CH446361A - Verfahren zur Herstellung von neuen Thieno(3,2-d)pyrimidinen - Google Patents

Verfahren zur Herstellung von neuen Thieno(3,2-d)pyrimidinen

Info

Publication number
CH446361A
CH446361A CH44865A CH44865A CH446361A CH 446361 A CH446361 A CH 446361A CH 44865 A CH44865 A CH 44865A CH 44865 A CH44865 A CH 44865A CH 446361 A CH446361 A CH 446361A
Authority
CH
Switzerland
Prior art keywords
pyrimidines
preparation
new thieno
thieno
new
Prior art date
Application number
CH44865A
Other languages
English (en)
Inventor
Eberhard Dr Woitun
Gerhard Dr Ohnacker
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CH446361A publication Critical patent/CH446361A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH44865A 1964-01-15 1965-01-13 Verfahren zur Herstellung von neuen Thieno(3,2-d)pyrimidinen CH446361A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DET0025430 1964-01-15

Publications (1)

Publication Number Publication Date
CH446361A true CH446361A (de) 1967-11-15

Family

ID=7552062

Family Applications (1)

Application Number Title Priority Date Filing Date
CH44865A CH446361A (de) 1964-01-15 1965-01-13 Verfahren zur Herstellung von neuen Thieno(3,2-d)pyrimidinen

Country Status (5)

Country Link
US (1) US3475429A (de)
CH (1) CH446361A (de)
DE (1) DE1470356A1 (de)
FR (2) FR1603313A (de)
GB (1) GB1057612A (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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GB1570494A (en) 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
US4703120A (en) * 1986-04-28 1987-10-27 Ortho Pharmaceutical Corporation Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
US4670560A (en) * 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
EP0276057B1 (de) * 1987-01-21 1994-03-09 Merck & Co. Inc. Piperazinylpyrimidine als beta-adrenergische Rezeptoren blockierende Mittel
US5098902A (en) * 1991-03-18 1992-03-24 Warner-Lambert Company Method of treating neurodegenerative diseases
US6339089B2 (en) * 1997-08-13 2002-01-15 Fujirebio Inc. Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
US6503914B1 (en) * 2000-10-23 2003-01-07 Board Of Regents, The University Of Texas System Thienopyrimidine-based inhibitors of the Src family
AU2002364211A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
AR044743A1 (es) * 2002-09-26 2005-10-05 Nihon Nohyaku Co Ltd Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos,
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
WO2006111549A1 (de) * 2005-04-21 2006-10-26 Boehringer Ingelheim International Gmbh Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
BRPI0710874A2 (pt) 2006-04-26 2012-02-14 Hoffmann La Roche compostos de tienopirimidina, processos de produção dos referidos compostos, composições farmacêuticas contendo os mesmos, kit, produto, e usos dos compostos
WO2007127175A2 (en) * 2006-04-26 2007-11-08 F. Hoffmann-La Roche Ag Pharmaceutical compounds
TW200801012A (en) * 2006-04-26 2008-01-01 Piramed Ltd Phosphoinositide 3-kinase inhibitor compounds and methods of use
EP2114950B1 (de) * 2006-12-07 2016-03-09 Genentech, Inc. Phosphoinositid-3-kinaseinhibitorverbindungen und anwendungsverfahren
AU2007329352B2 (en) * 2006-12-07 2013-01-17 F. Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
CA2705719C (en) * 2007-09-14 2016-10-11 Janssen Pharmaceutica N.V. Thieno-and furo-pyrimidine modulators of the histamine h4 receptor
ES2399774T3 (es) 2007-09-24 2013-04-03 Genentech, Inc. Compuestos de tiazolopirimidina inhibidores de PI3K y métodos de uso
JP5150728B2 (ja) 2007-10-19 2013-02-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピペリジノ−ジヒドロチエノピリミジン
EP2215093B1 (de) 2007-10-19 2011-12-14 Boehringer Ingelheim International GmbH Neue piperazino-dihydrothienopyrimidin-derivate
EP2205609B1 (de) 2007-10-19 2017-03-29 Boehringer Ingelheim International GmbH Heterocyclus-substituierte piperazino-dihydrothienopyrimidine
JP5348725B2 (ja) 2007-10-25 2013-11-20 ジェネンテック, インコーポレイテッド チエノピリミジン化合物の製造方法
GB0721095D0 (en) * 2007-10-26 2007-12-05 Piramed Ltd Pharmaceutical compounds
AU2008323628B2 (en) * 2007-11-15 2013-10-17 Ym Biosciences Australia Pty Ltd N-containing heterocyclic compounds
EP2405916B1 (de) 2009-03-12 2018-02-07 Genentech, Inc. Kombination von phosphoinositid 3-kinase inhibitor- verbindungen und chemiotherapeutischen mitteln für die behandlung von blutbildenden bösartigen tumoren
US8158625B2 (en) * 2009-05-27 2012-04-17 Genentech, Inc. Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
WO2010138589A1 (en) * 2009-05-27 2010-12-02 Genentech, Inc. Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
PH12012500709A1 (en) * 2009-10-12 2012-10-29 Hoffmann La Roche Combinations of a pi3k inhibitor and a mek inhibitor
BR112012026470A2 (pt) 2010-04-16 2016-08-09 Genentech Inc método para prever a sensibilidade de crescimento de células tumorais e para tratar um tumor em um paciente
US20140004209A1 (en) 2010-12-22 2014-01-02 Genentech, Inc. Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
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FR2988722B1 (fr) * 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
JP6077642B2 (ja) * 2012-04-10 2017-02-08 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合ピリミジン化合物、その調製法、中間体、組成物、及び使用
AR094873A1 (es) 2013-02-25 2015-09-02 Genentech Inc Métodos y composiciones para detectar y tratar mutantes de akt resistentes a fármacos
CN103242341B (zh) * 2013-04-19 2015-12-09 中国科学院广州生物医药与健康研究院 噻吩并2,4取代嘧啶类化合物及其药物组合物与应用
EP3053926B1 (de) * 2013-09-30 2018-08-08 Shanghai Yingli Pharmaceutical Co. Ltd. Kondensierte pyrimidinverbindung, zwischenprodukt, herstellungsverfahren dafür und zusammensetzung und anwendung davon
RU2545758C1 (ru) * 2014-03-20 2015-04-10 Общество с ограниченной ответственностью "Алион" Бициклические пиримидины или их фармацевтически приемлемые соли-активаторы антиоксидантной программы и их применение в качестве цитопротекторов
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US10646490B2 (en) 2015-03-02 2020-05-12 University Of Maryland, Baltimore County Thieno- and pyrrolopyrimidine analogues and prodrugs thereof as anticancer agents and methods of use thereof
US9434742B1 (en) * 2015-03-02 2016-09-06 University Of Maryland, Baltimore County Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
EP3324974B1 (de) * 2015-07-24 2022-06-08 University Of Louisville Research Foundation, Inc. Verbindungen, zusammensetzungen, verfahren zur behandlung von erkrankungen und verfahren zur zubereitung von verbindungen
DE102015012049A1 (de) * 2015-09-15 2017-03-16 Merck Patent Gmbh Verbindungen als ASIC-Inhibitoren und deren Verwendungen
US10696688B2 (en) 2015-11-23 2020-06-30 Council Of Scientific & Industrial Research Fused pyrimidines as isoform selective phosphoinositide-3-kinase-alpha inhibitors and process for preparation thereof
SG11201804901WA (en) 2015-12-22 2018-07-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
CN105820175B (zh) * 2016-04-13 2019-09-20 四川大学 一种噻吩并嘧啶类化合物及其制备方法和应用
CN107698603B (zh) 2016-08-09 2022-04-08 南京红云生物科技有限公司 噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用
GB201700814D0 (en) 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
CA3066939A1 (en) 2017-06-21 2018-12-27 SHY Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
WO2020132071A1 (en) 2018-12-19 2020-06-25 Shy Therapeutics. Llc Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease
EP3897651A4 (de) * 2018-12-21 2022-09-21 University of Notre Dame du Lac Entdeckung von inhibitoren von bd-oxidase zur behandlung mykobakterieller erkrankungen
MX2021009667A (es) 2019-02-13 2021-12-10 Ptc Therapeutics Inc Compuestos de tioeno[3,2-b] piridin-7-amina para tratar la disautonomía familiar.
US12398140B2 (en) 2019-02-13 2025-08-26 Ptc Therapeutics, Inc. Substituted pyrrolo [2,3-d]pyrimidines for treating familial dysautonomia
JP2024533264A (ja) * 2021-09-07 2024-09-12 ピーティーシー セラピューティクス, インコーポレイテッド 神経原性疾患を処置するための方法
CN115991716B (zh) * 2021-10-19 2025-10-17 中国药科大学 嘧啶并环类化合物及其衍生物、制备方法、药物组合物和应用

Also Published As

Publication number Publication date
FR4321M (de) 1966-08-01
US3475429A (en) 1969-10-28
FR1603313A (en) 1971-04-05
GB1057612A (en) 1967-02-01
DE1470356A1 (de) 1970-04-30

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