CH534165A - Verfahren zur Herstellung von 2,3,5-trisubstit.-2'-Hydroxy-6,7-benzomorphanen - Google Patents

Verfahren zur Herstellung von 2,3,5-trisubstit.-2'-Hydroxy-6,7-benzomorphanen

Info

Publication number
CH534165A
CH534165A CH82970A CH82970A CH534165A CH 534165 A CH534165 A CH 534165A CH 82970 A CH82970 A CH 82970A CH 82970 A CH82970 A CH 82970A CH 534165 A CH534165 A CH 534165A
Authority
CH
Switzerland
Prior art keywords
benzomorphans
trisubstituted
hydroxy
preparation
Prior art date
Application number
CH82970A
Other languages
English (en)
Inventor
Moore Robinson Franklin
Stanley Anderson Paul
Original Assignee
Merck & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Ltd filed Critical Merck & Co Ltd
Publication of CH534165A publication Critical patent/CH534165A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH82970A 1969-01-23 1970-01-21 Verfahren zur Herstellung von 2,3,5-trisubstit.-2'-Hydroxy-6,7-benzomorphanen CH534165A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79357169A 1969-01-23 1969-01-23

Publications (1)

Publication Number Publication Date
CH534165A true CH534165A (de) 1973-02-28

Family

ID=25160225

Family Applications (1)

Application Number Title Priority Date Filing Date
CH82970A CH534165A (de) 1969-01-23 1970-01-21 Verfahren zur Herstellung von 2,3,5-trisubstit.-2'-Hydroxy-6,7-benzomorphanen

Country Status (7)

Country Link
US (1) US3700734A (de)
BR (1) BR6914877D0 (de)
CH (1) CH534165A (de)
DE (1) DE2002840C3 (de)
FR (1) FR2034485B1 (de)
GB (1) GB1261693A (de)
NL (1) NL7000166A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161598A (en) * 1972-05-26 1979-07-17 Sterling Drug Inc. 1-Oxygenated-2,6-methano-3-benzazocines
US3891657A (en) * 1972-10-26 1975-06-24 Bristol Myers Co 9Beta-hydroxy-5-methyl-6,7-benzomorphans
US3966747A (en) * 1972-10-26 1976-06-29 Bristol-Myers Company 9-Hydroxy-6,7-benzomorphans
JPS5817190B2 (ja) * 1973-03-31 1983-04-05 住友化学工業株式会社 シンキナ ４，５− ジアルキルベンゾモルフアンユウドウタイノセイホウ
US3959290A (en) * 1973-07-18 1976-05-25 Bristol-Myers Company 3,14-Substituted-8-oxamorphinans
US3853889A (en) * 1973-07-18 1974-12-10 Bristol Myers Co 3,14-substituted-8-oxamorphinans
US3891658A (en) * 1973-08-29 1975-06-24 Purdue Research Foundation N-Phenethyl trialkylmethanobenz-azolines
US3892757A (en) * 1973-08-29 1975-07-01 Purdue Research Foundation Trialkylmethanobenzazocinols
US4009171A (en) * 1974-02-21 1977-02-22 Sterling Drug Inc. N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
US4022789A (en) * 1975-11-20 1977-05-10 Sterling Drug Inc. Dichlorocyclopropylmethyl-benzazocines
US4205171A (en) * 1976-01-12 1980-05-27 Sterling Drug Inc. Aminomethanobenzazocines and nitromethanobenzazocines
US4374991A (en) 1976-12-17 1983-02-22 Rohm And Haas Company 2,6-Dimethylpiperidinyl-N-carbobutoxymethyl urea
US4357471A (en) 1976-12-17 1982-11-02 Rohm And Haas Company Azaspiro compounds
US4400512A (en) * 1976-12-17 1983-08-23 Rohm And Haas Company Azaspiro compounds
US4341904A (en) * 1980-02-19 1982-07-27 Merck & Co., Inc. Derivatives of 2-hydroxy-6,9-methano-11-amino-5,6,7,8,9,10-hexahydro-benzocyclooctene
US4405630A (en) * 1980-12-29 1983-09-20 Rohm And Haas Company Arthropod repellent compositions and methods
US4332807A (en) * 1981-01-26 1982-06-01 Merck & Co., Inc. N-Substituted-benzyl-11-endo-amino-5,6,7,8,9,10-hexahydro-2-hydroxy (or methoxy)-6,9-methanobenzocyclooctene (or nonene) centrally-acting analgesics
US4332810A (en) * 1981-01-26 1982-06-01 Merck & Co., Inc. N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics
US4376779A (en) * 1981-01-26 1983-03-15 Merck Sharp & Dohme (I.A.) Corp. N-(Substituted)-2-aza-2'-hydroxy-5,6-benzotricyclo[6.3.01,8.04,11 ] undecane centrally-acting analgesics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1915334A (en) * 1930-10-16 1933-06-27 Du Pont Fluosilicate of organic heterocyclic bases and process of making it
US3138603A (en) * 1958-10-31 1964-06-23 Everette L May New benzomorphans (methanobenzazocines) and preparation thereof
US3372165A (en) * 1960-12-01 1968-03-05 Sterling Drug Inc 1, 2, 3, 4, 5, 6-hexahydro-8-hydroxy-2, 6-methano-3-benzazocine derivatives
GB997637A (en) * 1962-01-31 1965-07-07 Smith Kline French Lab Substituted 2-cyclopropylmethyl-6,7-benzmorphans
US3250678A (en) * 1963-01-16 1966-05-10 Sterling Drug Inc Analgesia producing benzazocines
GB1050227A (de) * 1963-11-07
US3345373A (en) * 1964-05-25 1967-10-03 Smith Kline French Lab 2-polymethylallyl-5, 9-dimethyl-6, 7-benzmorphans and derivatives
NL132138C (de) * 1966-05-20
NL132139C (de) * 1966-05-20

Also Published As

Publication number Publication date
NL7000166A (de) 1970-07-27
FR2034485B1 (de) 1974-01-11
DE2002840C3 (de) 1980-04-10
GB1261693A (en) 1972-01-26
DE2002840A1 (de) 1970-08-06
FR2034485A1 (de) 1970-12-11
DE2002840B2 (de) 1979-08-02
BR6914877D0 (pt) 1973-02-08
US3700734A (en) 1972-10-24

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