CH700067B8 - Tertiary alkyl esters of (E, Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid and process for their preparation. - Google Patents

Tertiary alkyl esters of (E, Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid and process for their preparation. Download PDF

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Publication number
CH700067B8
CH700067B8 CH00490/10A CH4902010A CH700067B8 CH 700067 B8 CH700067 B8 CH 700067B8 CH 00490/10 A CH00490/10 A CH 00490/10A CH 4902010 A CH4902010 A CH 4902010A CH 700067 B8 CH700067 B8 CH 700067B8
Authority
CH
Switzerland
Prior art keywords
dimethylaminopropylidene
dihydrodibenzo
oxepin
preparation
acetic acid
Prior art date
Application number
CH00490/10A
Other languages
German (de)
Other versions
CH700067B1 (en
Inventor
Tadashi Katsura
Kei Komatsu
Masahide Tanaka
Taketo Hayashi
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of CH700067B1 publication Critical patent/CH700067B1/en
Publication of CH700067B8 publication Critical patent/CH700067B8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Dibenzoxepinderivat, dargestellt durch die Formel [I]: worin R 1 , R 2 und R 3 je unabhängig voneinander eine Alkylgruppe mit 1 bis 2 Kohlenstoffatomen bedeuten, wird mit einem dehydratisierenden Agens umgesetzt.Dibenzoxepine derivative represented by the formula [I]: wherein R 1, R 2 and R 3 each independently represents an alkyl group having 1 to 2 carbon atoms is reacted with a dehydrating agent.

CH00490/10A 2007-10-05 2008-09-26 Tertiary alkyl esters of (E, Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid and process for their preparation. CH700067B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007262591A JP5248078B2 (en) 2007-10-05 2007-10-05 Method for producing dibenzooxepin compound
PCT/JP2008/067982 WO2009044838A1 (en) 2007-10-05 2008-09-26 Method for producing dibenzoxepin compound

Publications (2)

Publication Number Publication Date
CH700067B1 CH700067B1 (en) 2012-03-15
CH700067B8 true CH700067B8 (en) 2012-04-30

Family

ID=40526261

Family Applications (2)

Application Number Title Priority Date Filing Date
CH00490/10A CH700067B8 (en) 2007-10-05 2008-09-26 Tertiary alkyl esters of (E, Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid and process for their preparation.
CH17642011A CH703810B8 (en) 2007-10-05 2008-09-26 Process for the preparation of a dibenzoxepin compound.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH17642011A CH703810B8 (en) 2007-10-05 2008-09-26 Process for the preparation of a dibenzoxepin compound.

Country Status (5)

Country Link
JP (1) JP5248078B2 (en)
CN (1) CN101815709B (en)
CH (2) CH700067B8 (en)
ES (1) ES2344291B1 (en)
WO (1) WO2009044838A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011033532A1 (en) 2009-09-17 2011-03-24 Indoco Remedies Limited Process for preparation of olopatadine hydrochloride
CN107488161A (en) * 2016-06-13 2017-12-19 江苏吉贝尔药业股份有限公司 A kind of light method for transformation of olopatadine N-butyl isomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6310784A (en) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent
JPH11279158A (en) * 1998-02-09 1999-10-12 Pfizer Prod Inc Production of quinazoline-4-one derivative
ES2253996B1 (en) * 2004-07-28 2007-08-16 Urquima, S.A. PROCEDURE FOR THE PREPARATION OF ACID 11 - ((Z) -3- (DIMETHYLAMINE) PROPILIDEN) -6,11-DIHYDRODIBENZ (B, E) OXEPINACETIC.
WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF

Also Published As

Publication number Publication date
WO2009044838A1 (en) 2009-04-09
ES2344291A1 (en) 2010-08-23
ES2344291B1 (en) 2011-05-13
CN101815709B (en) 2015-09-02
JP2009091290A (en) 2009-04-30
JP5248078B2 (en) 2013-07-31
CN101815709A (en) 2010-08-25
CH703810B1 (en) 2012-03-30
CH703810B8 (en) 2012-06-15
CH700067B1 (en) 2012-03-15

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