CH703810B8 - Process for the preparation of a dibenzoxepin compound. - Google Patents

Process for the preparation of a dibenzoxepin compound. Download PDF

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Publication number
CH703810B8
CH703810B8 CH17642011A CH17642011A CH703810B8 CH 703810 B8 CH703810 B8 CH 703810B8 CH 17642011 A CH17642011 A CH 17642011A CH 17642011 A CH17642011 A CH 17642011A CH 703810 B8 CH703810 B8 CH 703810B8
Authority
CH
Switzerland
Prior art keywords
preparation
dibenzoxepin
compound
dibenzoxepin compound
dibenzoxepine
Prior art date
Application number
CH17642011A
Other languages
German (de)
Other versions
CH703810B1 (en
Inventor
Tadashi Katsura
Taketo Hayashi
Kei Komatsu
Masahide Tanaka
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of CH703810B1 publication Critical patent/CH703810B1/en
Publication of CH703810B8 publication Critical patent/CH703810B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(Z)-11-(3-Dimethylaminopropyliden)-6,11-di-hydrodibenzo[b,e]oxepin-2-essigsäure (Freiname: Olopatadin) oder ein Säureadditionssalz davon, die als ein Medikament nützlich ist, wird hergestellt, indem ein Dibenzoxepinderivat, dargestellt durch die Formel [I]: worin R1, R2 und R3 je unabhängig voneinander eine Alkylgruppe mit 1 bis 2 Kohlenstoffatomen bedeuten, mit einem dehydratisierenden Agens umgesetzt wird.(Z) -11- (3-dimethylaminopropylidene) -6,11-di-hydrodibenzo [b, e] oxepin-2-acetic acid (free name: olopatadine) or an acid addition salt thereof, which is useful as a medicament, is prepared by: a dibenzoxepine derivative represented by the formula [I]: wherein R 1, R 2 and R 3 each independently represents an alkyl group having 1 to 2 carbon atoms, is reacted with a dehydrating agent.

CH17642011A 2007-10-05 2008-09-26 Process for the preparation of a dibenzoxepin compound. CH703810B8 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007262591A JP5248078B2 (en) 2007-10-05 2007-10-05 Method for producing dibenzooxepin compound

Publications (2)

Publication Number Publication Date
CH703810B1 CH703810B1 (en) 2012-03-30
CH703810B8 true CH703810B8 (en) 2012-06-15

Family

ID=40526261

Family Applications (2)

Application Number Title Priority Date Filing Date
CH00490/10A CH700067B8 (en) 2007-10-05 2008-09-26 Tertiary alkyl esters of (E, Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid and process for their preparation.
CH17642011A CH703810B8 (en) 2007-10-05 2008-09-26 Process for the preparation of a dibenzoxepin compound.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH00490/10A CH700067B8 (en) 2007-10-05 2008-09-26 Tertiary alkyl esters of (E, Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid and process for their preparation.

Country Status (5)

Country Link
JP (1) JP5248078B2 (en)
CN (1) CN101815709B (en)
CH (2) CH700067B8 (en)
ES (1) ES2344291B1 (en)
WO (1) WO2009044838A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011033532A1 (en) 2009-09-17 2011-03-24 Indoco Remedies Limited Process for preparation of olopatadine hydrochloride
CN107488161A (en) * 2016-06-13 2017-12-19 江苏吉贝尔药业股份有限公司 A kind of light method for transformation of olopatadine N-butyl isomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6310784A (en) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent
JPH11279158A (en) * 1998-02-09 1999-10-12 Pfizer Prod Inc Production of quinazoline-4-one derivative
ES2253996B1 (en) * 2004-07-28 2007-08-16 Urquima, S.A. PROCEDURE FOR THE PREPARATION OF ACID 11 - ((Z) -3- (DIMETHYLAMINE) PROPILIDEN) -6,11-DIHYDRODIBENZ (B, E) OXEPINACETIC.
WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF

Also Published As

Publication number Publication date
WO2009044838A1 (en) 2009-04-09
ES2344291A1 (en) 2010-08-23
ES2344291B1 (en) 2011-05-13
CN101815709B (en) 2015-09-02
JP2009091290A (en) 2009-04-30
JP5248078B2 (en) 2013-07-31
CN101815709A (en) 2010-08-25
CH703810B1 (en) 2012-03-30
CH700067B1 (en) 2012-03-15
CH700067B8 (en) 2012-04-30

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