erosion, it is desirable for the pH to be between 6 and 8. Slightly basic substances make it possible to restore the physiological conditions after food intake, such as sodium bicarbonate or arginine.

[0023] Thus, the oral care composition comprises 6 to 12%, 6 to 10% by mass of arginine, relative to the total weight of the composition. Preferably, the composition comprises 8% by mass of arginine, relative to the total weight of the composition.

[0024] The oral care composition also comprises 5 to 30%, 5 to 20%, 5 to 15%, 7 to 10% by weight of baking soda, based on the total weight of the composition. Preferably, the composition comprises 9% by weight of sodium bicarbonate, relative to the total weight of the composition.

[0025] During the use of a composition according to the present invention, the continuous measurement of the pH made it possible to show that the pH remains between 6 and 8 (cf. Example 4). Advantageously, the use of the present composition respects the physiological conditions of the pH of the oral sphere. Thus, the invention relates to an oral care composition in which the pH after administration of said composition is between 6 and 8.

[0026] In addition, mineral substances such as calcium phosphate, calcium carbonate, sodium carbonate, lithothamnium or silica are used as a cleaning agent due to their abrasive effect. Preferably, the use of calcium salts such as calcium phosphate as a polishing agent or cleaning agent promotes the remineralization of dental enamel. According to the invention, the oral care composition comprises 20 to 40%, 30 to 40%, 32 to 37% by mass of calcium phosphate, relative to the total weight of the composition. Preferably, the composition comprises 34.8% by mass of calcium phosphate, relative to the total weight of the composition.

[0027] According to the invention, the oral care composition can be in different forms, for example dosage forms that do not require the use of water and that are easy to use by anyone, including the elderly or elderly. very young. The composition according to the invention may be in the form of a chewable or chewable tablet, lozenge, powder, granules, gum, paste, gel or cream. Preferably, the composition is in the form of a chewable or chewable tablet (Example 3).

Various other substances can be incorporated into the composition according to the invention such as sweeteners, humectants, surfactants, flavorings or lubricants.

According to a particular embodiment of the present invention, the oral care composition further comprises at least one sweetener chosen from polyols such as sorbitol, xylitol, plant extracts such as stevia, rebaudioside A, miracle berry, miraculin, licorice, gycyrrhizin, proteins such as brazzlin, curculin, mabinlin, monellin, pentadin, and/or other sweeteners such as acesulfame, alitame, aspartame, cyclamate, neotame, saccharin, and/or sucralose. Preferably, the sweetener is chosen from sorbitol, stevia, and/or miraculin.

In another particular embodiment of the present invention, the oral care composition further comprises at least one humectant chosen from polyols such as glycerin, propylene glycol, polyethylene glycols, amino acids such as proline, plants rich in mucilages such as Aloe vera, and derivatives of betaine.

Another particular embodiment also relates to an oral care composition further comprising at least one surfactant chosen from lecithin, cocamidopropyl betaine, and polyoxyethylenated oleolinoleic glycerides.

According to another particular embodiment, the oral care composition further comprises at least one lubricant such as magnesium stearate.

[0033] In another particular mode of the invention, the oral care composition also comprises at least one flavoring or a natural flavoring chosen from mint, citrus fruits or red fruits.

In a particular embodiment of the present invention, without being limiting, the oral care composition comprises (i) 6% by mass of avocado and soy unsaponifiables, (ii) 4% by mass plant extract, (iii) 8% by mass of arginine, (iv) 34.8% by mass of calcium phosphate, (v) 9% by mass of sodium bicarbonate, (vi) 7.5% by mass of citric acid, (vii) 0.25% by mass zinc citrate, (viii) 28% by mass sorbitol, (ix) 0.15% by mass stevia, (x) 1.8% by mass flavors, and (xi) 0.5% by mass of magnesium stearate, relative to the total weight of the composition.

Preferably, the plant extract is chosen from an extract of green tea, siwak, cranberry, cannabis, liquorice or a mixture thereof (Example 1).

The invention also relates to a method for manufacturing an oral care composition, the method comprising the preparation of a mixture comprising 5 to 20% by mass of avocado and soy unsaponifiables, 3 to 10% by mass plant extract, 6-12% by mass arginine, 20-40% by mass calcium phosphate, 5-30% by mass baking soda, 5-30% by mass citric acid, 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition.

[0037] Preferably, the method of manufacture relates to an oral care composition in the form of a chewable tablet, the method comprising (i) the preparation of a composition comprising the mixture of 5 to 20% by mass of 'unsaponifiables of avocado and soya, 3 to 10% by mass of plant extract, 6 to 12% by mass of arginine, 20 to 40% by mass of calcium phosphate, 5 to 30% by mass of bicarbonate sodium hydroxide, 5 to 30% by mass of citric acid, 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition, and (ii) the formation of a tablet by compression.

[0038] The invention also relates to an oral care composition, for its use in the treatment and/or prevention of oral diseases chosen from the group comprising periodontal diseases such as gingivitis, periodontitis, or canker sores. , dental caries and halitosis.

Furthermore, an oral care composition according to the invention can be used as a toothpaste to reduce acid erosion of enamel, reduce biofilm and plaque generated by bacteria, reduce gingivitis, reduce halitosis, prevent tooth decay, prevent the formation of canker sores, and/or reduce dentin hypersensitivity.

[0040] In the preferred practical application of the present invention, the invention also relates to a method for cleaning the oral sphere comprising (i) the oral intake of an oral care composition, under chewable tablet form, (ii) dissolving the tablet in the presence of saliva, and (iii) contacting and cleaning the oral sphere with the dissolved tablet using the tongue.

Advantageously, the method according to the invention does not require the use of a toothbrush or water. Indeed, the use of water is not necessary to activate the foam formed only in the presence of saliva. The saliva secretion reflex is triggered by the presence of acidic compounds present at 5-30%, 5-10% by mass relative to the total weight of the composition, such as citric acid, ascorbic acid or l malic acid. Preferably, the composition comprises 7.5% by weight of citric acid.

According to the invention, the amounts of sodium bicarbonate and citric acid are adapted to control the effervescence, not to cause drying of the mouth and to avoid an unpleasant feeling of gas.

[0043] In addition to its cleaning action for the teeth, the composition according to the present invention has anti-inflammatory, bacteriostatic and antibacterial properties which act on the gums. People using the composition in different galenic forms such as chewable or chewable tablet, tablet, powder, granules, gum, paste, gel, or cream have gums that are strengthened by the reduction of dental plaque and inflammation mucous membranes.

In addition, the formulation of the composition according to the invention has been designed so as to be compatible with food so as to be able to swallow it after having cleaned the teeth. Thus, the invention relates to an oral care composition wherein the composition is consumable and/or digestible after absorption.

[0045] Advantageously, the composition according to the invention is a complete care because it allows use both as a toothpaste, as a mouthwash and as a food supplement when it is swallowed at the end of cleaning.

EXAMPLES

1. Oral care compositions

Oral care compositions in accordance with the invention have been prepared comprising between 5-20% of unsaponifiable soy and avocado and extracts from plants such as green tea, siwak (root of Salvadora persica shrub), cranberry, or licorice.

Table 1: composition 1 based on green tea extract

[0047] Soy and avocado unsaponifiables 6.00% 5-20% Green tea extract 4.00% 3-10% Calcium phosphate 34.80% 20-40% Baking soda 9.00% 5-30% Citric acid 7.50% 5-30 % Arginine 8.00% 6-12% Zinc Citrate 0.25% 0.1-1% Sorbitol 28.00% QSP Stevia 0.15% QSP Aroma 1.80% QSP Magnesium Stearate 0.50% QSP

Table 2: composition 2 based on siwak extract (Salvadore persica)

[0048] Soy and avocado unsaponifiables 6.00% 5-20% Siwak extract (Salvadore persica) 4.00% 3-10% Calcium phosphate 34.80% 20-40% Baking soda 9.00% 5-30% Citric acid 7.50% 5-30% Arginine 8.00% 6-12% Zinc Citrate 0.25% 0.1-1% Sorbitol 28.00% QSP Stevia 0.15% QSP Aroma 1.80% QSP Magnesium Stearate 0.50% QSP

Table 3: composition 3 based on cranberry extract

[0049] Soy and avocado unsaponifiables 6.00% 5-20% Cranberry extract 4.00% 3-10% Calcium phosphate 34.80% 20-40% Baking soda 9.00% 5-30% Citric acid 7.50% 5-30% Arginine 8.00% 6-12% Zinc Citrate 0.25% 0.1-1% Sorbitol 28.00% QSP Miraculin 0.15% QSP Aroma 1.80% QSP Magnesium Stearate 0.50% QSP

Table 4: composition 4 based on licorice extract

[0050] Soy and avocado unsaponifiables 6.00% 5-20% Licorice extract 4.00% 3-10% Calcium phosphate 34.80% 20-40% Baking soda 9.00% 5-30% Citric acid 7.50% 5-30% Arginine 8.00% 6-12% Zinc Citrate 0.25% 0.1-1% Eucalyptus Extract 2% 1-7% Sorbitol 26.00% QSP Aroma 1.80% QSP Magnesium Stearate 0.50% QSP

2. Method of making an oral care composition

[0051] All of the production steps as well as the working environment are governed by good manufacturing practices (GMP), the requirements of which are references for the manufacture of food supplements, foodstuffs, pharmaceutical and cosmetic products.

The mixing of the powders is carried out until a homogeneous mixture is obtained (tables 1-4). It is also possible, according to a non-limiting variant of the method, to carry out two mixtures separately in order to facilitate obtaining a homogeneous mixture of the powders allowing good compression thereof.

A first mixture comprises calcium diphosphate, plant extract (such as green tea, siwak, cranberry or licorice), L-arginine and the extract of unsaponifiables from soy and avocado. The whole is thoroughly mixed for at least 40 minutes in a low shear, free-fall mixer, the capacity of which allows homogeneous mixing, without de-mixing. For example, the use of a mixer with a total capacity of 400 L is suitable for a final production of 500 kg of an oral care composition according to the present invention.

The second mixture consists in mixing the zinc citrate beforehand with a small part of the Sorbitol, so that the small quantities of powders are distributed homogeneously in the final mixture. This step is carried out in a mortar of suitable volume for at least 5 minutes. The remainder of the Sorbitol, mortar mix, flavor and citric acid are added in a low shear free-fall mixer. The whole is thoroughly mixed for at least 40 minutes.

The two mixtures are then placed together in a low shear, free-fall mixer with the sodium hydrogencarbonate. The powders are again thoroughly mixed for at least 40 minutes.

Finally, to this mixture obtained, the magnesium stearate is added. Mixing is carried out in a low shear, free-fall mixer for at least 5 minutes. A preliminary sieving is carried out when the magnesium stearate is lumpy.

The particle size of the powders is controlled so that the mixture is homogeneous and the compression can be carried out under good conditions, thus avoiding numerous defective tablets.

3. Method of making an oral care composition in the form of a chewable tablet

The compression is carried out in a tablet press, the set of punches of which corresponds and makes it possible to obtain tablets of the target size. Adjustments are made so that the weight of each tablet meets the target value and the compression force results in non-brittle tablets that are not too hard so that it can easily deliquesce in the mouth. In this process, compression forces of more than 120N (Newtons) are used. Depending on the ingredients used and their % by mass relative to the total weight of a composition according to the invention, the compression forces can be between 130N and 170N, 130N and 160N, 130N and 150N, or even 130N and 140N. In particular, compression forces such as 120N, 125N, 130N, or 135N can be used.

In a particular case of the invention without being limiting, the compression pressure was set at 140N for green tea tablets of 984 mg 18 mm long by 8.5 mm wide and 6 mm thick.

All kinds of appropriate packaging for the good conservation of the composition according to the invention is envisaged and can vary according to the galenic form in which the composition is found. It may be, inter alia, a blister packaging, a bottle, or a sachet.

In a particular case of the invention without being limiting, the blistering is carried out using a blister machine whose mold allows the production of a blister adapted to the tablets made in the previous step. The temperature required for molding is adjusted to preserve the properties of the film, in particular in terms of its impermeability to water and to air, allowing optimal preservation of the tablets.

[0062] The blister is then filled with tablets and sealed with a film by means of an effect of pressure and heat.

[0063] Different pairs of materials can be used at this stage. Similarly, a blister can contain 1, 2 or more tablets depending on the mold chosen.

[0064] For example, the production of chewable tablets according to the present invention with green tea uses a blister pack using a PVC/PE/PCDC multilayer film for the molded sheet and an aluminum film for the sealing sheet.

4. Use of an oral care composition in the form of a chewable tablet

[0065] Tooth decay is formed by the localized chemical dissolution of tooth enamel by the action of organic acids formed from the fermentation of dietary carbohydrates by the biofilm microbiota covering the surface of the tooth (plaque dental). However, the concentration of acids in dental plaque must exceed a certain level to promote the demineralization of tooth enamel. There is consensus that no clinically relevant demineralization occurs at acid concentrations corresponding to pH >5.7.

[0066] Measuring the pH of dental plaque in healthy human volunteers using an indwelling electrode placed between the teeth is the most appropriate method for determining whether the consumption of a food or drink may lead to a potentially dangerous concentration of acids in dental plaque. This technique and its application have been described in detail (Imfeld, Th. N., Identification of Low Caries Risk Dietary Components, Monographs in Oral Science, Vol. 11, 198pp., H.M. Myers (ed), S. Karger AG, Basel , 1983).

[0067] In the context of the present invention, a test was carried out in which the pH was measured in volunteers, under a layer of dental plaque on the surface of the dental enamel. In this test, the pH of the dental plaque is recorded continuously for 110 minutes and after the absorption (at the time 22-30 minutes) of an oral care composition in the form of a chewable tablet.

The pH measurements were carried out on a subject with dental plaque of 0 days for the measurement of the erosive potential and on another subject with dental plaque of 5 days for the measurement of the cariogenic potential. During the test, pH measurement method checks were performed on both subjects at certain times by rinsing with water (W), chewing paraffin (PC), or giving them a 10% sucrose (sucrose) solution. These checks validate the pH measurement method and demonstrate the proper functioning of the electrodes.

The curve obtained from the subject without dental plaque demonstrates that the consumption of the tested product is not associated with an acid exposure and therefore does not present an erosive potential of the dental enamel (cf. figures 1 and 2, period between 30 min and 60 min after use of the composition).

[0070] The composition tested is also not associated with a drop in pH below 5.7 at the level of the dental plaque of the subject with dental plaque for 5 days (cf. FIG. 2, period between 30 min and 60 min after use of the composition). Consumption of the composition according to the invention therefore has no cariogenic potential.

[0071] The increase in plaque pH during water rinsing (W) and paraffin filling (PC) as well as the drop in pH below 5 after treatment with a 10 % demonstrate that the pH measurement at dental plaque is valid.

Claims (10)

1. Oral care composition comprising (i) 5 to 20% by mass of avocado and soy unsaponifiables, (ii) 3 to 10% by mass of plant extract, (iii) 6 to 12% by mass of arginine, (iv) 20 to 40% by mass of calcium phosphate, (v) 5 to 30% by mass baking soda, (vi) 5 to 30% by mass of citric acid, and (vii) 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition. 2. An oral care composition according to claim 1, further comprising at least one component selected from sorbitol, stevia, miraculin, eucalyptus extract, flavors, and magnesium stearate. 3. An oral care composition according to claim 1 or 2 comprising (i) 6% by mass of avocado and soy unsaponifiables, (ii) 4% by mass plant extract, (iii) 8% by mass of arginine, (iv) 34.8% by mass of calcium phosphate, (v) 9% by mass baking soda, (vi) 7.5% by mass of citric acid, (vii) 0.25% by mass of zinc citrate, (viii) 28% by mass of sorbitol, (ix) 0.15% by mass of stevia, (x) 1.8% by mass of aromas, and (xi) 0.5% by weight of magnesium stearate, relative to the total weight of the composition. 4. An oral care composition according to any preceding claim, wherein the herbal extract is selected from green tea, siwak, cranberry, cannabis or licorice extract or a mixture thereof. this. 5. An oral care composition according to any preceding claim, in chewable tablet, lozenge, powder, granule, gum, paste, gel, or cream form. 6. An oral care composition according to any preceding claim, wherein the composition is consumable and/or digestible after absorption. 7. Oral care composition according to any one of the preceding claims, in which the pH after administration of said composition is between 6 and 8. 8. Oral care composition according to any one of the preceding claims, for use in the treatment and/or prevention of oral diseases selected from the group comprising periodontal diseases, dental caries and halitosis. 9. An oral care composition according to any preceding claim for use as a toothpaste to reduce acid erosion of enamel, reduce biofilm and plaque generated by bacteria, reduce gingivitis, reduce halitosis, prevent tooth decay, prevent the formation of canker sores, and/or reduce dentin hypersensitivity. 10. A method of making an oral care composition according to any of claims 1-7, the method comprising (i) the mixture of 5 to 20% by mass of avocado and soy unsaponifiables, 3 to 10% by mass of plant extract, 6 to 12% by mass of arginine, 20 to 40% by mass of calcium phosphate, 5 to 30% by mass of sodium bicarbonate, 5 to 30% by mass of citric acid, 0.1 to 1% by mass of zinc citrate, relative to the total weight of the composition, and (ii) forming a tablet by compression.