CH654830A5 - Aziridine derivative - Google Patents
Aziridine derivative Download PDFInfo
- Publication number
- CH654830A5 CH654830A5 CH2979/84A CH297984A CH654830A5 CH 654830 A5 CH654830 A5 CH 654830A5 CH 2979/84 A CH2979/84 A CH 2979/84A CH 297984 A CH297984 A CH 297984A CH 654830 A5 CH654830 A5 CH 654830A5
- Authority
- CH
- Switzerland
- Prior art keywords
- formula
- group
- methyl
- ethylene
- nitromethylene
- Prior art date
Links
- 150000001541 aziridines Chemical class 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 7
- 229960000620 ranitidine Drugs 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims abstract description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- -1 nitromethylene Chemical group 0.000 claims description 8
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims description 6
- ZVIREQPONFZPLQ-UHFFFAOYSA-N 1-nitroethenamine Chemical compound NC(=C)[N+]([O-])=O ZVIREQPONFZPLQ-UHFFFAOYSA-N 0.000 claims description 4
- 125000004414 alkyl thio group Chemical group 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 150000002240 furans Chemical class 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 229940100198 alkylating agent Drugs 0.000 claims description 2
- 239000002168 alkylating agent Substances 0.000 claims description 2
- 239000000010 aprotic solvent Substances 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000003485 histamine H2 receptor antagonist Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims description 2
- BKPFPICPGCKKAA-UHFFFAOYSA-N 1-(aziridin-1-yl)-n-methyl-2-nitroethenamine Chemical compound [O-][N+](=O)C=C(NC)N1CC1 BKPFPICPGCKKAA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
- C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8000580 | 1980-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH654830A5 true CH654830A5 (en) | 1986-03-14 |
Family
ID=10510510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH2979/84A CH654830A5 (en) | 1980-01-08 | 1981-01-08 | Aziridine derivative |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS56103171A (en, 2012) |
| KR (1) | KR840002007B1 (en, 2012) |
| BE (1) | BE886997A (en, 2012) |
| CH (1) | CH654830A5 (en, 2012) |
| GB (1) | GB2067991B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399294A (en) * | 1980-12-30 | 1983-08-16 | Glaxo Group Limited | Process for the preparation of a furan derivative |
| KR860000063B1 (ko) * | 1980-12-30 | 1986-02-06 | 그랙소 그룹 리밋티드 | 푸란유도체의 제조방법 |
| EP0058492A1 (en) * | 1981-02-03 | 1982-08-25 | Glaxo Group Limited | Nitrovinyl derivatives for use in therapy and pharmaceutical compositions containing them |
| FI76080C (fi) * | 1981-02-20 | 1988-09-09 | Glaxo Group Ltd | Foerfarande foer framstaellning av furanderivat. |
| DE3213509A1 (de) * | 1982-04-10 | 1983-10-20 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
| FI88157C (fi) * | 1983-07-15 | 1993-04-13 | Richter Gedeon Vegyeszet | Foerfarande foer framstaellning av vaetekloriden av 1- 2-/5-dimetylaminometyl-2-(furylmetyltio)-etyl/ -amino-1-metylamino-2-nitroetylen |
| US5686588A (en) * | 1995-08-16 | 1997-11-11 | Yoo; Seo Hong | Amine acid salt compounds and process for the production thereof |
-
1981
- 1981-01-08 BE BE0/203425A patent/BE886997A/fr not_active IP Right Cessation
- 1981-01-08 KR KR1019810000033A patent/KR840002007B1/ko not_active Expired
- 1981-01-08 GB GB8100477A patent/GB2067991B/en not_active Expired
- 1981-01-08 JP JP83381A patent/JPS56103171A/ja active Granted
- 1981-01-08 CH CH2979/84A patent/CH654830A5/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR830005191A (ko) | 1983-08-03 |
| BE886997A (fr) | 1981-07-08 |
| JPS56103171A (en) | 1981-08-18 |
| JPH0224827B2 (en, 2012) | 1990-05-30 |
| GB2067991A (en) | 1981-08-05 |
| KR840002007B1 (ko) | 1984-10-27 |
| GB2067991B (en) | 1983-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |