CH710381A2 - Injection device for up-dosing and the distribution of a dose of a fluid product. - Google Patents

Abstract

The invention relates to an injection device for metering and dispensing a dose of a fluid product, comprising a housing (1) with several stops or with the housing (1) fixedly connected metering stop (2) with multiple stops, in particular with several Dosierstoppanschlägen, said Injection device comprises a multi-part piston rod (8, 9) detachable from the housing (1) or one of the metering stop (2) fixedly connected to the housing (1), the multi-part piston rod (8, 9) being a click sleeve (9). and an ejection element (8).

Description

The invention relates to an injection device for metering and for the distribution of a dose of a fluid product, in particular a medicament. The injection device comprises a multi-part piston rod with a click sleeve and an ejection element.

As used herein, the term "medicament" includes any fluid medical formulation suitable for controlled administration by an agent, such as e.g. a cannula or hollow needle, for example, comprising a liquid, a solution, a gel or a fine suspension containing one or more medicinal agents. Drug may be a single drug composition or a premixed or co-formulated multi-drug composition from a single container. Drug includes drugs such as peptides (eg, insulins, insulin-containing drugs, GLP-1 containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active agents, hormone or gene based drugs, nutritional formulas, enzymes, and other substances both in the art solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or oligonucleotides, antibodies or parts of antibodies and suitable base, excipients and carriers.

From the prior art, such injection devices are known. From WO 2013/178 512 A1 and US 8 821 451 B2 injection devices are known, wherein in these injection devices in each case the distribution of the dose is displayed.

It is an object of the invention to provide an alternative injection device wherein a dose can be adjusted and different dispensing positions can be displayed.

In the following, in an injection device, the proximal direction means the direction towards the housing-side end and the distal direction in an injection device means the direction toward the needle-side end.

The invention relates to an injection device for metering and for delivering a dose of a fluid product. The injection device comprises a housing with a plurality of stops or a metering stop firmly connected to the housing with a plurality of stops, in particular with a plurality of metering stop stops. The injection device has a multi-part piston rod which is detachable from the housing or one of the metering stops firmly connected to the housing, wherein the multi-part piston rod comprises a click sleeve and an ejection element. Furthermore, a spring mounted in the housing or in the housing firmly connected to the metering stop is provided, which acts on at least a part of the piston rod with a force. The ejection element may be rotatable relative to the housing or to the metering stop integral with the housing for adjusting a dose to be administered. The ejection element may comprise a Ausstosselementanschlag, which in a second state of the injection device, in which the multi-part piston rod is detached from the housing or from the fixedly connected to the housing Dosierstopp, in abutting contact with one of the plurality of stops of the housing or Dosierstopps, in particular one of the several Dosierstoppanschlägen is or is achievable. Furthermore, the injection device may preferably be designed such that in a first state of the injection device, in which the multi-part piston rod with the housing or with the housing firmly connected Dosierstopp is releasably connected, the click sleeve rotatably and / or axially fixed relative to the ejection element is arranged, and that in the second state of the injection device, the click sleeve is detachable from the ejection element and is axially movable relative to the ejection element, such that the click sleeve can be achieved in abutting contact with the ejection element.

Preferably, in the second state of the injection device, the click sleeve may be axially movable relative to the ejection element until the click sleeve is in abutting contact with the ejection element and generates an audible signal to indicate that the dose is being dispensed , This may serve to ensure that the user does not pull the hypodermic needle of the injection device out of the skin prior to the completion of the injection and thus completely administer the adjusted dose to be administered.

The Dosierstopp is axially fixed and rotatably connected to the housing. The Dosierstopp and the housing may be formed in two parts. Alternatively, the metering stop and the housing may be integrally formed. The housing or the metering stop fixed to the housing may surround the click sleeve. The click sleeve can be mounted axially movable on the ejection element.

In one embodiment of the injection device, the click sleeve may comprise a click sleeve holding member which in the first state of the injection device is engaged with a click sleeve holding counter element disposed on the ejection element, and the click sleeve holding member in the second state of the injection device out of engagement with the click sleeve holding counter-element is engageable. The click sleeve holding member may be formed as a click sleeve holding arm. The click sleeve retaining counter element may be formed as Ausstosselementaussparung.

Further, the housing or the dosing stop fixedly connected to the housing can be configured such that in the first state of the injection device the click-sleeve holding element can be held in engagement with the click-sleeve holding counter element. The housing or the dosing stop fixedly connected to the housing can also be designed such that in the second state of the injection device the click sleeve holding element can be brought out of engagement with the click sleeve holding counter element. For this purpose, the housing or the dosing stop firmly connected to the housing can have a recess, wherein the click-sleeve holding element can be brought into the recess. For each stop of the plurality of stops of the housing or fixedly connected to the housing Dosierstopps may be associated with a corresponding recess.

In another embodiment of the injection device, the click sleeve and the ejection element can form a cooperating guide slot, in particular each having a cooperating screw portion-shaped guide surface. Furthermore, the guide slot, in particular the two screw portion-shaped guide surfaces may be formed such that a relative rotation and / or a relative axial movement between the click sleeve and the ejection element is executable.

The injection device may further comprise a retaining sleeve, which is designed such that in the first state of the injection device relative rotation between the click sleeve and the ejection element can be prevented. The retaining sleeve may have a rib. The rib of the retaining sleeve can be designed such that the rib of the retaining sleeve can interact with the ejection element stop of the ejection element, in particular with a notch of the ejection element stop and with a groove arranged on the proximal end of the click sleeve. Relative rotational movement between the click member and the ejection member can be prevented by the engagement between the rib of the retainer sleeve and the notch of the ejection member stop and by the engagement between the rib of the retainer sleeve and the groove of the click sleeve. The retaining sleeve can be movable relative to the click sleeve in the axial direction, in particular in the proximal direction.

Further, in the second state of the injection device, the holding sleeve can be brought into abutting contact with the set stop of the housing or fixedly connected to the housing Dosierstopps. Due to the axial relative movement of the ejection element to the housing or to the housing firmly connected Dosierstopp can due to the stop contact between the rib of the retaining sleeve and a set dose corresponding stop of the housing or fixed to the housing Dosierstopp the retaining sleeve axially relative to move the ejection element in the proximal direction. The rib of the retaining sleeve can get out of engagement with the groove of the click sleeve. Due to the force of the spring acting on the click sleeve and the cooperating guide slot between the click sleeve and the ejection element, the click sleeve can rotate relative to the ejection element.

Preferably, the plurality of stops provided on the housing or on the metering stop fixedly connected to the housing may be formed in a staircase shape. By a rotational movement of the Ausstosselements relative to the housing or relative to the fixed to the housing Dosierstopp a step can be set as a stop to set the appropriate dose to be administered. The attacks can be designed as a stair member. Particularly preferably, the stops can be provided on the metering stop and be designed as Dosierstoppanschläge. Furthermore, guide ribs may be provided on the housing or on the dosing stop firmly connected to the housing, wherein the different lengths of the guide ribs may correspond to a dose to be administered. The Ausstosselementanschlag can be performed along a set guide rib of the housing or firmly connected to the housing Dosierstopp.

In a first state, the multi-part piston rod can be releasably connected to the housing or fixedly connected to the housing Dosierstopp. For this purpose, the ejection element stop provided on the ejection element can be in abutting contact with a stop surface arranged on the housing or with a stop surface arranged on the metering stop fixedly connected to the housing.

In a second state, the multi-part piston rod can be detached from the housing or from the metering stop firmly connected to the housing. For this purpose, the ejection element stop provided on the ejection element can be out of abutment contact with a stop surface arranged on the housing or with a stop surface arranged on the metering stop fixedly connected to the housing. To get out of abutment contact, the expelling member may be rotated relative to the housing or to the metering stop integral with the housing to adjust a dose to be administered.

The injection device may further preferably comprise a holding needle, wherein the holding needle may be received by the ejection element, and the holding needle may be acted upon by a force of the spring.

In this case, the retaining needle with the force of the spring relative to the click sleeve to be axially movable until the holding needle is in abutting contact with the click sleeve and generates an audible signal to indicate that the distribution of the dose begins. This may serve to indicate to the user that the administration of the fluid product is beginning.

The injection device may further comprise an adjusting sleeve. The adjustment sleeve may be axially fixedly connected to the housing or metering stop integral with the housing and rotatably mounted relative to the housing or to the metering stop integral with the housing to adjust a dose to be administered. Preferably, the adjustment knob may include a dose indicator, particularly in the form of numerals, letters or characters, to indicate to the user the adjusted dose to be administered by a window provided on the housing or by a metering stop fixedly attached to the housing.

The injection device may further comprise a sliding sleeve. In one embodiment of the injection device, the sliding sleeve can be arranged to be displaceable axially in the proximal direction relative to the housing or relative to the metering stop firmly connected to the housing. In a distal position of the sliding sleeve on the one hand a sliding sleeve edge of the sliding sleeve in the distal direction on the housing or on the fixedly connected to the housing Dosierstopp be releasably supported, and on the other hand, a Schiebehülsenschnapparm the sliding sleeve in the proximal direction of the housing or to the housing firmly connected Dosierstopp be releasably supported. The Schiebehülsenschnapparm the sliding sleeve and provided on the housing housing recess or provided on the fixedly connected to the housing Dosierstopp Dosierstoppausnehmung may be formed such that the Schiebehülsenschnapparm can engage in the Dosierstoppausnehmung. In a proximal position of the sliding sleeve, the sliding sleeve snap-in arm can engage in the housing recess provided on the housing or in the metering stop recess provided on the metering stop fixedly connected to the housing.

The sliding sleeve may further comprise a sliding sleeve lever, which may have a sliding sleeve cam, wherein on both sides of the sliding sleeve cam in each case a sliding sleeve locking wing can be arranged. The sliding sleeve lever may be designed to be elastic in the radial direction, in particular to be elastically tensionable, such that the sliding sleeve cam of the sliding sleeve lever has a setting sleeve groove arranged longitudinally on the jacket inner surface of the adjusting sleeve and an adjusting sleeve rib arranged longitudinally on the jacket inner surface of the adjusting sleeve, in particular over several Adjusting sleeve grooves of the adjusting sleeve and slide over several Einstellhülsenrippen the adjusting sleeve along.

The housing or the dosing stop firmly connected to the housing may have a support surface and an opening, wherein the support surface may be arranged distal to the opening. The sliding sleeve locking wing of the sliding sleeve can rest on the support surface such that a radial deflection of the sliding sleeve cam of the sliding sleeve lever can be prevented. By this support, a relative rotation between the adjusting and the housing or firmly connected to the housing Dosierstopp can be prevented. Furthermore, the sliding sleeve locking wings of the sliding sleeve can protrude into the opening of the housing or of the metering stop firmly connected to the housing in such a way that a radial deflection of the sliding sleeve cam of the sliding sleeve lever can be permitted. By this deflection, a relative rotation between the adjusting sleeve and the housing or the metering stop firmly connected to the housing can be permitted, wherein a dose to be administered can be set. In the distal position of the sliding sleeve, the sliding sleeve locking wings lie on the bearing surface of the housing or the dosing stop firmly connected to the housing. In the proximal position of the sliding sleeve, the sliding sleeve locking wings lie in the opening of the housing or the dosing stop firmly connected to the housing. Only when the sliding sleeve is axially displaced from a proximal position to a distal position, a relative rotation between the adjusting sleeve and the housing or the dosing stop firmly connected to the housing can be performed. This arrangement can certainly lead to the premixing of an active substance and a solvent of a multi-chamber carpule, in particular of a 2-chamber carpule, and / or priming of the injection device, wherein the injection device is vented, and / or axial play between the multi-chamber carpule, especially the 2-chamber carpule and a carpule holder or between the carpule holder and the housing is reduced or even eliminated.

To mix a drug contained in a first chamber with a solvent contained in a second chamber of a 2-chamber carpule, the recorded with the 2-chamber carpule carpule holder can be inserted into the interior of the housing. The carpule holder can be screwed into the housing via a threaded connection. After mixing, the carpule holder can be further guided or screwed into the housing, so that the sliding sleeve can be moved in the proximal direction.

To display the individual mixing movements, the carpule holder may have a mixing indicator device, in particular in the form of numbers, letters or characters. The mixing indicator of the carpule holder may be visible through a housing window provided on the housing, wherein it may be apparent to the user in which position the injection device is. Furthermore, the housing can have a housing opening, in particular a plurality of housing openings, into which one or more carpule holder latching arms provided on the carpule holder can engage in order to form a push-back or reverse-rotation lock, so that a secure administration of the fluid product can be ensured.

In another embodiment of the injection device, the sliding sleeve may be in a proximal position, wherein the sliding sleeve is axially fixed relative to the housing or to the metering stop firmly connected with housing. The injection device may comprise a holding element for holding and / or fixing and / or positioning a carpule, in particular a single-chamber carpule. Preferably, a carpule can be kept free of play on or in a carpule holder. The carpule may comprise in a chamber a fluid product to be administered. The carpule can be held in the carpule holder on the distal side in axial stop contact and on the proximal side by means of the holding element. In this way, manufacturing and assembly tolerances can be compensated. The holding element may preferably be formed elastically deformable. The retaining element may have a ring element. The ring element may be sleeve-shaped. The ring element may further preferably be cylindrical. On the ring member, a first and a second spring seat may be provided. The ring member may comprise a plurality of brackets and a plurality of connecting webs, wherein the first spring seat may be connected via the plurality of brackets and the plurality of connecting webs with the second spring seat. The brackets extend in the circumferential direction, wherein they can be formed curved against distal or against proximal. The first spring seat may be connected via a first connecting web to a first bracket, wherein the first bracket may be connected via a second connecting web to a second bracket and the second bracket via a second connecting web to the second spring seat. The first and second brackets can form elastic bending arms. The first and the second bracket can thus protrude via the connecting webs in the axial direction of the first and of the second spring seat. Alternatively, a different number of brackets, connecting webs and spring seats may be provided on the holding element. Furthermore, the ring element can also have a different configuration, provided that the ring element along the axial axis can be claimed for pressure. The holding element may have a projection, a clamping element and a spring element. The projection and the clamping element can be connected via the spring element with the holding element. The projection may protrude radially outwards from the spring element, and the clamping element may project radially inwards from the spring element. The spring element may be arranged on the first spring seat, Furthermore, the holding element may comprise a cam, wherein the cam may be arranged on the second spring seat and may protrude radially outwardly. The carpule holder may further in a first position, in which the carpule is movably received in the carpule holder, and in a second position, wherein the carpule is received and secured in the carpule holder, hold the holding member at least partially in an annular gap between the carpule holder and the carpule , The holding element may be designed such that the holding element in the second position of the carpule holder can hold the carpule axially free of play relative to the carpule holder. In this case, the carpule can be supported in the distal direction on or in the carpule holder and in the proximal direction on the holding element. In the first position of the carpule holder, the projection of the holding element can be latched into a recess of the carpule holder. The connection between the projection of the retaining element and the recess of the carpule holder may be detachable. In the second position of the carpule holder, the projection of the holding element can be pressed out of the recess of the carpule holder, wherein the arranged on the second spring seat cam of the holding element can pass into the recess of the carpule holder to elastically bias the holding member. The connection between the cam of the retaining element and the recess of the carpule holder may be formed insoluble. The clamping element of the holding element can hold or embrace a proximal carpule edge of the carpule in the second position of the carpule holder. The carpule can be kept free of play between the carpule holder and the holding element in the carpule holder. In order to move from the first position to the second position of the carpule holder, a tool, for example a pushing or pushing device, can act on the second spring seat of the holding element such that the holding element is moved axially in the distal direction relative to the carpule holder. Furthermore, the carpule holder can be glued or welded to the housing of the injection device. Alternatively, other fastening means between the carpule holder and the housing may be provided.

The injection device may further comprise a trigger sleeve. The release sleeve can be axially fixed and rotatably connected to the adjusting sleeve. The release sleeve and the adjusting sleeve may alternatively be formed in one piece. Furthermore, the injection device may comprise a trigger button. The trigger button may be arranged to be axially movable in the distal direction relative to the housing or to the dosing stop firmly connected to the housing.

The release button and the release sleeve may be formed such that the release button is axially movable relative to the release sleeve in the distal direction and axially in the proximal direction can be blocked. For this purpose, a corresponding ratchet connection in the form of one or more recesses and one or more snap arms may be provided on the release button and on the release sleeve. The ratchet connection between the trigger button and the trigger sleeve may serve to allow the user to move the trigger button only once in the distal direction, or the user may administer a set dose only once.

In an initial position in which the injection device is delivered, it can be provided that an axial movement of the release button in the distal direction relative to the housing or to the fixedly connected to the housing Dosierstopp can be prevented. In a position with set dose of the injection device, it can be provided that an axial movement in the distal direction relative to the housing or to the fixedly connected to the housing Dosierstopp is possible. For this purpose, the release button may have a tab which is supported on a rib of the housing or on a rib of the metering stop fixedly connected to the housing, in particular supported on a wide rib of the housing or on a wide rib of the metering stop firmly connected to the housing, wherein the support is releasable by a relative rotation between the release button and the housing or the metering stop fixedly connected to the housing. The housing or the dosing knob fixedly connected to the housing can have further ribs, in particular narrow ribs, wherein the tab of the trigger button can slide along a narrow rib of the housing or a narrow rib of the dosing stop firmly connected to the housing.

On the holding needle may be provided a groove which may be in engagement with a holding arm of the release sleeve to hold the holding needle in a proximal position. Further, a recess may be provided on the release button to receive the support arm, so that the support arm of the release sleeve is disengaged from the holding needle can be brought.

The invention will be described below with reference to several figures. The features disclosed in this case each individually and in combination advantageously continue the invention. Show it: <Tb> FIG. 1 <SEP> is an exploded view of a first embodiment of an injection device according to the invention <Tb> FIG. 2a is a longitudinal sectional view of the injection device of FIG. 1 in a first state, in which the multi-part piston rod (8, 9) is releasably connected to the dosing stop (2), and in an initial position, in which the injection device is delivered the longitudinal sectional view of the drawn in Fig. 2d section line A-A corresponds. <Tb> FIG. 2b is a longitudinal sectional view of the injection device according to FIG. 2a, wherein the longitudinal sectional view corresponds to the section line B-B shown in FIG. 2e. <Tb> FIG. 2c <SEP> is a cross-sectional view of the injection device of FIG. 1 in the first state in which the multi-part piston rod (8, 9) is detachably connected to the dosing stop (2), and in the starting position in which the injection device is delivered the cross-sectional view of the drawn in Fig. 2a section line C-C corresponds. <Tb> FIG. 3 is a longitudinal sectional view of the injection device of FIG. 1 in the first state in which the multi-piece piston rod (8, 9) is releasably connected to the metering stop (2), in a mixed position in which the solvent is from a second chamber (11c) has been diverted into a first chamber (11d) of a carpule (11). <Tb> FIG. 4a is a longitudinal sectional view of the injection device of FIG. 1 in the first state in which the multi-part piston rod (8, 9) is detachably connected to the dosing stop (2) in a primed position in which the injection device is vented the longitudinal sectional view of the drawn in Fig. 2d section line A-A corresponds. <Tb> FIG. 4b <SEP> is a longitudinal sectional view of the injection device according to FIG. 4a, wherein the longitudinal sectional view corresponds to the section line B-B shown in FIG. 2e. <Tb> FIG. 4c is a cross-sectional view of the injection device of FIG. 1 in the first state in which the multi-part piston rod (8, 9) is detachably connected to the metering stop (2) and in the primed position in which the injection device is vented, FIG. wherein the cross-sectional view corresponds to the section line D-D shown in FIG. 4a. <Tb> FIG. 4d <SEP> is a perspective view of a distal part of the dosing stop (2) and a proximal part of the sliding sleeve (3) of the injection device from FIG. 1 in the first state in which the multi-part piston rod (8, 9) with the dosing stop (2) is detachably connected, in the primed position, in which the injection device is vented, wherein the adjusting sleeve (4) is recessed. <Tb> FIG. 5a is a longitudinal sectional view of the injection device of FIG. 1 in the first state in which the multi-part piston rod 8, 9 is detachably connected to the metering stop 2, and in a dose-adjusted position, the longitudinal sectional view of FIG Fig. 2d drawn section line A-A corresponds. <Tb> FIG. 5b <SEP> is a perspective view of the dosing stop (2), the proximal part of the sliding sleeve (3) and a distal part of the trigger button (6) of the injection device of FIG. 1 in the first state in which the multi-part piston rod (8, 9) is releasably connected to the dosing stop (2), and set in the dose position, wherein the adjusting sleeve (4) is recessed. <Tb> FIG. Fig. 6a <SEP> is a longitudinal sectional view of a proximal part of the injection device of Fig. 1 in the first state in which the multi-part piston rod (8, 9) is detachably connected to the dosing stop (2) and in a dose triggered position, the longitudinal sectional view the drawn in Fig. 2e section line B-B corresponds. <Tb> FIG. Fig. 6b is a perspective view of the dosing stop (2) and the distal part of the trigger button (6) of the injection device of Fig. 6a with the adjusting sleeve (4) recessed. <Tb> FIG. FIG. 6c shows a longitudinal sectional view of a proximal part of the injection device from FIG. 6a, the longitudinal sectional view corresponding to the section line A-A drawn in FIG. 2d. <Tb> FIG. Fig. 7a is a longitudinal sectional view of a proximal part of the injection device of Fig. 1 in a second state in which the multi-part piston rod (8, 9) is released from the dosing stop (2) and the click sleeve (9) from the ejection element (8) is releasable and is axially movable relative to the ejection element (8), such that the click sleeve is in stop contact with the ejection element tangible, the longitudinal sectional view of the drawn in Fig. 2d section line A-A corresponds. <Tb> FIG. Fig. 7b is a longitudinal sectional view of a proximal part of the injection device of Fig. 1 in the second state in which the multi-piece piston rod (8, 9) is disengaged from the dosing stop (2) and the click sleeve (9) from the ejection element (8) is releasable and is axially movable relative to the ejection element (8), such that the click sleeve in abutting contact with the ejection element can be achieved, and the click sleeve outer surface (9d) of the click sleeve (9) in abutting contact with the Ausstosselementinnfläche (8f) of the Ausstosselements (8), wherein the longitudinal sectional view corresponds to the drawn in Fig. 2d section line A-A. <Tb> FIG. Fig. 8a <SEP> is a development view of a stair member (2k) in cooperation with an ejection stopper (8a) of an ejection member (8) and a click-stop member (9a), for example in the form of a click sleeve holding arm (9a) of a click sleeve (9) ) of the injection device of Fig. 1 before a distribution of a medium dose, for example. <Tb> FIG. Fig. 8b is a development view of a stair member (2k) in cooperation with an ejection stop (8a) of an ejection member (8) and a click-stop member (9a), for example in the form of a click sleeve holding arm (9a) of a click sleeve (9) ) of the injection device of Fig. 1 after a release of a medium dose, for example. <Tb> FIG. 9 shows an exploded view of a second embodiment of an injection device according to the invention <Tb> FIG. Fig. 10a is a longitudinal sectional view of the injection device of Fig. 9 in a first state in which the multi-part piston rod (8, 9) is releasably connected to the dosing stop (2) and in an initial position in which the injection device is delivered The longitudinal sectional view corresponds analogously to the section line A-A drawn in FIG. 2d. <Tb> FIG. 10b <SEP> is a longitudinal sectional view of the injection device according to FIG. 10a, wherein the longitudinal sectional view corresponds analogously to the section line B-B shown in FIG. 2e. <Tb> FIG. 11a <SEP> is a perspective view of a third embodiment of an injection device according to the invention in a first state, in which the multi-part piston rod (8, 9) with the metering stop (not shown) is detachably connected, and in the starting position, in which the injection device delivered is shown, wherein only the multi-part piston rod (8, 9), the holding needle (7), the spring (12) and a holding sleeve (14) are shown. <Tb> FIG. 11b <SEP> is a longitudinal sectional view of the injection device according to FIG. 11a, wherein only the multi-part piston rod (8, 9), the holding needle (7), the spring (12) and the holding sleeve (14) are shown. <Tb> FIG. 12 is a longitudinal sectional view of the injection device of the third embodiment of an injection device according to the invention in the first state, in which the multi-part piston rod (8, 9) is detachably connected to the metering stop (not shown), and in a dose-triggered position. <Tb> FIG. Fig. 13a is a perspective view of the third embodiment of an injection device according to the invention in the second state in which the multi-part piston rod (8, 9) is released from the dosing stop (not shown) and the click sleeve (9) of Fig. 13a Ejection element (8) is releasable and is axially movable relative to the ejection element (8), such that the click sleeve is achievable in abutting contact with the ejection element, and the click sleeve outer surface (9d) of the click sleeve (9 ) in abutting contact with the Ausstosselementinnfläche (8f) of the Ausstosselements (8), wherein only the multi-part piston rod (8, 9), the retaining needle (7), the spring (12) and the retaining sleeve (14) are. <Tb> FIG. 13b <SEP> is a longitudinal sectional view of the injection device according to FIG. 13a, wherein only the multi-part piston rod (8, 9), the holding needle (7), the spring (12) and the holding sleeve (14) are shown.

In Fig. 1 is an exploded view of a first embodiment of the inventive injection device is shown. The injection device comprises a housing (1) and with the housing (1) axially fixed and rotationally fixed Dosierstopp (2). For this purpose, a metering stop cam (2a) provided on the metering stop (2) is engaged in a housing recess (1a) provided on the housing (1). Furthermore, a metering stop edge (2b) provided on the metering stop (2) is in abutting contact with a proximal housing stop (2b, 1b) provided on the housing. In addition, at the dosing stop (2) a Dosierstopprippe (2c), in particular two Dosierstopprippen (2c) is provided which in a provided on a shell inner surface housing notch (not visible) of the housing (1), in particular in two provided on a shell inner surface housing notches (not visible) protrude. The injection device further comprises a sliding sleeve (3). The sliding sleeve (3) is rotatably connected to the housing (1). For this purpose, a sliding sleeve rib (3a) provided on the sliding sleeve (3) projects into a housing groove provided on the shell inner surface (FIGS. 2a, 1g). The sliding sleeve (3) is arranged axially displaceable in the proximal direction relative to the housing (1) and the metering stop (2). A sliding sleeve edge (3b) of the sliding sleeve (3) can on the one hand be detachably supported axially in the distal direction on a distal housing stop (2b, 1c) of the housing (1), and on the other hand a sliding sleeve snap arm (3c) of the sliding sleeve (3) can axially in the proximal direction on a Dosierstoppsperranschlag (2e) of Dosierstopps (2) be releasably supported. The Schiebehülsenschnapparm (3c) of the sliding sleeve (3) and provided on the Dosierstopp (2) Dosierstoppausnehmung (2i) may be formed such that the Schiebehülsenschnapparm (3c) in the Dosierstoppausnehmung (2i) can engage. The injection device further comprises an adjusting sleeve (4). The adjusting sleeve (4) is axially fixed to the Dosierstopp (2) and the housing (1). For this purpose, the adjusting sleeve (4) has an adjusting sleeve projection (Fig. 2a; 4a), which is in abutting contact with a dosing stop ring groove (2d) provided on the dosing stop (2). Further, an adjusting sleeve ring edge (4b) is provided on the adjusting knob (4), which is in abutting contact with a housing edge (1d) attached to the housing (1). The adjustment sleeve (4) is rotatably mounted relative to the housing (1) and the metering stop (2) to adjust a dose to be administered. The adjusting knob (4) may have a dose indicator (not shown), in particular in the form of numbers, letters or characters. The dose indicator (not shown) of the adjusting knob (4) may be visible through a housing dose window (1i) provided on the housing (1), which may be visible to the user as to which dose to dose. Furthermore, the sliding sleeve (3) has a sliding sleeve lever (3d), which comprises a sliding sleeve cam (3d), wherein a sliding sleeve locking wing (3d) is arranged on both sides of the sliding sleeve cam (3d '). The sliding sleeve lever (3d) is elastic in the radial direction, in particular elastically tensioned, in such a way that the sliding sleeve cam (3d) of the sliding sleeve lever (3d) has an adjustment sleeve groove (4c) arranged longitudinally on the shell inner surface of the adjusting sleeve (4) and via a on the shell inner surface of the adjusting sleeve (4) arranged in the longitudinal direction Einstellhülsenrippe (4f), in particular over several Einstellhülsennuten (4c) and over several Einstellhülsenrippen (4f) can slide along. Furthermore, the metering stop (2) comprises a metering stop bearing surface (2o) and a metering stop opening (2p), wherein the metering stop bearing surface (2o) is arranged distally to the metering stop opening (2p). The sliding sleeve locking wings (3d) of the sliding sleeve (3) can rest on the metering stop bearing surface (2o) such that a radial deflection of the sliding sleeve cam (3d) of the sliding sleeve lever (3d) can be prevented. Thus, a relative rotation between the adjusting sleeve (4) and the housing (1) and the Dosierstopp (2) can be prevented. Further, the sliding sleeve locking vanes (3d) may be the sliding sleeve (3) in the metering stop opening (2p) such that radial deflection of the sliding sleeve cam (3d) of the sliding sleeve lever (3d) may be allowed, with relative rotation between the adjustment sleeve (4) and the housing (1) and the Dosierstoppe (2) is executable. The injection device further comprises a triggering sleeve (5). The release sleeve (5) is axially fixed and rotatably connected to the adjusting sleeve (4). For this purpose, the release sleeve (5) has a release sleeve cam (5a) which is in abutting contact with an adjustment sleeve bead (Fig. 2b; 4d) of the adjustment sleeve (4) and a trigger sleeve stop (5b) which is in abutting contact with an adjustment sleeve stopper (Fig. 2b , 4e) of the adjusting sleeve (4). Furthermore, the release sleeve (5) comprises a release sleeve rib (5c), in particular two release sleeve ribs (5c), which is in engagement with a release sleeve twist lock groove (not shown) attached to a shell inner surface of the adjustment sleeve (4). The injection device further comprises a trigger button (6). The trigger button (6) is rotatably connected to the adjusting sleeve (4). For this purpose, a trigger button rib (6a) attached to the release button (6) is in engagement with a release sleeve groove (not shown) provided on a shell inside of the trigger sleeve (5). The trigger button (6) is arranged to be movable axially relative to the housing (1) and the dosing stop (2) in the distal direction. A trigger sleeve snap arm (5d) attached to the trigger sleeve (5) may be axially supported distally on an edge of the trigger button rib (6a). The trigger button (6) further comprises a distal trigger button recess (6b) and a proximal trigger button recess (6b), these two trigger button recesses (6b ', 6b ») of the trigger button (6) and the trigger sleeve snap arm (5d) of the trigger sleeve (5 ) are formed such that the trigger button (6) relative to the Auslösehülsenschnapparm (5d) of the trigger sleeve (5) is axially movable in the distal direction and can be blocked in the proximal direction. A trigger button edge (6e) of a trigger button guide tab (6d) of the trigger button (6) may be supported on a dosing stop edge (2f) of a wide dosing stop ratchet (2g) of the dosing stop (2), the support being supported by relative rotation between the trigger button (6). and the Dosierstopp (2) is releasable. The trigger button (6) further comprises a trigger button guide tab groove (6e) disposed on a shell inner surface of the trigger button guide tab (6d) of the trigger button (6). This release button guide tab groove (6e) of the release button (6) is designed so that it can slide along a narrow dosing stop rib (2g) provided on the dosing stop (2). The metering stop (2) preferably comprises a plurality of narrow metering stopper lips (2g). The release button guide tongue (6d) can be axially guided between the two release sleeve ribs (5c) of the release sleeve (5). The injection device further comprises a holding needle (7) and a spring (12). The spring (12) is prestressed at the distal end on a retaining needle stop (7a) provided on the retaining needle (7) and supported on the trigger sleeve support surface (Fig. 2a; 5e) at the proximal end on a trigger sleeve (5). The retaining needle (7) further comprises a retaining needle groove (7b), in particular two retaining needle grooves (7b). The release sleeve (5) further comprises a trigger sleeve holding arm (Figures 2b; 5g), in particular two trigger sleeve holding arms (Figures 2b; 5g) which are adapted to fit into the retaining needle groove (7b), particularly the two retaining needle grooves (7b). can engage to hold the holding needle (7) relative to the housing (1) can. Furthermore, a release button recess (6f), in particular two release button recesses (6f), which can receive the release sleeve retaining arm (FIGS 2 b), in particular the two Ausrösehülsenhaltearme (Fig 2b, 5g) out of engagement with the retaining needle groove (7b), in particular the two retaining needle grooves (7b) of the retaining needle (7) reach. The injection device further comprises a multi-part piston rod (8, 9). The multi-part piston rod (8, 9) comprises an ejection element (8). The ejection element (8) is arranged to be movable axially in the distal direction relative to the housing (1) and the metering stop (2). For this purpose, an ejection element stop (8a) with an ejection element stop notch (8b) is provided on the ejection element (8). A metering stop guide rib (Figs. 8a, 2j, 2j, 2j) provided on the metering stop (2) may be guided in the discharge stopper notch (8b) of the discharge stopper (8a). Preferably, the metering stop (2) may include a plurality of metering stop guide ribs (Figures 8a, 2j, 2j, 2j) with a length of the metering stop guide rib (Figures 8a, 2j, 2j, 2j). corresponds to an adjustable dose. The ejection element stop (8a) can be brought into abutting contact with a metering stop staircase element (FIG. 8a; 2k) provided on the inside of the metering stop (2), in particular with a metering stop stop (FIG. 8a, 2l, 2l) corresponding to the selected dose. 2l) be brought. The dosing stop stair member (Figure 8a, 2k) has various Dosierstoppanschläge (Fig 8a, 2l, 2l, 2l), wherein by a rotational movement of the Ausstosselements (8) relative to the housing (1) or Dosierstopp ( 2) a step is set as a stop to set each dose to be administered. The various metering stop stops (FIGS. 8a, 2l, 2l, 2l) may correspond, for example, to a small, medium or large dose. In order to prevent axial relative movement between the ejection element (8) and the housing (1) and the Dosierstoppe (2), the Ausstosselementanschlag (8a) of the Ausstosselements (8) in abutting contact with a on the inner surface of the Dosierstopps (2) arranged Dosierstoppanschlagsfläche (Fig 2a, 2h) be brought. The ejection element (8) further comprises an ejection element shoulder (8c). The ejection element shoulder (8c) is supported axially in the proximal direction on a first metering stop shoulder (FIG. 2b, 2m) provided on the inner shell surface of the metering stop. The ejection element (7) is rotatably connected to the trigger sleeve (5). For this purpose, the ejection element (8) has a rib (not shown), in particular two Ausstosselementrippen (not shown), which are in engagement with a on the release sleeve (5) provided Auslösehülsennut (5f). The multi-part piston rod (8, 9) further comprises a click sleeve (9). The click sleeve (9) is mounted on the ejection sleeve (8) axially movable in the distal direction. For this purpose, a click sleeve holding element (9a), for example in the form of a click sleeve holding arm (9a) is provided on the click sleeve (9) which engages with a click sleeve counter element (8d) provided on the ejection element (8) may be in the form of a Ausstosselementaussparung (8d). The click sleeve holding element (9a), in particular the click sleeve holding arm (9a) is elastic, in particular elastically tensioned. The click sleeve holding member (9a) may further be engageable with a metering stop recess (2n) provided on the shell inner surface of the metering stop (2), the click sleeve holding member (9a) of the click sleeve (9) being disengaged from the click sleeve counter member (9). 8d) of the ejection element can be brought. At the dosing stop (2) a plurality of Dosierstoppaussparungen (2n) are provided, which correspond to a set dose. The click sleeve (9) further comprises a click sleeve shoulder (9e). The click sleeve shoulder (9e) is supported axially in the proximal direction on a second metering stop shoulder (FIGS. 2a, 2m) provided on the inner shell surface of the metering stop. The click sleeve (9) is non-rotatably connected to the ejection element (8). For this purpose, the click sleeve (9) has a click sleeve anti-rotation locking surface (9b) which is in engagement with a Ausstosselementverdrehsicherungsfläche (8e) provided on the Ausstosselement (8). The click sleeve (9) has at its distal end a click sleeve inner surface (Fig. 2a; 9c) and a click sleeve outer surface (9d). The retaining needle stop (7a) of the retaining needle (7) can come into abutting contact with the click sleeve inner surface (Fig 2a, 9c) of the click sleeve, wherein an acoustic noise, in particular a acoustically odertaktil perceptible noise indicating that the injection process started has, can arise. The click-sleeve outer surface (9d) of the click sleeve (9) can come into abutting contact with a Ausstosselementinnenflache (8f) provided on the Ausstosselement (8), wherein an acoustically or tactile perceptible noise, in particular an acoustic noise indicating that the Injection process is completed, can arise. The injection device further comprises a carpule holder (10), in which a carpule (10) is received. The carpule (11) is designed as a 2-chamber carpule (11), which has a first chamber (Fig. 2a; 11a) bounded by a first plug (Figs. 2a; 11b) and a second chamber (Fig 2a, 11c) bounded by the first plug (Figures 2a, 11b) and a second plug (Figures 2a, 11d). The carpule holder (10) comprises a cartridge holder external thread (10a) which is engaged in a housing internal thread (le) provided on the housing (1). In the periphery of the wall of the 2-chamber cartridge (11), a bypass (Fig. 2b, 11e) is provided, through which solvent from the second chamber (Fig. 2a; 11c) into the first chamber containing an active substance (Fig. 2a ; 11d) can be redirected. To display the individual mixing movements, the carpule holder (10) may have a mixing display device (10b), in particular in the form of numbers, letters or characters. The blending indicator (10b) of the carpule holder (10) may be visible through a housing window (1f) provided on the housing (1), which may be visible to the user in which position the injection device is. Furthermore, the housing (1) can have a housing opening (1h), in particular a plurality of housing openings (1h) into which one or more carpule-holder latching arms (10c) provided on the carpule holder (10) can engage in order to form a push-back or reverse-rotation lock, so that a safe administration of the fluid product can be ensured. Provided at the distal end of the carpule holder (10) is a needle connection element (1 Od), which is provided for releasable attachment of an injection needle (not shown). At the proximal end of the carpule holder (10), a carpule holder edge (10e) is provided. The injection device may further comprise a closure cap (not shown), which may be connectable via a detachable connection with the carpule holder (10).

In Fig. 2a is a longitudinal sectional view of the injection device of Fig. 1 in a first state in which the multi-part piston rod (8, 9) with the metering stop (2) is detachably connected, and in an initial position in which the Injection device is delivered, shown, wherein the longitudinal sectional view of the drawn in Fig. 2d section line A-A corresponds. Furthermore, FIG. 2b shows a longitudinal sectional view of the injection device according to FIG. 2a, the longitudinal sectional view corresponding to the section line B-B drawn in FIG. 2e. The multi-part piston rod (8, 9) comprises the click sleeve (9) and the ejection element (8). The click sleeve holding member (9a) provided on the click sleeve (9), particularly the click sleeve holding arm (9a) is engaged with the click sleeve holding counter member (8d) disposed on the ejection member (8), particularly with the ejection member recess (8d ). The click sleeve (9) is rotatably and / or axially fixed relative to the ejection element (9). The metering stop (2) is configured such that the click sleeve holding member can be held in engagement with the click sleeve holding counter member. The click sleeve holding member (9a), particularly the click sleeve holding arm (9a) is elastically biased into engagement with the click sleeve holding counterpart member (8d), in particular with the ejection element recess (8d) held by a skirt inner surface of the metering stop (2). The Ausstosselementanschlag (8a) of the Ausstosselements (8) is in abutting contact with the arranged on the inner surface of the Dosierstopps (2) Dosierstoppanschlagsfläche (2h). As a result, the multi-part piston rod (8, 9), in particular the click sleeve (9) and the ejection element (8) with the Dosierstopp (2) is detachably connected. The two Ausrösehülsenhaltearme (5g) of the trigger sleeve (5) are in engagement with the two retaining needle grooves (7b) of the holding needle (7). The holding needle (7) is provided with a preloaded spring (12) which is supported at the distal end on the retaining needle stop (7a) of the retaining needle (7) and at the proximal end on the Auslösehülsenabstützfläche (5e) of the trigger sleeve (5) with an in apply force to the distal direction. The holding needle stopper (7a) of the holding needle (7) is of click sleeve inner surface (9c) of the click sleeve (9) and the click sleeve outer surface (9d) of the click sleeve (9) is of the ejection element inner surface (8f) of the ejection element (8f). 9) spaced. The trigger sleeve snap arm (5d) of the trigger sleeve (5) is located in the distal trigger button recess (6b '). The sliding sleeve edge (3b) of the sliding sleeve (3) is detachably supported distally on the distal housing stop (1c) of the housing (1) and the sliding sleeve snap arm (3c) of the sliding sleeve (3) is axially in the proximal direction on the metering stop stop (2e). the Dosierstopps (2) releasably supported. The cartridge holder (10) is engaged with the housing (1) via the threaded connection between the cartridge holder male thread (10a) and the housing internal thread (1e). The carpule holder edge (10e) arranged at the proximal end of the carpule holder (10) is at a distance from the sliding sleeve edge (3b) of the sliding sleeve (3). As can be seen in FIG. 2c, the sliding sleeve locking wings (3d) of the sliding sleeve (3) rest on the metering stop bearing surface (2o) of the metering stop (2) in order to provide radial deflection of the sliding sleeve cam (3d) of the sliding sleeve lever (3d). to prevent. Further, the trigger button edge (6e) of the trigger button guide tab (6d) of the trigger button (6) is abutted against a metering stop edge (2f) of the wide metering stopper rib (2g) of the metering stop (2) to prevent triggering of the injection device. The mixing display device (10b), in particular a corresponding number, a corresponding letter or another corresponding character of the carpule holder (10), can be seen in such a way by the housing window (1f) provided on the housing (1) that the user is informed that the Injection device is in the starting position. Further, the Karpulenhalterrastarm (11c) of the carpule holder (11) in a housing opening (1h) of the housing (1), in particular in a arranged at the distal end of the injection device housing opening (1h) of the housing (1) engaged.

In the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is releasably connected, and shown in a blended position, in FIG .. 3 is a longitudinal sectional view of the injection device of FIG which the solvent has been diverted from a second chamber (11c) into a first chamber (11d) of a carpule (11). An injection needle (not shown) can be placed on the needle connection element (1 Od) of the cartridge holder. From the initial position according to FIG. 2 a and FIG. 2 b, the carpule holder (10) accommodated with the carpule (11) is introduced into the interior of the housing (1) in the proximal direction relative to the housing (1). For this purpose, the carpule holder (10) via the threaded connection between the Karpulenhalteraussengewinde (10a) and the housing internal thread (1e) is screwed into the housing (1). By inserting or screwing in the carpule holder (10), the distal end of the ejection element (8) strikes the second plug (11d) of the carpule (11) and pushes it in the distal direction while continuing the insertion movement or screwing movement within the carpule (11) , Thereby, first, the driving force is transmitted to the first plug (11b) by the solvent in the second chamber (11c), so that both plugs (11b, 11d) are driven distally. As soon as the first plug (11b) comes to rest in the area of the bypass (11e) of the carpule (11), the first plug (11b) remains at rest relative to the carpule (11). The second plug (11 d), however, is further driven, so that the solvent from the second chamber (11 c) via the bypass (11 e) into the first chamber (11 a) and can solve a drug located there. The second plug (11d) is driven until it hits the first plug (11b). This achieves the blended position. During this process, the carpule holder (10) continues to be inserted or screwed into the housing (1). The mixing display device (10b), in particular a corresponding number, a corresponding letter or another corresponding character of the carpule holder (10), can be seen in such a way by the housing window (1f) provided on the housing (1) that the user is informed that the Injection device is in the mixed position. Further, the Karpulenhalterrastarm (11c) of the carpule holder (11) in a housing opening (1 h) of the housing (1), in particular in an arranged between the distal end and proximal end of the injection device housing opening (1h) of the housing (1) engaged.

In the Fig. 4a is a longitudinal sectional view of the injection device of Fig. 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and in a primed position, in which the injection device is vented, shown, wherein the longitudinal sectional view of the drawn in Fig. 2d section line A-A corresponds. Furthermore, a longitudinal sectional view of the injection device according to FIG. 4a is shown in FIG. 4b, the longitudinal sectional view corresponding to the section line B-B drawn in FIG. 2e. From the blended position according to FIG. 3, the carpule holder (10) is further inserted or screwed in the proximal direction into the housing (1). The carpule holder edge (10e) arranged at the proximal end of the carpule holder (10) thereby comes into abutting contact with the sliding sleeve edge (3b) of the sliding sleeve (3), wherein the sliding sleeve (3) is driven in the proximal direction. As shown in FIG. 4c and in FIG. 4d, the sliding sleeve locking wings (3d) of the sliding sleeve (3) reach into the metering stop opening (2p) of the metering stop (2) to provide radial deflection of the sliding sleeve cam (3d). to allow the sliding sleeve lever (3d). During a further advance of the carpule holder (10) relative to the housing (1), the two plugs (11b, 11d) are simultaneously displaced further in the distal direction. By means of the injection needle (not shown), in particular, superfluous air can therefore escape from the first chamber (11a). In addition, any axial play between the carpule (11) and the carpule holder (10) or between the carpule holder (10) and the housing (1) may be reduced or even eliminated in order to ensure safe and accurate administration of the fluid product ,

In the Fig. 5a is a longitudinal sectional view of the injection device of Figure 1 in the first state, in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and shown in a dose position, wherein the longitudinal sectional view corresponds to the section line A-A shown in FIG. 2d. To set a dose to be administered, the user rotates the adjustment sleeve (4) relative to the housing (1) and metering stop (2) until the corresponding dose marker of the dose indicator (not shown) of the adjustment knob (4) is replaced by the housing (1 ) provided housing dose window (1i) is visible. The triggering sleeve (5), trigger button (6), retaining needle (7), ejection element (8), click sleeve (9) and the spring (12) are also rotated relative to the housing (1) and the metering stop (2) , The Ausstosselementanschlag (8a) of the Ausstosselements (8) comes out of abutment with the arranged on the inner surface of the Dosierstopps (2) Dosierstoppanschlagsfläche (2h). The Ausstosselementanschlagkerbe (8b) of Ausstosselementanschlags (8a) comes to lie in the axial alignment with Dosierstoppführungsrippe (Fig. 8a, 2j) of Dosierstopps (2). The length of the dosing stop guide rib (Figures 8a, 2j) corresponds to the dose to be administered. Further, as shown in FIG. 5b, by the relative rotation between the trigger button 6 and the metering stop 2, the trigger button edge 6e of the trigger button guide tab 6d of the release button 6 is out of abutting contact with the metering stop edge 2f of FIG wide dosing stopper rib (2g) of dosing stop (2). Furthermore, the trigger button guide tab groove (6e) of the release button (6) comes to lie in the axial alignment with the narrow dosage stop rib (2g) of the metering stop (2) corresponding to the set dose.

In the Fig. 6a is a longitudinal sectional view of a proximal part of the injection device of Fig. 1 in the first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and triggered in one dose Position shown, wherein the longitudinal sectional view of the drawn in Fig. 2e section line B-B corresponds. The user presses the trigger button (6) by means of, for example, a thumb relative to the housing (1) in the distal direction. In this case, the Auslösehülsenschnapparm (5d) reaches the trigger sleeve (5) in the proximal Auslösöseausausnehmung (6b) of the release button (6). Furthermore, the trigger button recess (6f) of the release button (6) passes over the release sleeve holding arm (5g) of the release sleeve (5b), in particular the two release button recesses (6f) of the release button (6) pass over the two release sleeve retention arms (5g) of the release sleeve (5), such that the Auslösehülsenhaltearm (5g), in particular the two Aushösehülsenhaltearme (5g) of the release sleeve (5) out of engagement with the retaining needle groove (7b), in particular the two retaining needle grooves (7b) of the retaining needle (7) arrive. As shown in Fig. 6c, the force applied to the spring (12) acting holding needle (7) relative to the housing (1) moves in the distal direction until the retaining needle stop (7a) of the holding needle (7) in abutting contact the click sleeve inner surface (9c) of the click sleeve (9) passes. In particular, an acoustic noise is generated, which indicates that the injection process has begun. As shown in Fig. 6b, the trigger button guide tab groove (6e) of the trigger button (6) slides along the narrow dosing stop rib (2g) of the dosing stop (2) corresponding to the set dose. The trigger button guide tab (6d) of the release button (6) is guided along the two release sleeve ribs (5c) of the release sleeve (5).

In Fig. 7a is a longitudinal sectional view of a proximal part of the injection device of Fig. 1 in a second state, in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is released, and the click sleeve (9) of the ejection element (8) is releasable and is mounted axially movable relative to the ejection element (8), wherein the longitudinal sectional view of the drawn in Fig. 2d section line A-A corresponds. During the distribution of the set dose moves due to the spring force of the prestressed spring (12) the ejection element (8), the click sleeve (9) and the retaining needle (7) axially relative to the housing (1) and the metering stop (2) , In this case, the first (11a) and the second plug (11d) are pushed in the distal direction. The first plug (11 b) can squeeze out the fluid product via the injection needle (not shown) attached to the carpule holder (10). Due to the axial relative movement of the click sleeve (9) engaged with the ejection element (8), the elastically prestressed click sleeve holding element (9a), in particular the click sleeve holding arm (9a), reaches beyond the inner surface of the metering stop (2 ) provided Dosierstoppaussparung (2n), wherein the click sleeve holding member (9a), in particular the click sleeve holding arm (9a) elastically relaxed in the Dosierstoppaussparung (2n) of Dosierstopps (2). The click sleeve (9) is detachable from the ejection element (8) and is mounted axially movable relative to the ejection element (8). Further, as shown in Fig. 8a and Fig. 8b, by the axial relative movement of the ejection member (8) to the metering stop (2), the ejection element stopper (8a) of the ejection member (8) moves in the distal direction Ejection stopper notch (8b) of the ejection member (8a) along the set dose corresponding dosing stop guide rib (2j, 2j, 2j) slides until the ejection element stopper (8a) of the ejection member (8) is in abutting contact with the dose stopper corresponding to the set dose (2l, 2l, 2l) of Dosierstopptreppenglied (2k) of Dosierstopps (2) passes. In this example, the user has set and distributed a medium dose. In the second state of the injection device, wherein the ejection element (8) and the click sleeve (9) of the Dosierstopp (2), in particular the Ausstosselementanschlag (8a) of the Ausstosselements (8) except stop contact of Dosierstoppanschlagsfläche (2h) of Dosierstopps (2) and wherein the click sleeve (9) is detachable from the ejection element (8) and axially movable relative to the ejection element such that the click sleeve is engageable in abutting contact with the ejection element, the ejection stop (8a) of the ejection element (8) be in abutting contact with the dosing stop stop (2l, 2l, 2l) of the dosing stop (2) corresponding to the set dose or alternatively be reachable in stop contact. After dispensing a dose and before dispensing a dose, as shown in Fig. 8a, the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding members (9a) or the two kick Sleeve holding arms (9a) on the corresponding set metering stop guide rib (2j, 2j, 2j), for example, on the metered stop guide rib (2j) of the metering stop (2) corresponding to the middle dose. Thereby, the click sleeve holding element (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding elements (9a) or the two click sleeve holding arms (9a) can engage with the click sleeve counter element (8d) or the ejection element recess (9a). 8d), in particular in engagement with the two click sleeve counter elements (8d) or the two Ausstosselementaussparungen (8d) are held. Only after the release of the set dose, for example the medium dose, as shown in Fig. 8b, the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding elements (9a) or the two Click sleeve holding arms (9a) disengage from the click sleeve counter element (8d) or the ejection element recess (8d), in particular out of engagement with the two click sleeve counter elements (8d) or the two ejection element recesses (8d), the click sleeve holding element (8) 9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding elements (9a) or the two click sleeve holding arms (9a) in the Dosierstoppaussparung (2n) corresponding to the set dose, for example in the medium dose, in particular the dosing stop gaps (2n) corresponding to the set dose protrude or snap. Alternatively, during the dispensing of the set dose, the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding members (9a) or the two click sleeve holding arms (9a) may be disengaged from the click sleeve counter member (9a). 8d) or the Ausstosselementaussparung (8d), in particular out of engagement with the two click sleeve counter elements (8d) or the two Ausstosselementaussparungen (8d), wherein the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two Click sleeve holding members (9a) or the two click sleeve holding arms (9a) in the dose corresponding to the dose set, for example, in the middle dose corresponding Dosierstoppaussparung (2n), or in particular in the set dose corresponding Dosierstoppaussparungen (2n) protrude or snap. The metering stop recess (2n), in particular the plurality of metering stop recesses (2n) of the metering stop (2) are relative to the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular to the two click sleeve holding members (9a) or arranged the two click sleeve holding arms (9a) that after the release of the set dose or during the distribution of the set dose, the click sleeve holding member (9a) or the click sleeve holding arm (9a), in particular the two click sleeve holding elements (9a) or the two click sleeve holding arms (9a) protrude or snap into the metering stop recess (2n) corresponding to the set dose, in particular into the metering stop gaps (2n) corresponding to the set dose.

In the Fig. 7b is a longitudinal sectional view of a proximal part of the injection device of Fig. 1 in the second state is shown, in which the multi-part piston rod (8, 9) is released from the Dosierstopp (2), and the click sleeve (9) is detachable from the ejection element (8) and is axially movable relative to the ejection element (8), such that the click sleeve is achievable in abutting contact with the ejection element, and the click sleeve outer surface (9d) of the click sleeve (9) is in abutting contact with the ejection element inner surface (8f) of the ejection element (8), the longitudinal sectional view corresponding to the section line A-A drawn in FIG. 2d. After the release of the set dose or during the distribution of the set dose, the click sleeve (9) of the ejection element (8) is releasable and axially movable relative to the ejection element (8) until the click sleeve (9) in abutting contact with the ejection element (8). The click sleeve (9) acted upon by the force of the spring (12) is moved in the distal direction relative to the housing (1) until the click sleeve outer surface (9d) of the click sleeve (9) is in abutting contact with the ejection element inner surface (8f) of the ejection element (8) passes. In this case, in particular, an acoustic noise is generated, which indicates that the injection process, in particular the discharge has ended.

FIG. 9 shows an exploded view of a second embodiment of an injection device according to the invention. The injection device differs from the injection device of the first embodiment substantially only with regard to the configuration and with respect to the interaction of the housing (1), the sliding sleeve (3), the carpule holder (10) and the carpule (11). wherein the carpule (11) is formed as a single-chamber carpule (11), which comprises only one chamber with a fluid product to be administered. The injection device further comprises a holding element (13), wherein the carpule (11) by means of holding element (13) on or in the carpule holder (10) can be kept free of play by the carpule (11) in the carpule holder (10) the distal side is held in axial stop contact and on the proximal side by means of the holding element (13). In this way, manufacturing and assembly tolerances can be compensated. The housing (1) may preferably have a housing guide bar (6j) which may be engaged with a carpule holder guide groove (not shown) disposed on the carpule holder (10). Furthermore, the housing (1) may have a housing web (1k), preferably a plurality of housing webs (1k). The carpule holder (10) comprises a carpule holder housing (10g), in which a recess (10f) for receiving a projection (13a) and a cam (13b) of the holding element (13) is arranged. The holding element (13) is elastically deformable. The holding element (13) comprises a spring element (13c) on which the projection (13a) and a clamping element (13d) are provided. The holding element (13) has a ring element (13e), which comprises a first spring seat (13f), a second spring seat (13g), a plurality of brackets (13h) and a plurality of connecting webs (13i), wherein the first spring seat (13f) over the a plurality of brackets (13h) and via the plurality of connecting webs (13i) with the second spring seat (13g) is connected. In a position in which the carpule (11) in the carpule holder (10) is not received, the holding element (13) in the carpule holder (10) is inserted. The projection (13a) of the holding element (13) projects into the recess (8c) of the carpule holder housing (8d) of the carpule holder (10). The cam (13b) of the holding element (13) is radially elastically biased on the inner surface of the shell of the carpule holder (10). The holding element (13) is mounted elastically relaxed in the axial direction in the carpule holder (10). The brackets (13h) are connected to one another via connecting webs (13t) and are fastened via connecting webs (13i) to the first (9f) or to the second spring seat (13g). The holding element (13) is inserted into the carpule holder (10) such that a carpule (11) can be inserted into the carpule holder (10), in particular into the carpule holder housing (10g) of the carpule holder (10). To the injection device in a first state in which the multi-part piston rod (8, 9) with the Dosierstopp (2) is detachably connected, and in an initial position, in which the injection device is delivered, according to Fig. 10a and according to Fig. 10b bring the carpule (11) through a proximal opening of the carpule holder housing (10g) of the carpule holder (10) in the carpule holder (10) pushed. The distal end of the carpule (11) may come into axial abutting contact with the distal end of the carpule holder housing (10g) of the carpule holder (10). The holding element (13) is arranged in an annular gap between the carpule holder (10) and the carpule (11). The clamping element (13d) of the spring element (13c) of the holding element (13) projects in the proximal direction over a proximal carpule edge (11f) of the carpule (11). To keep the carpule (11) free of play in the carpule holder (10), an axial force in the distal direction on the second spring seat (13g) of the holding element (13) act such that the holding element (13) elastically biased and relative to the carpule holder housing (10g) of the carpule holder (10) is displaced in the axial direction. The projection (13a) of the holding element (9) thereby comes out of engagement with the recess (10f) of the carpule holder (10), wherein the cam (13b) of the holding element (13) in engagement with the recess (13c) of the carpule holder (10 ) Comes. The spring element (13c) of the holding element (13) is thereby biased radially inwards so that the clamping element (13d) of the holding element (13) holds or engages around the proximal carpule edge (11f) of the carpule (11). The carpule (11) is supported at the distal end on or in the carpule holder (10) and at the proximal end on the holding element (13), in particular on the clamping element (13d) of the holding element (13) without play. The carpule holder (10) used with the carpule (11) can now be axially fixedly connected to the housing (1) of the injection device. A sliding sleeve (3) is already arranged in the housing (1) in a proximal position. The sliding sleeve (3) is arranged axially fixed relative to the housing (1). The housing guide bar (1j) of the housing (1) is engaged with a carpule holder guide groove (not shown) of the cartridge holder (10). The carpule holder (10) can be glued or welded to the housing (1) of the injection device. There may also be other fasteners, for example with latching or positive fastening means between the carpule holder (10) and the housing (1) may be provided. Preferably, for better attachment of the carpule holder (10) on or in the housing (1) of the injection device between the axially extending housing webs (1k) of the housing (1) of the injection device glue or an alternative attachment means are applied or inserted , Alternatively, the carpule holder (10) may comprise a carpule holder web, preferably a plurality of carpule holder webs extending in the axial direction, between which adhesive or an alternative attachment means is applied or inserted. Alternatively, carpule holder webs can be provided on the carpule holder (10) and housing webs (6e) on the housing (1) of the injection device.

11a shows a perspective view of a third embodiment of an injection device according to the invention in a first state, in which a multi-part piston rod (8, 9) is detachably connected to a metering stop (not shown), and in a starting position in which the injection device is delivered, wherein only the multi-part piston rod (8, 9), a holding needle (7), a spring (12) and a holding sleeve (14) can be seen. 11b shows a partial view as a longitudinal section of the injection device according to FIG. 11a, wherein likewise only the multi-part piston rod (8, 9), the retaining needle (7), the spring (12) and the retaining sleeve (FIG. 14) are visible. The injection device differs from the injection device of the first embodiment substantially only with regard to the configuration and with respect to the interaction of the ejection element (8), the click sleeve (9), the Dosierstopps (not shown) and the retaining sleeve ( 14). The ejection member (8) has an ejection element guide groove (8g) and an ejection element guide surface (8h) in place of the click sleeve retaining counterpart member (8d), particularly the ejection element recess (8d). The click sleeve (9) has a click sleeve guide member (9f), a click sleeve guide surface (9g) and a click sleeve groove (not shown) instead of the click sleeve holding member (9d), particularly the click sleeve holding arm (9a). on. The metering stop (not shown) does not include metering stop recesses (2n) and metering stop guide ribs (2j, 2j, 2j). Furthermore, the injection device comprises a holding sleeve (14) which has a holding sleeve rib (14a). On the click sleeve guide member (9f) of the click sleeve (9), the click sleeve guide surface (9g) is arranged. The ejection element guide surface (8d) of the ejection member (8) and the click sleeve guide surface (9g) of the click sleeve (9) are formed so as to form a cooperative guide groove. The ejection element guide surface (8d) and the click sleeve guide surface (9g) may be formed as cooperating screw portion shaped guide surfaces. The kick sleeve (9) is rotatably arranged relative to the ejection element (8). The cooperating guide slot of the ejection element (8) and the click sleeve (9), in particular the ejection element guide surface (8h) and the click sleeve guide surface (9g) are formed such that a relative rotational movement between the ejection element (8) and the Click element (9) can be effected. The ejection element guide groove (8g) of the ejection member (8) is formed so as to receive the click sleeve guide member (9f) of the click sleeve (9). The ejection element guide groove (8g) is arranged in the circumferential direction of the ejection member (8) offset from the ejection element guide surface (8d). The retaining sleeve (14) is arranged axially movable on the proximal end of the ejection element (8) and the click sleeve (9). The retainer sleeve rib (14a) of the retainer sleeve (14) is configured to cooperate with the ejection element stop notch (8b) of the ejection element stop (8a) and with the click sleeve groove (not shown) disposed on the proximal end. In the first state, in which the multi-part piston rod (8, 9) is releasably connected to the dosing stop (2), and in the starting position, in which the injection device is delivered, the ejection element guide surface (8h) of the ejection element (8) in Stop contact with the click sleeve guide surface (9g) of the click sleeve (9). The click sleeve guide member (9f) of the click sleeve (9) is disengaged from the ejection element guide recess (8g) of the ejection member (8). The retaining sleeve rib (14a) is engaged with the ejection element stop notch (8b) of the ejection member (8) and engaged with the click sleeve groove (not shown) of the click sleeve (9). The distal end of the retaining sleeve rib (14a) projects beyond the distal end of the ejection stop (8a). The holding needle (7) is acted upon by a force acting in the distal direction of a spring. The retaining needle stop (7a) of the retaining needle (7) is of click sleeve inner surface (9c) of the click sleeve (9) and the click sleeve outer surface (9d) of the click sleeve (9) is of the inner surface of the ejection element (9). 8f) of the ejection element (9) spaced.

12 is a partial view as a longitudinal section of the injection device of the third embodiment of an injection device according to the invention in the first state, in which the multi-part piston rod (8, 9) with the metering stop (not shown) is detachably connected, and in a dose triggered position. The user presses a trigger button (not shown) by, for example, a thumb relative to a housing (not shown) of the injection device in the distal direction. In this case, the holding needle (7) can be released by a release sleeve (not visible) of the injection device. The holding needle (7) acted upon by the force of the spring (12) can be moved relative to the housing (not shown) in the distal direction until the holding needle stop (7a) of the holding needle (7) is in abutting contact with the click Sleeve inner surface (9c) of the click sleeve (9) passes. The force of the spring (12) acts on the click sleeve (9). A relative rotational movement between the click element (9) and the ejection element (8) by the engagement between the retaining sleeve rib (14 a) of the holding sleeve (14) and the Ausstosselementanschlagkerbe (8 b) of the ejection element (8) and through the Engagement between the retaining sleeve rib (14 a) of the holding sleeve (14) and click-sleeve groove (not visible) of the click sleeve (9) prevented.

In Fig. 13a is a perspective view of the third embodiment of an inventive injection device is shown in a second state in which the multi-part piston rod (8, 9) of the dosing stop (not shown) is released, and the click sleeve (9) is detachable from the ejection element (8) and is axially movable relative to the ejection element (8), such that the click sleeve is achievable in abutting contact with the ejection element, and the click sleeve outer surface (9d) of Click sleeve (9) in abutting contact with the Ausstosselementinnenfläche (8f) of the Ausstosselements (8), wherein only the multi-part piston rod (8, 9), the retaining needle (7), the spring (12) and the holding sleeve (14) are shown. FIG. 13b shows a partial view as a longitudinal section of the injection device according to FIG. 13a, wherein only the multi-part piston rod (8, 9), the holding needle (7), the spring (12) and the holding sleeve (14) are shown. are shown. During the dispensing of the set dose, due to the spring force of the biased spring (12), the ejection element (8), the click sleeve (9) and the retaining needle (7) move axially relative to the housing (not shown) and the dosing stop (not visible). By the axial relative movement of the ejection element (8) to the dosing stop (not shown), the ejection element stop (8a) of the ejection element (81) moves in the distal direction until the ejection element stopper (8a) of the ejection element (8) moves into Stop contact with one of the set dose corresponding Dosierstoppanschlag (not visible) of a Dosierstopptreppenglieds (not visible) of Dosierstopps (not visible) passes. In this case, the holding sleeve (14) shifts axially relative to the ejection element (8) in the proximal direction until the distal end of the retaining sleeve rib (14a) is arranged flush with the distal end of the Ausstosselementanschlags (8a). The retaining sleeve rib (14a) disengages from the click-sleeve groove (not shown). Due to the force acting on the click sleeve (9) of the spring (12) and the cooperating guide slot between the click sleeve (9) and the ejection element (8), the click sleeve (9) relative Turn to the ejection element (8). The click sleeve guide surface (9g) of the click sleeve (9) moves relative to the ejection element guide surface (8h) of the ejection member (8) until the click sleeve guide member (9f) passes over the ejection element guide groove (8g). The force of the spring (12) then causes the click sleeve guide member (9f) to be moved in the distal direction into the ejection element guide recess (8g). As shown in FIG. 13b, the click sleeve (9) acted upon by the force of the spring (12) is moved in the distal direction relative to the housing (not shown) until the click sleeve outer surface (9d ') moves. ) of the click sleeve (91) comes into abutting contact with the ejection element inner surface (8f) of the ejection element (8). In particular, an acoustic noise is generated which indicates that the injection process has ended.

reference numeral

[0043] <Tb> 1; 1 <SEP> housing <Tb> 1a <September> housing recess <1b> <SEP> proximal housing stop <tb> 1c <SEP> distal housing stopper <Tb> 1d <September> housing edge <Tb> 1e <September> housing internal thread <Tb> 1f <September> housing window <Tb> 1g <September> housing groove <Tb> 1h <September> housing opening <Tb> 1 i <September> Housing dose window <Tb> 1 j <September> Housing guide web <Tb> 1k <September> housing web <Tb> 2 <September> Modulates <Tb> 2 <September> Dosierstoppnocke <Tb> 2b <September> Dosierstoppkante <Tb> 2c <September> Dosierstopprippe <Tb> 2d <September> Dosierstoppringnut <Tb> 2e <September> Dosierstoppsperranschlag <Tb> 2f <September> Dosierstoppkante <tb> 2g <SEP> wide metering stopper rib <tb> 2g <SEP> Narrow Dosierstoppsperrrippe <Tb> 2h <September> Dosierstoppanschlagfläche <Tb> 2i <September> Dosierstoppausnehmung <tb> 2j <SEP> Dosing stop guide rib for a small dose <tb> 2j <SEP> Dosing stop guide rib for a medium dose <tb> 2j <SEP> Dosing stop guide rib for a large dose <Tb> 2k <September> Dosierstopptreppenglied <tb> 2l <SEP> Dose stop for a small dose <tb> 2l <SEP> Dose stop for a medium dose <tb> 2l <SEP> Dose stop for a large dose <tb> 2m <SEP> first dosing stop shoulder <tb> 2m <SEP> second dosing stop shoulder <Tb> 2n <September> Dosierstoppaussparung <Tb> 2o <September> Dosierstoppauflagefläche <Tb> 2p <September> Dosierstoppöffnung <Tb> 3 <September> sliding sleeve <Tb> 3 <September> sliding sleeve rib <Tb> 3b <September> sliding sleeve edge <Tb> 3c <September> Schiebehülsenschnapparm <Tb> 3d <September> sliding sleeve lever <tb> 3d <SEP> Sliding sleeve cam <tb> 3d <SEP> Sliding sleeve locking wing <Tb> 4 <September> adjusting <Tb> 4 <September> Einstellhülsenvorsprung <Tb> 4b <September> Einstellhülsenringkante <Tb> 4c <September> Einstellhülsennut <Tb> 4d <September> Einstellhülsenwulst <Tb> 4e <September> Einstellhülsenanschlag <Tb> 4f <September> Einstellhülsenrippen <Tb> 5 <September> trigger sleeve <Tb> 5 <September> trigger sleeve cam <Tb> 5b <September> trigger sleeve stop <Tb> 5c <September> trigger sleeve rib <Tb> 5d <September> Auslösehülsenschnapparm <Tb> 5e <September> Auslösehülsenabstützfläche <Tb> 5f <September> Auslösehülsennut <Tb> 5g <September> Auslösehülsenhaltearm <Tb> 6 <September> release button <Tb> 6 <September> release button rib <tb> 6b <SEP> distal release button recess <tb> 6b <SEP> proximal release button recess <Tb> 6c <September> release button edge <Tb> 6d <September> release button guide plate <Tb> 6e <September> Auslöseknopfführungslaschennut <Tb> 6f <September> release button recess <Tb> 7; 7 <SEP> holding needle <Tb> 7; 7a <SEP> Holding pin stop <Tb> 7b <September> Haltenadelnut <Tb> 8; 8 <SEP> Eject element <Tb> 8a; 8a <SEP> Ejection stopper <Tb> 8b; 8b <SEP> Eject element stop notch <Tb> 8c <September> discharge element shoulder <Tb> 8d <September> Click-sleeve holding counter-member <Tb> 8e <September> Ausstosselementverdrehsicherungsfläche <Tb> 8f; 8f <September> output member inner surface <Tb> 8g <September> discharge element guide recess <Tb> 8h <September> output member guide surface <Tb> 9; 9 <SEP> click sleeve <Tb> 9 <September> Click-sleeve holding member <Tb> 9b <September> Click-sleeve Enver-rotation surface <Tb> 9c; 9c <SEP> click sleeve inner surface <Tb> 9d; 9d <SEP> click-sleeve outer surface <Tb> 9e <September> Click-sleeve shoulder <Tb> 9f <September> Click-sleeve guide member <Tb> 9g <September> Click-sleeve guide surface <Tb> 10; 10 <SEP> Carpal holder <Tb> 10 <September> Karpulenhalteraussengewinde <Tb> 10b <September> Abmischanzeigeeinrichtung <Tb> 10c <September> Karpulenhalterrastarm <Tb> 10d <September> needle connecting element <Tb> 10e <September> Karpulenhalterkante <Tb> 10f <September> recess <Tb> 10g <September> Karpulenhaltergehäuse <Tb> 11; 11 <SEP> carpule <tb> 11a <SEP> first chamber <tb> 11b <SEP> first stopper <tb> 11c <SEP> second chamber <tb> 11d <SEP> second stopper <Tb> 11e <September> Bypass <tb> 11f <SEP> proximal carpule margin <Tb> 12; 12 <SEP> Spring <Tb> 13 <September> holding element <Tb> 13 <September> Lead <Tb> 13b <September> cam <Tb> 13c <September> spring element <Tb> 13d <September> clamping element <Tb> 13e <September> ring member <tb> 13f <SEP> first spring seat <tb> 13g <SEP> second spring seat <Tb> 13h <September> Ironing <Tb> 13i <September> connecting web <Tb> 14 <September> holding sleeve <Tb> 14 <September> holding sleeve rib

Claims (15)

1. Injection device for the metering and distribution of a dose of a fluid product with: - A housing (1; 1) with several stops or with the housing (1; 1) firmly connected Dosierstopp (2) with multiple stops (2l, 2l, 2l), in particular with several Dosierstoppanschlägen (2l, 2l, 2l), One of the housing (1, 1) or one of the with the housing (1, 1) fixedly connected Dosierstopp (2) detachable multi-part piston rod (8, 9, 8, 9) comprising a click sleeve ( 9, 9) and an ejection element (8, 8), A spring (12; 12) mounted in the housing (1; 1) or in a metering stop (2) fixedly connected to the housing (1; 1), which spring supports at least part of the piston rod (8,9; , 9) applied with a force, - wherein the ejection element (8; 8) for adjusting a dose to be administered relative to the housing (1; 1) or relative to the with the housing (1; 1) firmly connected dosing stop (2) is rotatable, and Wherein the ejection element (8, 8) has an ejection element stop (8a, 8a) which, in a second state of the injection device, in which the multi-part piston rod (8, 9, 8, 9) is separated from the housing (1; 1) or is released from the metering stop (2) fixedly connected to the housing (1, 1), in abutting contact with one of the plurality of stops (2l, 2l, 2l) of the housing (1; ) Or the metering stop (2) fixedly connected to the housing, in particular with one of the several metering stop stops (2l, 2l, 2l), or can be achieved, characterized in that the injection device is designed such that in a first state of the injection device, in which the multi-part piston rod (8, 9, 8, 9) with the housing (1, 1) or with the housing (1, 1) fixedly connected Dosierstopp (2) releasably connected is, the click sleeve (9; 9) relative to the ejection element (8; 8) rotatably and / or axially fixed, and that in the second state of the injection device, the click sleeve (9; 9) of is detachable relative to the ejection element (8; 8), such that the click sleeve (9; 9) can be brought into abutting contact with the ejection element (8; 8) is. 2. Injection device according to claim 1, characterized in that in the second state of the injection device the click sleeve (9, 9) is axially movable relative to the ejection element (8, 8) until the click sleeve (9, 9 ) Is in abutting contact with the ejection element (8; 8) and generates an audible signal to indicate that the dose distribution has been completed. 3. Injection device according to claim 1 or 2, characterized in that on the housing (1; 1) or on the with the housing (1; 1) fixedly connected dosing stop (2) provided for several stops (2l, 2l , 2l), in particular the plurality of metering stop stops (2l, 2l, 2l) are formed in a staircase, wherein by a rotational movement of the ejection element (8; 8) relative to the housing (1; 1) or relative to the metering stop (2) fixedly connected to the housing (1; 1), a step is set as a stop to set the respective dose to be administered. 4. Injection device according to one of the preceding claims, characterized in that the injection device comprises a holding needle (7; 7), wherein the holding needle (7; 7) of the ejection element (8; 8) is received and the holding needle (7 7) is acted upon by the force of the spring (12; 12). 5. Injection device according to claim 4, characterized in that the holding needle (7, 7) with the force of the spring (12, 12) relative to the click sleeve (9, 9) is axially movable until the holding needle ( 7; 7) is in abutting contact with the click sleeve (9; 9) and produces an audible signal to indicate that the dose delivery begins. 6. Injection device according to one of the preceding claims, characterized in that the housing (1; 1) or with the housing (1; 1) firmly connected Dosierstopp (2) surrounds the click sleeve (9; 9). 7. Injection device according to one of the preceding claims, characterized in that the click sleeve (9) has a click sleeve holding element (9a) which in the first state of the injection device with a on the ejection element (8) arranged click sleeve holding counter-element (8d ), and in the second state of the injection device, the click sleeve holding member (9a) is disengageable with the click sleeve holding counter member (8d). 8. Injection device according to one of the preceding claims, characterized in that the housing (1; 1) or with the housing (1; 1) firmly connected Dosierstopp (2) is designed such that in the first state of the injection device, the click Sleeve holding member (9a) can be held in engagement with the click sleeve holding counterpart member (8d). 9. Injection device according to one of the preceding claims, characterized in that the housing (1; 1) or with the housing (1; 1) firmly connected Dosierstopp (2) is designed such that in the second state of the injection device Click sleeve holding member (9a) out of engagement with the click sleeve holding counter element (8d) can be brought. 10. Injection device according to claim 9, characterized in that the housing (1; 1) or the metering stop (2) firmly connected to the housing (1; 1) has a recess (2n), in particular a metering stop recess (2n), wherein the click sleeve holding member (9a) in the recess (2n), in particular in the Dosierstoppaussparung (2n) can be brought. 11. Injection device according to claim 10, characterized in that for each stop of the plurality of stops of the housing (1; 1) or the Dosierstopps (2), in particular the Dosierstoppanschlägen (2l, 2l, 2l) a corresponding Recess (2n), in particular a corresponding Dosierstoppaussparung (2n) is associated. 12. Injection device according to one of claims 1 to 6, characterized in that the click sleeve (9) and the ejection element (8) form a cooperating guide slot (8h, 9g), in particular in each case a cooperating screw portion-shaped guide surface (8h, 9g ) exhibit. 13. Injection device according to claim 11, characterized in that the guide slot (8h, 9g), in particular the two screw portion-shaped guide surfaces (8h, 9g) are formed such that a relative rotation and / or a relative axial movement between the click sleeve ( 9) and the ejection element (81) is executable. 14. An injection device according to any one of claims 12, characterized in that the injection device further comprises a holding sleeve (14) which is designed such that in the first state of the injection device relative rotation between the click sleeve (9) and the ejection element (8) is prevented. 15. Injection device according to claim 13, characterized in that in the second state of the injection device, the holding sleeve (14) is engageable in abutting contact with the set stop of the housing or fixed to the housing Dosierstopps, in particular the Dosierstoppanschlags.