|
GB1188529A
(en)
*
|
1966-06-09 |
1970-04-15 |
Wellcome Found |
Pyramidine Derivatives
|
|
US3763156A
(en)
*
|
1970-01-28 |
1973-10-02 |
Boehringer Sohn Ingelheim |
2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines
|
|
RO62428A
(fr)
*
|
1971-05-04 |
1978-01-15 |
Thomae Gmbh Dr K |
Procede pour la preparation des thyeno-(3,2-d)-pyrimidines
|
|
GB1570494A
(en)
|
1975-11-28 |
1980-07-02 |
Ici Ltd |
Thienopyrimidine derivatives and their use as pesticides
|
|
US4703120A
(en)
*
|
1986-04-28 |
1987-10-27 |
Ortho Pharmaceutical Corporation |
Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
|
|
US4670560A
(en)
*
|
1986-04-28 |
1987-06-02 |
Ortho Pharmaceutical Corporation |
Thienopyrimidine-2,4-dione derivatives and intermediates thereof
|
|
EP0276057B1
(de)
*
|
1987-01-21 |
1994-03-09 |
Merck & Co. Inc. |
Piperazinylpyrimidine als beta-adrenergische Rezeptoren blockierende Mittel
|
|
US5098902A
(en)
*
|
1991-03-18 |
1992-03-24 |
Warner-Lambert Company |
Method of treating neurodegenerative diseases
|
|
US6339089B2
(en)
*
|
1997-08-13 |
2002-01-15 |
Fujirebio Inc. |
Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
|
|
DE19944604A1
(de)
*
|
1999-09-17 |
2001-03-22 |
Merck Patent Gmbh |
Aminderivate
|
|
US6503914B1
(en)
*
|
2000-10-23 |
2003-01-07 |
Board Of Regents, The University Of Texas System |
Thienopyrimidine-based inhibitors of the Src family
|
|
WO2003055890A1
(en)
*
|
2001-12-21 |
2003-07-10 |
Bayer Pharmaceuticals Corporation |
Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
|
|
TW200410975A
(en)
*
|
2002-09-26 |
2004-07-01 |
Nihon Nohyaku Co Ltd |
New pesticide and method for using it, new substituted thienopyrimidine derivative, its intermediate, and method for producing it
|
|
GB0423653D0
(en)
*
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
CN101163706A
(zh)
*
|
2005-04-21 |
2008-04-16 |
贝林格尔·英格海姆国际有限公司 |
用于治疗炎性疾病的二氢噻吩并嘧啶
|
|
EP1847543A1
(de)
|
2006-04-19 |
2007-10-24 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
|
|
KR101533461B1
(ko)
|
2006-04-26 |
2015-07-02 |
에프. 호프만-라 로슈 아게 |
Ｐｉ３ｋ저해제로 유용한 티에노［3,2-ｄ］피리미딘 유도체
|
|
PL2041139T3
(pl)
|
2006-04-26 |
2012-05-31 |
Hoffmann La Roche |
Związki farmaceutyczne
|
|
MX2008013583A
(es)
|
2006-04-26 |
2008-10-31 |
Genentech Inc |
Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen.
|
|
PE20081679A1
(es)
|
2006-12-07 |
2008-12-18 |
Hoffmann La Roche |
Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
|
|
AR064154A1
(es)
*
|
2006-12-07 |
2009-03-18 |
Piramed Ltd |
Compuestos inhibidores de fodfoinostida 3- quinasas y composiciones farmaceuticas
|
|
JP5439377B2
(ja)
|
2007-09-14 |
2014-03-12 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ヒスタミンｈ４受容体のチエノ−及びフロ−ピリミジン調節物質
|
|
JP5736171B2
(ja)
|
2007-09-24 |
2015-06-17 |
ジェネンテック， インコーポレイテッド |
チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法
|
|
ATE537175T1
(de)
|
2007-10-19 |
2011-12-15 |
Boehringer Ingelheim Int |
Neue piperazino-dihydrothienopyrimidin-derivate
|
|
ES2524910T3
(es)
|
2007-10-19 |
2014-12-15 |
Boehringer Ingelheim International Gmbh |
Piperidino-dihidrotienopirimidinas sustituidas
|
|
JP5341899B2
(ja)
|
2007-10-19 |
2013-11-13 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ヘテロ環置換ピペラジノ−ジヒドロチエノピリミジン
|
|
EP2214675B1
(de)
|
2007-10-25 |
2013-11-20 |
Genentech, Inc. |
Verfahren zur herstellung von thienopyrimidin-verbindungen
|
|
GB0721095D0
(en)
*
|
2007-10-26 |
2007-12-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
US8354408B2
(en)
*
|
2007-11-15 |
2013-01-15 |
Ym Biosciences Australia Pty Ltd |
N-containing heterocyclic compounds
|
|
BRPI1006189A2
(pt)
|
2009-03-12 |
2020-08-18 |
Genentech Inc |
uso de uma combinação terapêutica, formulação farmacêutica, artigo de manufatura, produto, método para determinar compostos a serem utilizados em combinação para o tratamento de uma malignidade hematopoiética e método para selecionar compostos a serem utilizados em combinação para o tratamento de câncer
|
|
US8173650B2
(en)
|
2009-05-27 |
2012-05-08 |
Genentech, Inc. |
Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
|
|
WO2010136491A1
(en)
*
|
2009-05-27 |
2010-12-02 |
F. Hoffmann-La Roche Ag |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
US20110086837A1
(en)
*
|
2009-10-12 |
2011-04-14 |
Genentech, Inc. |
Combinations of a pi3k inhibitor and a mek inhibitor
|
|
CN103038643A
(zh)
|
2010-04-16 |
2013-04-10 |
基因泰克公司 |
作为pi3k/akt激酶途径抑制剂效能的预测性生物标记的foxo3a
|
|
WO2012088254A1
(en)
|
2010-12-22 |
2012-06-28 |
Genentech, Inc. |
Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
|
|
US20130059866A1
(en)
|
2011-08-24 |
2013-03-07 |
Boehringer Ingelheim International Gmbh |
Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
|
|
US9802954B2
(en)
|
2011-08-24 |
2017-10-31 |
Boehringer Ingelheim International Gmbh |
Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
|
|
FR2988722B1
(fr)
*
|
2012-04-03 |
2014-05-09 |
Sanofi Sa |
Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
|
|
US9499561B2
(en)
*
|
2012-04-10 |
2016-11-22 |
Shanghai Yingli Pharmaceutical Co., Ltd. |
Fused pyrimidine compound, and preparation method, intermediate, composition, and uses thereof
|
|
WO2014130923A2
(en)
|
2013-02-25 |
2014-08-28 |
Genentech, Inc. |
Methods and compositions for detecting and treating drug resistant akt mutant
|
|
CN103242341B
(zh)
*
|
2013-04-19 |
2015-12-09 |
中国科学院广州生物医药与健康研究院 |
噻吩并2，4取代嘧啶类化合物及其药物组合物与应用
|
|
WO2015043398A1
(zh)
*
|
2013-09-30 |
2015-04-02 |
上海璎黎药业有限公司 |
稠合嘧啶类化合物、中间体、其制备方法、组合物和应用
|
|
RU2545758C1
(ru)
*
|
2014-03-20 |
2015-04-10 |
Общество с ограниченной ответственностью "Алион" |
Бициклические пиримидины или их фармацевтически приемлемые соли-активаторы антиоксидантной программы и их применение в качестве цитопротекторов
|
|
US10174032B2
(en)
*
|
2014-05-05 |
2019-01-08 |
Signalrx Pharmaceuticals, Inc. |
Heterocyclic compound classes for signaling modulation
|
|
GB201410816D0
(en)
*
|
2014-06-17 |
2014-07-30 |
Ucb Biopharma Sprl And Katholieke Universiteit Leuven |
Therapeutic agents
|
|
US10646490B2
(en)
|
2015-03-02 |
2020-05-12 |
University Of Maryland, Baltimore County |
Thieno- and pyrrolopyrimidine analogues and prodrugs thereof as anticancer agents and methods of use thereof
|
|
US9434742B1
(en)
*
|
2015-03-02 |
2016-09-06 |
University Of Maryland, Baltimore County |
Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
|
|
EP3324974B1
(de)
*
|
2015-07-24 |
2022-06-08 |
University Of Louisville Research Foundation, Inc. |
Verbindungen, zusammensetzungen, verfahren zur behandlung von erkrankungen und verfahren zur zubereitung von verbindungen
|
|
DE102015012049A1
(de)
*
|
2015-09-15 |
2017-03-16 |
Merck Patent Gmbh |
Verbindungen als ASIC-Inhibitoren und deren Verwendungen
|
|
EP3380476B1
(de)
|
2015-11-23 |
2020-09-30 |
Council of Scientific and Industrial Research |
Kondensierte pyrimidine als isoformselektive phosphoinositid-3-kinase-alpha-inhibitoren und verfahren zur herstellung davon
|
|
EP3394056B1
(de)
|
2015-12-22 |
2021-04-14 |
Shy Therapeutics LLC |
Verbindungen zur behandlung von krebs und entzündungskrankheiten
|
|
CN105820175B
(zh)
*
|
2016-04-13 |
2019-09-20 |
四川大学 |
一种噻吩并嘧啶类化合物及其制备方法和应用
|
|
CN107698603B
(zh)
*
|
2016-08-09 |
2022-04-08 |
南京红云生物科技有限公司 |
噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用
|
|
GB201700814D0
(en)
*
|
2017-01-17 |
2017-03-01 |
Liverpool School Tropical Medicine |
Compounds
|
|
CA3066939A1
(en)
|
2017-06-21 |
2018-12-27 |
SHY Therapeutics LLC |
Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
US12391705B2
(en)
|
2018-12-19 |
2025-08-19 |
Shy Therapeutics, Llc |
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
JP7659269B2
(ja)
*
|
2018-12-21 |
2025-04-09 |
ユニバーシティ・オブ・ノートル・ダム・デュ・ラック |
抗酸菌症治療のためのｂｄオキシダーゼ阻害剤の発見
|
|
CA3129067A1
(en)
|
2019-02-13 |
2020-08-20 |
Ptc Therapeutics, Inc. |
Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia
|
|
WO2020167624A1
(en)
|
2019-02-13 |
2020-08-20 |
Ptc Therapeutics, Inc. |
Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia
|
|
CN118401243A
(zh)
*
|
2021-09-07 |
2024-07-26 |
Ptc医疗公司 |
治疗神经退行性疾病的方法
|
|
CN115991716B
(zh)
*
|
2021-10-19 |
2025-10-17 |
中国药科大学 |
嘧啶并环类化合物及其衍生物、制备方法、药物组合物和应用
|