CH708198A1 - System for producing a bone substitute material, comprising a container and a retaining member. - Google Patents

Abstract

A system (100) for producing a bone substitute material comprises a container (110) in the form of a cylindrical tube which receives a solid component of the bone substitute material. To facilitate the introduction of a liquid component, the system also includes a retention member (120) which is attached to one end of the container and which allows the escape of gases from the container while retaining the solid component in the container. The retaining element may be a filter. The liquid component is then filled through the other end of the container. In this case, existing air in the container can escape through the retaining element.

Description

The present invention relates to a system for producing a bone substitute material.

STATE OF THE ART

Bone replacement materials, in particular synthetic bone-graft materials, are used in various medical fields, such as dentistry, orthopedics or reconstructive surgery. Such materials are often made by mixing a solid component in particulate form, e.g. in the form of a powder or granules, mixed with at least one liquid component to a high-viscosity mass ("putty"). The solid component may be e.g. a component based on tricalcium phosphate, calcium sulfate or calcium hydroxyapatite, which may optionally be mixed with excipients such as growth factors. The liquid component is usually an endogenous fluid such as blood or a liquid product made from it, such as blood plasma or a bone marrow suspension. Frequently, the liquid component contains growth factors and / or cells.

Various methods are known for mixing the liquid component with the solid component. In the simplest case, the solid component is placed in a bowl, the liquid component is added, and the two components are stirred. Subsequently, the bone substitute material thus produced is either applied directly or placed in a dispensing device, e.g. a syringe, filled and applied with this syringe. There are also known discharge devices in which the solid component is introduced into a syringe in advance and the liquid component is added directly into the syringe. Such discharge devices are e.g. offered by Medmix Systems AG under the name G-System. However, the bone substitute material can be applied to these devices only with loss of material in places that are difficult to access.

In WO 2009/156 718 and in WO 2013/063706 A2 discharge devices for bone replacement materials are disclosed in which a ready-prepared bone substitute material is provided in a slender, cylindrical tube. The tube has a constant cross section throughout. To deliver the bone substitute material, the tube is attached to a suitable dispenser. This presses out the bone substitute material from the tube by means of a piston. The tube can be passed directly to the site of application, even if it is in a body cavity.

However, such systems are only conditionally suitable for situations in which the content of the tube before the application still a liquid component to be added. When the liquid component is filled into the single-ended tube, it is not ensured that the air, which is inevitably located in the interstices between the particles of the solid component, can escape from the tube during filling, so that the liquid component may possibly not evenly distributed in the tube. This is especially tricky if the tube has a small diameter.

PRESENTATION OF THE INVENTION

It is therefore desirable to provide a system which allows the container to be pre-filled with a solid component and which is particularly well suited for adding a liquid component directly to the solid component in the container. In particular, the system should enable uniform mixing of the solid and liquid components to take place, even with a small container diameter. The advantages of a container in the form of a tube should be preserved.

The invention proposes a system according to claim 1 for this purpose. Advantageous embodiments are specified in the dependent claims.

The invention provides a system for producing a bone substitute material, comprising: a container in the form of a cylindrical tube having a first end and a second end, the container having a substantially uniform cross-section on the inside over its entire length; and a retention member connectable to the first end of the container and allowing gases to exit the container while retaining solids in the container.

With this system, the liquid component is filled through the second end of the tube opposite the first end with the filter. In this way, it is ensured that during the filling of the liquid component, air can escape from the container while the solid component is retained in the container. The air contained in the container can escape completely even if the tube has a very small diameter. This makes it possible to continue to use a thin, long tube for receiving the bone substitute material, with all the associated benefits. Here are in particular the simple production, the great flexibility in terms of the dimensions of the tube and the suitability for application to difficult to reach places to call. The system is particularly suitable for filling with the liquid component directly in the operating room.

The container has on the inside over its entire length on a substantially constant cross-section. Thus, when the cross section is circular, the container has a substantially constant inner diameter. This also includes containers whose cross-section or inner diameter changes slightly over the length of the container, as long as the changes are not abrupt and sufficiently small to be able to guide a piston continuously inside the container wall for discharging the bone substitute material.

The container preferably has a length which is at least five times, preferably at least ten times, more preferably at least 20 times the inner diameter. In absolute terms, the length of the container is preferably at least 100 mm, preferably about 150-300 mm. The inner diameter of the container is preferably about 3-10 mm, more preferably about 5-7 mm. The wall thickness of the container is preferably about 0.5-1 mm. The container may e.g. made of polypropylene (PP), polyamide (PA), polyetheretherketone (PEEK) or polycarbonate (PC).

Examples of suitable containers are disclosed in particular in the already mentioned WO 2013/063 706 A2, the content of which is incorporated herein by reference in this description.

The retaining element is preferably a filter. This can e.g. a porous material, e.g. a sintered material, or a porous membrane, e.g. a porous plastic membrane, or a mesh of plastic, mineral or metallic filaments, e.g. in the form of a sieve or in the form of a disordered tangle. The retaining element may comprise a valve instead of a filter or in addition to a filter. The valve can be designed so that it allows the passage of gases in one direction only, namely out of the container (one-way valve).

Preferably, the system further comprises a holding element which is adapted to hold the retaining element releasably and sealingly at the first end of the container. The retaining element may be fixedly connected to the retaining element, or the retaining element and the retaining element may be detachable, separate parts.

In a particularly simple embodiment, the retaining element is a filter in the form of a flat disc, which can be placed on a peripheral, frontal boundary surface of the first end of the container. The retaining element is then designed to press the filter onto the boundary surface. However, other embodiments of the filter are conceivable, e.g. an embodiment in the form of a porous plug, which is insertable in the first end of the container in this. In such cases, a separate holding element may also be omitted.

At least at the first end of the container, a first connection structure is preferably formed on the outside. The retaining element then preferably has a second connecting structure, which is complementary to the first connecting structure, and the retaining element is releasably fixable by means of the second connecting structure at the first end of the container. The first connection structure is preferably an external thread, and the second connection structure is correspondingly preferably an internal thread. However, it is also conceivable to use other types of connection structures, e.g. Provide pins, webs and / or grooves for a bayonet connection.

Preferably, a first connection structure is formed at both ends of the container in each case on the outside, and the first connection structures are similar at both ends and preferably substantially identical. This makes it possible to attach the container either with one of its two ends to a discharge device, and it ensures a particularly intuitive handling. If external threads are present, they preferably have identical parameters at both ends of the container, in particular number of threads, flank shape, outer and core diameter and pitch. In addition, the threads are preferably also identical in every other respect (ie in particular also have the same length). In this way, it immediately becomes obvious to the user that the orientation of the container does not matter at all. This eases the work for the user (usually a surgeon) and reduces the risk of operating errors. This can be an important factor, especially in the rush of an operating room. The same applies to other types of connection structures.

If the container is formed identically at both ends, it may be advantageous to provide in the delivery state at both ends of the container in each case a similar retaining element and optionally a similar retaining element. In this way, it does not matter in handling at which end of the container is opened to fill the solid and / or liquid component in the container.

The holding member may be formed as a removable cap for the first end of the container, with a jacket wall surrounding the container at the first end, and an end wall. The cap preferably has at least one opening, which allows the passage of gases. The opening is preferably arranged in the end wall of the cap. The cap preferably has an outer circumference which is not greater than twice or three times the outer circumference of the container at its first end.

In an alternative embodiment, the holding element forms a stand or base. This is designed to stably rest on a flat surface (e.g., a countertop) and is adapted to receive the first end of the container to hold the container in a vertical orientation. The stand preferably has a diameter which is at least five times, more preferably at least ten times the outer diameter of the container in order to ensure sufficient stability. In absolute terms, the stand preferably has a diameter of at least 30 mm, preferably at least 50 mm. In practice, the diameter will usually not exceed 100 mm.

In yet another embodiment, the holding element forms an intermediate piece for connection to a vacuum source. When the adapter is connected to the first end of the container and a vacuum is applied to the adapter, the liquid component may be aspirated through the second end of the container. The retaining element prevents particles of the solid component from entering the vacuum source.

The system may further comprise a funnel connectable to the second end of the container for filling the solid component and / or the liquid component into the container.

The container may be prefilled with a solid or semi-solid component of a bone substitute material. The system is also suitable for the production of other, in particular implantable, materials such as bone cements, etc. Solid components include: powder, granules, splinters and other particulate components. Semisolid components include suspensions, mixtures of liquid and solid materials and other porous components.

The system may comprise a filling device, in particular in the form of a syringe or the aforementioned funnel, for filling the liquid component into the container. The filling device is then connectable to the second end of the container. For this purpose, it may have a fastening structure that is complementary to at least one of the connecting structures of the container. For example, if the interconnect structures are e.g. is external thread, the attachment structure has an internal thread. On the other hand, if the connection structures are e.g. is about elements of a bayonet connection such as bayonet pins, the attachment structure has a corresponding complementary bayonet mount.

The system may further comprise a discharge device, e.g. like a pistol dispenser. The discharge device may include: a base body adapted to receive the container; a relative to the base body by hand pivotable actuating lever; and a relative to the main body displaceable piston rod which is dimensioned such that it is insertable into the container to squeeze a material from the container, and which is coupled to the actuating lever such that actuation of the actuating lever advances the piston rod in a distal feed direction causes.

On the main body then preferably a fastening structure is present, which is complementary to at least one of the connecting structures of the container. The attachment structure may in particular be formed on an adapter, which is formed separately from the base body and is preferably removably attached to the base body.

An example of a suitable discharge device is disclosed in particular in the already mentioned WO 2013/063 706 A2, the content of which is incorporated herein by reference into this description.

The container preferably contains no displaceable piston before filling with the liquid component. The piston is then preferably provided by the discharge device. For this purpose, the piston rod may have at its distal end a releasably or permanently attached piston. However, if the container already contains a piston prior to filling with the liquid component, it may constitute the retaining element and for this purpose e.g. be porous.

The container may not only be a straight tube, but may also be in the form of a curved or flexible tube. This makes it possible to reach even hard to reach places. A flexible container may e.g. be made of a flexible polyethylene (PE), PP or polytetrafluoroethylene (PTFE). Accordingly, the piston rod of the dispenser can also be made flexible.

The invention also provides a method of making a bone replacement material. The method comprises the following steps: Providing a container in the form of a cylindrical tube, having a first end and a second end, the container having a substantially uniform cross-sectional inside over its entire length, wherein the container is filled with a solid or semi-solid component of the bone substitute material and wherein the a retention member is attached to the first end of the container, the retention member allowing gases to exit the container while retaining solids in the container; and Filling a liquid component of the bone substitute material through the second end of the container.

The foregoing considerations of the system of the present invention also apply to the method of the present invention. In particular, the method can be carried out with a system of the type described above. In particular, the method can be performed directly in an operating room during an operation.

BRIEF DESCRIPTION OF THE DRAWINGS

Preferred embodiments of the invention are described below with reference to the drawings, which are merely illustrative and not restrictive interpreted. In the drawings show: <Tb> FIG. 1 <SEP> a system for producing a bone substitute material according to a first embodiment in side view; <Tb> FIG. 2 <SEP> is a detail view of FIG. 1; <Tb> FIG. 3 <SEP> the system of Figure 1 in assembled state in side view. <Tb> FIG. FIG. 4 shows the system of FIG. 1 in an assembled state in a central longitudinal section; FIG. <Tb> FIG. 5 <SEP> is a detail view of FIG. 4; <Tb> FIG. 6 shows a system for producing a bone substitute material according to a second exemplary embodiment in side view; <Tb> FIG. 7 <SEP> is a detail view of FIG. 6; <Tb> FIG. FIG. 8 shows the system of FIG. 6 in an assembled state in side view; FIG. <Tb> FIG. FIG. 9 shows the system of FIG. 6 in an assembled state in a central longitudinal section; FIG. <Tb> FIG. 10 shows a system for producing a bone substitute material according to a third exemplary embodiment in a central longitudinal section; and <Tb> FIG. 11 <SEP> is a detail view of FIG. 10; <Tb> FIG. 12 <SEP> a discharge device with connected pipe in a central longitudinal section.

DESCRIPTION OF PREFERRED EMBODIMENTS

In FIGS. 1-5, a first embodiment of a system for producing a bone substitute material is shown by way of example. The system 100 comprises a container in the form of a cylindrical tube 110, a retaining element in the form of a filter 120 and a retaining element in the form of a cap 130.

The tube 110 has on the inside a circular cylindrical cross-section, which does not change substantially over its entire length and which in particular does not taper at the ends of the tube. At both ends, the tube has identical external threads 111, 112. No separate displaceable piston is accommodated in the tube.

The filter 120 has the shape of a flat cylindrical disc whose diameter substantially corresponds to the outer diameter of the tube 110.

The cap 130 has a cylindrical shell wall and an end wall. In the casing wall, an internal thread 131 is formed on the inside, which is complementary to the external threads 111, 112. In the end wall a passage opening 132 is formed.

The filter 120 rests on an end face of the tube 110 and is fixed there by the end wall of the cap 130 when the internal thread 131 is engaged with the external thread 111 of the tube 110. Through the filter 120 and through-hole 132, air can escape from the tube 110 while retaining particles in the tube. Optionally, the filter 120 may be configured to retain a liquid component as well.

The tube 110 is preferably prefilled with a solid or semi-solid, preferably particulate component 113 of a bone substitute material, but may optionally also be filled in the operating theater with such a component. The solid component may be e.g. a granulate or powder based on porous ceramic particles, hydroxyapatite, tricalcium phosphate, calcium sulfate, demineralized bone matrix, autogenous or allogenic bone fragments, etc. The solid component can be mixed with excipients such as growth factors. The invention is not limited to any particular type of solid component.

If the tube 110 is prefilled, it is preferably closed on both sides in the delivery condition. In particular, it may be closed on both sides with identical filters 120 and caps 130, so that it does not matter in subsequent handling which end of the tube is first opened. The tube thus sealed may additionally be received in an outer packaging.

To add the liquid component to the solid component in the tube 110, the tube is opened at one end while remaining closed at the other end by the filter 120 and the cap 130. The liquid component is now filled through the open end. For this purpose, the open end can be connected to a filling device for the liquid component.

As an example of such a filling device is shown in Figures 1, 3 and 4, a syringe 200 with syringe body 210 and syringe plunger 220. In the present example, the syringe body 210 has a connection region 211 with a male luer cone and a fixed internal sleeve with which it is secured. The luer taper is inserted into the open end of the tube 110 and the tube is secured to the syringe body 210 via the threaded connection between the male thread 112 and the female thread of the locking sleeve 210.

By pressure on the syringe plunger 220, the liquid component received in the syringe 200 is now pressed into the tube 110. At the same time, the liquid component displaces the air that is in the interstices between the particles of the first component. The displaced air escapes through the filter 120 and the through-hole 132. In this way, the entire space between the particles can be filled with the liquid component, and a uniform mixing results between the solid and the liquid component.

A second embodiment of a system for producing a bone substitute material is shown in Figs. 6-9. The system 100 in turn comprises a tube 110 and a filter 120. With regard to these elements, reference is made to the first embodiment. Instead of a cap 130, the system 100 comprises a holding element in the form of a stand (base) 140. In addition, a funnel 150 is shown, which serves to fill a solid and optionally also a liquid component in the tube 110.

The stand 140 forms a receiving area for one end of the tube 110. This receiving area has, similar to the cap 130, a cylindrical shell wall and an end wall. In the jacket wall, an internal thread 141 is formed, which is complementary to the external threads III, 112. In the end wall, a passage opening 142 is formed. In the receiving area of the filter 120 is inserted so that it rests on the end wall. The receiving area is surrounded by a base portion 143, whose peripheral lower edge is arranged in a plane. With this lower edge, the stand can be placed on a flat surface, e.g. on a countertop, be turned off. The stand holds a tube 110 received in the receiving area in a vertical orientation. The tube lies on the front side on the filter 120.

Of course, a variety of modifications of the stand shown is possible without the function of the stand changes.

To fill the tube 110 with the solid component, the funnel 150 is attached to the open top of the tube. For this purpose, the funnel 150 has a fastening region with a cylindrical jacket wall, on which an internal thread 151 is formed in order to screw the funnel onto the external thread 112. The attachment area is adjoined by an upwardly widening filling area. In these, the solid component is given so that it trickles into the tube.

Subsequently or instead, a liquid component can be filled in the same way. Alternatively, the liquid component may be mixed with another type of filling device, e.g. filled with the syringe described above. In turn, air is reliably displaced from the interstices of the solid component and the air can escape through the filter 120.

A third embodiment of a system for producing a bone replacement material is shown in FIGS. 10 and 11. The system 100 again comprises a tube 110, a filter 120 and a funnel 150. With regard to these elements, reference is made to the first and second embodiments.

Instead of a cap 130 (as in the first embodiment) or a stand 140 (as in the second embodiment), the system 100 comprises »a holding element in the form of an intermediate piece 160, with the aid of which through the filter 120, a negative pressure in the interior of the tube 110 can be generated. For this purpose, the intermediate piece 160 has a cap-like region, which is constructed similarly to the cap 130 and is screwed onto the lower (first) end of the tube with the external thread 111. In particular, the cap-like region has a jacket wall with an internal thread 161 and an end wall with a central passage opening. The filter 120 is, as in the previous embodiments, on a front-side boundary surface of the tube 110. It is fixed there by the end wall of the cap-like portion of the intermediate piece 160.

At the central passage opening closes outwards, facing away from the end of the tube 110, a short pipe socket, which forms a vacuum connection 162. On the pipe socket a vacuum hose 163 is pushed, which is connected to a vacuum source. In this way, at the lower end of the tube 110, a negative pressure can be generated. As a result, air can be sucked out of the tube 110 through the filter 120, while particles in the tube 110 are retained. Optionally, the filter 120 may in turn be configured to retain a liquid component as well.

The tube 110 can be delivered pre-filled with a solid component 113, or the solid component can be filled as in the second embodiment only immediately prior to use in the tube 110. For this purpose, as in the second embodiment, at the upper (second) end of the tube 110, a funnel 150 are attached.

To add the liquid component, it is also added to the funnel, and a negative pressure is generated at the intermediate piece 160. As a result, the second component is sucked into the pipe and replaces the air that escapes from the pipe due to the negative pressure. As soon as the solid component is sufficiently permeated with the liquid component, the effect of the negative pressure is terminated, and the funnel and the intermediate piece can now be removed.

Instead of adding the liquid component to the funnel, it is also conceivable to aspirate the liquid component from another container or directly from the body of a patient. For this purpose, it is conceivable to connect the open first end of the tube with a cannula inserted into the body of a patient to aspirate a body fluid such as blood or bone marrow aspirate. In this way, the bone substitute material in turn can be very easily produced.

Of course, a variety of other possibilities are conceivable as the liquid component can be transferred under vacuum effect in the tube 110. Of course, depending on the type of vacuum source, the intermediate piece may be formed differently than in the present example.

FIG. 12 illustrates a discharge device 300 in the form of a pistol dispenser in order to discharge the mixture thus prepared and to apply it in the body. The structure and operation of the discharge device largely correspond to the discharge device disclosed in WO 2013/063706 A2, and reference is made to this document for details.

The discharge device 300 comprises a base body 310, on which a rigid handle 320 is integrally formed. An operating lever 330 is pivotally connected to the main body 310. By way of a mechanism not shown in detail, the actuating lever 330 is coupled to a piston rod 360 extending through the body 310 and having a piston integrally formed at the distal end thereof. By actuating the actuating lever 330, the piston rod 360 is displaceable relative to the main body 310 along a distal feed direction. For this purpose, a plurality of teeth are formed on the underside of the piston rod. The mechanism in question may e.g. be formed according to US 5,992,694. A backstop prevents inadvertent retraction of the piston rod against the feed direction. This lock can be released by operating a release lever 350. A receiving element 340 is inserted laterally into a mounting opening in the housing of the main body 310. The receiving element defines a laterally open insertion opening. In the receiving element 340, an adapter 370 is inserted laterally, which forms an axial passage opening for the passage of the piston rod 360 and has an annular attachment region for fixing the tube 110, which surrounds the passage opening radially. On the inside of the attachment area, an internal thread is formed, which is complementary to the external threads 111, 112 of the tube 110, in order to fix the tube 110 to the discharge device 300.

The discharge device is operated as follows. The tube 110 is inserted counter to the feed direction in the mounting portion of the adapter 370 and screwed by means of its external thread III or 112 therein. It does not depend on the orientation of the tube, i. it does not matter if the tube is screwed in with the end on which the thread 111 is located, or with the end on which the thread 112 is located. This facilitates the surgeon's handling of the tube. Subsequently, the surgeon grasps the device on the handle 320 and pulls the actuating lever 330 with the fingers of the same hand towards the handle 320. Characterized the piston rod 360 is advanced along the feed direction and enters the interior of the tube 110. The dimensions of the integrated piston are chosen so that the piston sealingly abuts the inside of the wall of the tube 110. As a result, the piston presses the material in the tube in the distal direction and carries it out.

Of course, a variety of modifications are possible without departing from the scope of the invention. Thus, the filter can be designed completely differently than in the above examples and can e.g. forming a plug which is pressed into one end of the tube. Accordingly, the filter may also be held on the pipe in a manner other than that exemplified above. Of course, other filling devices than the syringe described above or the funnel described above can be used. The discharge device can also be designed in a different way than described here by way of example.

LIST OF REFERENCE NUMBERS

[0059] <Tb> 100 <September> System <Tb> 110 <September> Pipe <tb> 111, 112 <SEP> male thread <tb> 113 <SEP> fixed component <Tb> 120 <September> Filters <Tb> 130 <September> cap <Tb> 131 <September> internal thread <Tb> 132 <September> through opening <Tb> 140 <September> Stand <Tb> 141 <September> internal thread <Tb> 142 <September> opening <tb> 143 <SEP> outer edge <Tb> 150 <September> Funnels <Tb> 151 <September> internal thread <Tb> 152 <September> filling area <Tb> 160 <September> adapter <Tb> 161 <September> internal thread <Tb> 162 <September> hose connection <Tb> 163 <September> vacuum hose <Tb> 200 <September> Sprayer <Tb> 210 <September> syringe body <Tb> 211 <September> terminal area <Tb> 220 <September> syringe plunger <Tb> 300 <September> discharge <Tb> 310 <September> body <Tb> 320 <September> handle <Tb> 330 <September> Control lever <Tb> 340 <September> receiving element <Tb> 350 <September> release lever <Tb> 360 <September> piston rod <Tb> 370 <September> Adapter

Claims (15)

A system for producing a bone replacement material, comprising: a container (110) in the form of a cylindrical tube having a first end and a second end, the container (110) having a substantially constant inner cross-section over its entire length, characterized in that the system further comprises a retention member (120) connectable to the first end of the container and allowing escape of gases from the container while retaining solids in the container. The system of claim 1, wherein the retaining member (120) is a filter. The system of claim 1 or 2, further comprising: a retaining element adapted to releasably and sealingly retain the retaining element (120) at the first end of the container (110). 4. The system of claim 3, wherein the retaining member (120) is a flat disc filter, and wherein the retaining member is configured to press the filter onto a face boundary surface at the first end of the container (110). 5. System according to claim 3 or 4, wherein at least at the first end of the container outside a first connection structure (111), in particular an external thread, is formed. A system according to claim 5, wherein said holding member has a second connecting structure (131; 141) complementary to said first connecting structure, and said holding member being releasably fixable to said first end of said container (110) by said second connecting structure (131; 141) is. 7. System according to claim 5 or 6, wherein at both ends of the container (110) each outside a first connection structure (111, 112) is formed, and wherein the first connection structures (111, 112) at both ends of the same and preferably substantially identical are. 8. System according to any one of claims 3 to 7, wherein the holding element is designed as a removable cap (130) for the first end of the container (110). A system according to any one of claims 3 to 7, wherein the support member forms a pedestal (140) adapted to be parked on a surface and adapted to receive the first end of the container (110) to hold the container (110) in a vertical orientation. A system according to any one of claims 3 to 7, wherein the retaining element forms an intermediate piece (160) for connection to a vacuum source. A system according to any one of the preceding claims, further comprising a funnel (150) connectable to the second end of the container (110) for filling a solid and / or liquid component into the container. A system according to any one of the preceding claims, wherein the container (110) is prefilled with a solid or semi-solid component of a bone substitute material. A system according to any one of the preceding claims, further comprising a filling device, in particular in the form of a syringe (200), connectable to the second end of the container (110) for filling a liquid component into the container. 14. A system according to any one of the preceding claims, further comprising a discharge device (300), the discharge device comprising: a base body (310) adapted to receive the container (110); a relative to the main body by hand pivotable actuating lever (330); and a piston rod (360) slidable relative to the body and dimensioned to be insertable into the container (110) to squeeze material from the container (110) and coupled to the operating lever (330) an actuation of the actuating lever causes a feed of the piston rod in a distal feed direction. 15. A method for producing a bone substitute material, in particular using a system according to one of the preceding claims, comprising: Providing a container (110) in the form of a cylindrical tube having a first end and a second end, wherein the container (110) has a substantially constant cross-section on its inside over its entire length, the container (110) having a fixed or semi-rigid component of the bone substitute material, and wherein a retaining member (120) is attached to the first end of the container (110), the retaining member (120) allowing gases to exit the container (110) while keeping solids in the container (110 ) withholds; and Filling a liquid component of the bone substitute material with the second end of the container (110).