CH700068B8 - Process for purifying a dibenzoxepine compound. - Google Patents

Process for purifying a dibenzoxepine compound. Download PDF

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Publication number
CH700068B8
CH700068B8 CH00491/10A CH4912010A CH700068B8 CH 700068 B8 CH700068 B8 CH 700068B8 CH 00491/10 A CH00491/10 A CH 00491/10A CH 4912010 A CH4912010 A CH 4912010A CH 700068 B8 CH700068 B8 CH 700068B8
Authority
CH
Switzerland
Prior art keywords
dimethylaminopropylidene
dihydrodibenzo
oxepin
addition salt
acetic acid
Prior art date
Application number
CH00491/10A
Other languages
German (de)
Other versions
CH700068B1 (en
Inventor
Tadashi Katsura
Taketo Hayashi
Kei Komatsu
Masahide Tanaka
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of CH700068B1 publication Critical patent/CH700068B1/en
Publication of CH700068B8 publication Critical patent/CH700068B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Abstract

(Z)-11-(3-Dimethylaminopropyliden)-6,11-di-hydrodibenzo [b,e]oxepin-2-essigsäure oder ein Säureadditionssalz davon, die als medizinische Zusätze nützlich sind, können effizient und gewerblich vorteilhaft mittels eines Verfahrens zur Reinigung von (Z)-11-(3-Dimethylaminopropyliden)-6,11-dihydrodibenzo[b,e]oxepin-2-essigsäure oder einem Säureadditionssalz davon hergestellt werden, welches Verfahren das Auflösen von (Z)-11-(3-Dimethylaminopropyliden)-6,11-dihydrodibenzo[b,e]oxepin-2-essigsäure, dargestellt durch die Formel [I]: oder einem Säureadditionssalz davon in einem aus Wasser und einem Keton-Lösungsmittel gemischten Lösungsmittel und das Fällen von Kristallen aus der erhaltenen Lösung umfasst.(Z) -11- (3-Dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid or an acid addition salt thereof, which are useful as medicinal additives, can be efficiently and industrially advantageously obtained by a method of Purification of (Z) -11- (3-dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid or an acid addition salt thereof, which process comprises dissolving (Z) -11- (3) Dimethylaminopropylidene) -6,11-dihydrodibenzo [b, e] oxepin-2-acetic acid represented by the formula [I]: or an acid addition salt thereof in a solvent mixed with water and a ketone solvent and precipitating crystals from the obtained one Solution includes.

CH00491/10A 2007-10-12 2008-10-02 Process for purifying a dibenzoxepine compound. CH700068B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007267156 2007-10-12
PCT/JP2008/068325 WO2009048086A1 (en) 2007-10-12 2008-10-02 Method for purification of dibenzoxepin compound

Publications (2)

Publication Number Publication Date
CH700068B1 CH700068B1 (en) 2012-07-31
CH700068B8 true CH700068B8 (en) 2012-09-14

Family

ID=40549229

Family Applications (1)

Application Number Title Priority Date Filing Date
CH00491/10A CH700068B8 (en) 2007-10-12 2008-10-02 Process for purifying a dibenzoxepine compound.

Country Status (4)

Country Link
JP (1) JP5325517B2 (en)
CN (1) CN101815708A (en)
CH (1) CH700068B8 (en)
WO (1) WO2009048086A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102668626A (en) 2010-01-07 2012-09-12 日本电气株式会社 Wireless communication system, radio terminal, radio network, wireless communication method and program
JP2016010418A (en) 2012-10-22 2016-01-21 パナソニックヘルスケア株式会社 Dental vibration application device and dental vibration application method
CN112375060B (en) * 2020-12-07 2022-02-22 广州健康元呼吸药物工程技术有限公司 Post-treatment purification method of olopatadine hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE243692T1 (en) * 1999-11-29 2003-07-15 Aventis Pharma Sa ARYLAMINE DERIVATIVES AND USE THEREOF AS ANTITELOMERASE AGENTS
AR040661A1 (en) * 2002-07-26 2005-04-13 Theravance Inc CRYSTAL DICHLORHYDRATE OF N- {2 - [- ((R) -2-HYDROXI-2-PHENYLETHYLAMINE) PHENYL] ETIL} - (R) -2 HYDROXY-2- (3-FORMAMIDE-4-HYDROXYPHENYL) ETHYLAMINE, RECEIVER AGONIST BETA 2 ADRENERGIC
JP4279087B2 (en) * 2003-08-22 2009-06-17 旭化成ケミカルズ株式会社 Electrolytic solution for electrolytic capacitors
JP2005298405A (en) * 2004-04-12 2005-10-27 Kuraray Co Ltd Production method for cis-1-amino-4-hydroxymethyl-2-cyclopentene or its salt
WO2007119120A2 (en) * 2005-12-22 2007-10-25 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation
WO2007105234A2 (en) * 2006-03-14 2007-09-20 Usv Limited A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
WO2008099900A1 (en) * 2007-02-16 2008-08-21 Sumitomo Chemical Company, Limited Process for production of dibenzoxepin compound
JP5139104B2 (en) * 2007-02-16 2013-02-06 住友化学株式会社 Method for producing dibenzooxepin compound

Also Published As

Publication number Publication date
JP5325517B2 (en) 2013-10-23
CH700068B1 (en) 2012-07-31
WO2009048086A1 (en) 2009-04-16
JP2009108039A (en) 2009-05-21
CN101815708A (en) 2010-08-25

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Free format text: NEW ADDRESS: HOLBEINSTRASSE 36-38, 4051 BASEL (CH)

PL Patent ceased