CH523890A - Procédé pour la préparation de phthalazines - Google Patents

Procédé pour la préparation de phthalazines

Info

Publication number
CH523890A
CH523890A CH661970A CH661970A CH523890A CH 523890 A CH523890 A CH 523890A CH 661970 A CH661970 A CH 661970A CH 661970 A CH661970 A CH 661970A CH 523890 A CH523890 A CH 523890A
Authority
CH
Switzerland
Prior art keywords
phthalazines
preparation
Prior art date
Application number
CH661970A
Other languages
English (en)
French (fr)
Inventor
Ernest Rodway Ronald
George Simmonds Robin
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Publication of CH523890A publication Critical patent/CH523890A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH661970A 1969-05-03 1970-05-02 Procédé pour la préparation de phthalazines CH523890A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB22679/69A GB1293565A (en) 1969-05-03 1969-05-03 Aminophthalazines and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
CH523890A true CH523890A (fr) 1972-06-15

Family

ID=10183355

Family Applications (1)

Application Number Title Priority Date Filing Date
CH661970A CH523890A (fr) 1969-05-03 1970-05-02 Procédé pour la préparation de phthalazines

Country Status (9)

Country Link
US (1) US3753988A (enExample)
JP (1) JPS4839944B1 (enExample)
BE (1) BE749824A (enExample)
CH (1) CH523890A (enExample)
DE (1) DE2021195A1 (enExample)
FR (1) FR2043504B1 (enExample)
GB (1) GB1293565A (enExample)
IE (1) IE33777B1 (enExample)
SE (1) SE376916B (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN148482B (enExample) 1977-06-03 1981-03-07 Pfizer
US4370328A (en) 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
CA1114379A (en) * 1977-11-03 1981-12-15 Pfizer Corporation Piperidino-phthalazines
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
EP0174464B1 (de) * 1984-09-14 1990-01-03 ASTA Pharma AG Substituierte Benzylphthalazinon-Derivate
US4868179A (en) * 1987-04-22 1989-09-19 Cohn Jay N Method of reducing mortality associated with congestive heart failure using hydralazine and isosorbide dinitrate
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US4963676A (en) * 1988-02-09 1990-10-16 Georgia State University Foundation, Inc. Di-substituted phthalazines
JO1645B1 (en) * 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
DE69105572T2 (de) * 1990-03-30 1995-05-11 Mitsubishi Chem Ind 4-Phenylphthalazin-Derivate.
US5100893A (en) * 1990-04-18 1992-03-31 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
TW279162B (enExample) * 1991-09-26 1996-06-21 Mitsubishi Chem Corp
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
US5716956A (en) * 1995-06-07 1998-02-10 Bearsden Bearsden Bio, Inc. Dihydrophthalazine antagonists of excitatory amino acid receptors
ATE236134T1 (de) * 1996-12-18 2003-04-15 Neurogen Corp Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
CN1660840A (zh) 1999-03-30 2005-08-31 诺瓦提斯公司 治疗炎性疾病的酞嗪衍生物
AR025068A1 (es) * 1999-08-10 2002-11-06 Bayer Corp Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
US6689883B1 (en) 1999-09-28 2004-02-10 Bayer Pharmaceuticals Corporation Substituted pyridines and pyridazines with angiogenesis inhibiting activity
DOP2000000070A (es) * 1999-09-28 2002-02-28 Bayer Healthcare Llc Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
US7977333B2 (en) * 2000-04-20 2011-07-12 Bayer Healthcare Llc Substituted pyridines and pyridazines with angiogenesis inhibiting activity
AR028782A1 (es) * 2000-07-05 2003-05-21 Taisho Pharmaceutical Co Ltd Derivados heterociclicos tetrahidropiridino o piperidino
US6903101B1 (en) 2000-08-10 2005-06-07 Bayer Pharmaceuticals Corporation Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
GB0111078D0 (en) * 2001-05-04 2001-06-27 Novartis Ag Organic compounds
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
GB0223341D0 (en) * 2002-10-08 2002-11-13 Groningen Acad Ziekenhuis Organic compounds
GB0310726D0 (en) 2003-05-09 2003-06-11 Merck Sharp & Dohme Therapeutic agents
CA2546002C (en) * 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
BRPI0416206A (pt) 2003-11-20 2006-12-26 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose)
SG151249A1 (en) * 2003-12-05 2009-04-30 Janssen Pharmaceutica Nv 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
WO2006004589A2 (en) * 2004-05-08 2006-01-12 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines
JP4446047B2 (ja) * 2004-06-02 2010-04-07 ケイティー コーポレーション アプリケーション及び管理サービスの提供、並びに使用者インターフェースの変更システム及びその方法
ATE540936T1 (de) * 2004-06-30 2012-01-15 Janssen Pharmaceutica Nv Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer
EA011552B1 (ru) 2004-06-30 2009-04-28 Янссен Фармацевтика Н.В. Производные хиназолиндиона в качестве ингибиторов parp
SG154433A1 (en) * 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Phthalazine derivatives as parp inhibitors
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS RELATED TO HEART ERROR
JP5607291B2 (ja) * 2004-11-24 2014-10-15 メダ ファーマシューティカルズ インコーポレイテッド アゼラスチンを含む組成物およびその使用方法
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
JP2009524637A (ja) * 2006-01-27 2009-07-02 ファイザー・プロダクツ・インク アミノフタラジン誘導体化合物
AU2007217980A1 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
EP2024337A4 (en) * 2006-05-16 2011-09-14 Nitromed Inc SOLID DOSAGE FORMULATIONS OF HYDRALAZIN COMPOUNDS
EP2402324A1 (en) * 2006-05-29 2012-01-04 High Point Pharmaceuticals, LLC Benzodioxolylcyclopropylpiperazinylpyridazines
US8299256B2 (en) * 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
CA2681162C (en) * 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US8404713B2 (en) * 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
ES2367760T3 (es) * 2008-03-27 2011-11-08 Janssen Pharmaceutica, N.V. Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.
CN101981013B (zh) 2008-03-27 2013-05-29 詹森药业有限公司 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
UA102250C2 (ru) * 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
MX2011004683A (es) * 2008-11-03 2011-06-20 Lilly Co Eli Antagonistas de la via hedgehog de ftalazina disustituida.
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
BRPI0921777A2 (pt) * 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
US20180093956A1 (en) * 2015-02-06 2018-04-05 Abbvie Inc. Substituted phthalazines
US10947241B2 (en) * 2016-10-28 2021-03-16 Seoul National University Hospital Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
JP2024505256A (ja) * 2021-01-28 2024-02-05 ユニバーシティ オブ フロリダ リサーチファウンデーション インコーポレイティッド 神経変性、変性及び代謝性障害の処置のための化合物並びにその使用
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
CN115433163A (zh) * 2021-06-05 2022-12-06 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
WO2023051761A1 (zh) * 2021-09-30 2023-04-06 成都奥睿药业有限公司 一类取代杂芳酞嗪衍生物的药学用途及其制备方法
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors

Also Published As

Publication number Publication date
IE33777B1 (en) 1974-10-30
IE33777L (en) 1970-11-03
JPS4839944B1 (enExample) 1973-11-28
SE376916B (enExample) 1975-06-16
US3753988A (en) 1973-08-21
GB1293565A (en) 1972-10-18
FR2043504B1 (enExample) 1974-10-11
DE2021195A1 (de) 1970-11-12
BE749824A (fr) 1970-10-30
FR2043504A1 (enExample) 1971-02-19

Similar Documents

Publication Publication Date Title
CH523890A (fr) Procédé pour la préparation de phthalazines
CH514585A (fr) Procédé de préparation de bis-maléimides
CH526571A (fr) Procédé de préparation de 3-alcoxy-thianaphtène-2-carboxamides
FR1505657A (fr) Procédé pour la préparation de diphénylalcoylamines substituées
FR1508526A (fr) Procédé pour la préparation de maléimides
CH481115A (fr) Procédé pour la préparation de nouvelles cinnamylpipérazines
CH447192A (fr) Procédé pour la préparation de nitrodiarylamines
FR1533763A (fr) Procédé pour la préparation de thio-semicarbazides
CH521979A (fr) Procédé pour la préparation d'hexahydro-imidazoquinoléines substituées
CH532032A (fr) Procédé pour la préparation de chromones
FR1441516A (fr) Procédé pour la préparation de nitro-4-pyrazoles
CH511249A (fr) Procédé de préparation d'oxo-dihydro-benzothiazine-S-dioxydes
CH501629A (fr) Procédé de préparation de dihydro-isoquinoléine-carboxamidoximes
CH518886A (fr) Procédé de préparation de méthylcyclohexènes
CH523283A (fr) Procédé de préparation d'a-uréidocyclohexadiénylalcoylène-pénicillines
CH522648A (fr) Procédé de préparation de benzo-lactames
CH503717A (fr) Procédé pour la préparation de 3-éthers de la 17a-dihydroéquilénine
CH507247A (fr) Procédé de préparation du dipropylacétyl-homatropine
CH528534A (fr) Procédé pour la préparation de thiéno-benzopyrannes et thiopyrano-benzopyrannes
CH509308A (fr) Procédé de préparation de 1-phénylpyrrols halogénés
CH509284A (fr) Procédé de préparation de p-aminobenzènesulfonylcarbamate de méthyle
CH509406A (fr) Procédé de préparation de la janiémycine
FR1522917A (fr) Procédé pour la préparation de cyclopent-2-énones substituées
CH520115A (fr) Procédé de préparation de nitriles
FR1510878A (fr) Procédé pour la préparation de benzindènes

Legal Events

Date Code Title Description
PL Patent ceased