CH393638A - Procédé de préparation d'un nouvel antibiotique - Google Patents
Procédé de préparation d'un nouvel antibiotiqueInfo
- Publication number
- CH393638A CH393638A CH111560A CH111560A CH393638A CH 393638 A CH393638 A CH 393638A CH 111560 A CH111560 A CH 111560A CH 111560 A CH111560 A CH 111560A CH 393638 A CH393638 A CH 393638A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- chalcomycin
- medium
- fermentation
- organism
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- IJESDYFOSZHYNR-UHFFFAOYSA-N chalcomycin Natural products COC1CC(C)OC(OC2CCC(C)(O)C(=O)C=CC3OC3C(COC4OC(C)C(O)C(OC)C4OC)C(C)OC(=O)C=CC2)C1O IJESDYFOSZHYNR-UHFFFAOYSA-N 0.000 claims description 79
- KLGADJPDTCIJLO-LJUCOGSUSA-N Chalcomycin Chemical compound O[C@@H]1[C@@H](OC)C[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)/C=C/C(=O)O[C@H](C)[C@@H](CO[C@H]2[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O2)OC)[C@H]2O[C@@H]2/C=C/C(=O)[C@@](C)(O)C[C@@H]1C KLGADJPDTCIJLO-LJUCOGSUSA-N 0.000 claims description 78
- 239000000203 mixture Substances 0.000 claims description 41
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 24
- 235000015097 nutrients Nutrition 0.000 claims description 22
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 238000011534 incubation Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims description 6
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- 238000000855 fermentation Methods 0.000 description 40
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- 239000000243 solution Substances 0.000 description 33
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- 229920001817 Agar Polymers 0.000 description 26
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 21
- 239000000047 product Substances 0.000 description 18
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- OZKXLOZHHUHGNV-UHFFFAOYSA-N Viomycin Natural products NCCCC(N)CC(=O)NC1CNC(=O)C(=CNC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC1=O)C2CC(O)NC(=N)N2 OZKXLOZHHUHGNV-UHFFFAOYSA-N 0.000 description 1
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- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- DLRVVLDZNNYCBX-ZZFZYMBESA-N beta-melibiose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 DLRVVLDZNNYCBX-ZZFZYMBESA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- DNZWLJIKNWYXJP-UHFFFAOYSA-N butan-1-ol;propan-2-one Chemical compound CC(C)=O.CCCCO DNZWLJIKNWYXJP-UHFFFAOYSA-N 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
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- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/50—Streptomyces bikiniensis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/891—Streptomyces bikiniensia
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US790689A US3065137A (en) | 1959-02-02 | 1959-02-02 | Chalcomycin and its fermentative production |
| FR817370A FR1467002A (fr) | 1959-02-02 | 1960-02-02 | Fabrication d'un antibiotique appelé |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH393638A true CH393638A (fr) | 1965-06-15 |
Family
ID=25151474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH111560A CH393638A (fr) | 1959-02-02 | 1960-02-02 | Procédé de préparation d'un nouvel antibiotique |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3065137A (en, 2012) |
| AT (1) | AT225353B (en, 2012) |
| BE (1) | BE587213A (en, 2012) |
| BR (1) | BR6016635D0 (en, 2012) |
| CH (1) | CH393638A (en, 2012) |
| DK (1) | DK95263C (en, 2012) |
| ES (1) | ES255258A1 (en, 2012) |
| FR (2) | FR1467002A (en, 2012) |
| GB (1) | GB875011A (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003260062A1 (en) * | 2002-08-21 | 2004-03-11 | Kosan Biosciences, Inc. | Recombinant chalcomycin polyketide synthase and modifying genes |
| DE10248453A1 (de) * | 2002-10-17 | 2004-05-13 | Biofrontera Discovery Gmbh | Chalcomycin-Derivate |
| US20040132055A1 (en) * | 2002-10-24 | 2004-07-08 | Leonard Katz | Recombinant chalcomycin polyketide synthase and modifying genes |
| CN101624413B (zh) * | 2008-07-11 | 2012-09-26 | 中国科学院海洋研究所 | 一种查尔霉素化合物及其制备和应用 |
-
1959
- 1959-02-02 US US790689A patent/US3065137A/en not_active Expired - Lifetime
-
1960
- 1960-01-25 ES ES0255258A patent/ES255258A1/es not_active Expired
- 1960-01-29 AT AT70560A patent/AT225353B/de active
- 1960-02-01 BR BR116635/60A patent/BR6016635D0/pt unknown
- 1960-02-01 DK DK37560AA patent/DK95263C/da active
- 1960-02-02 BE BE587213A patent/BE587213A/fr unknown
- 1960-02-02 CH CH111560A patent/CH393638A/fr unknown
- 1960-02-02 GB GB3743/60A patent/GB875011A/en not_active Expired
- 1960-02-02 FR FR817370A patent/FR1467002A/fr not_active Expired
- 1960-08-31 FR FR837389A patent/FR577M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR577M (en, 2012) | 1961-06-05 |
| FR1467002A (fr) | 1967-01-27 |
| BE587213A (fr) | 1960-08-02 |
| ES255258A1 (es) | 1960-09-16 |
| US3065137A (en) | 1962-11-20 |
| AT225353B (de) | 1963-01-10 |
| GB875011A (en) | 1961-08-16 |
| DK95263C (da) | 1963-02-04 |
| BR6016635D0 (pt) | 1973-05-24 |
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