CH311580A - Process for the preparation of a basic substituted fatty acid (2-halogen-6-methyl-anilide). - Google Patents
Process for the preparation of a basic substituted fatty acid (2-halogen-6-methyl-anilide).Info
- Publication number
- CH311580A CH311580A CH311580DA CH311580A CH 311580 A CH311580 A CH 311580A CH 311580D A CH311580D A CH 311580DA CH 311580 A CH311580 A CH 311580A
- Authority
- CH
- Switzerland
- Prior art keywords
- anilide
- methyl
- halogen
- fatty acid
- preparation
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Description
Verfahren zur Herstellung eines basisch substituierten Fettsäure- (2-halogen-6-methyl-anilids). Gegenstand des vorliegenden Patentes bil det ein Verfahren zur Herstellung eines neuen basisch substituierten Fettsäure-(2-halogen-6- inethyl-anilids), welches dadurch gekennzeich net ist, dass man eine Verbindung der Formel
EMI0001.0006
mit Piperidin umsetzt. Die Umsetzung kann in An- oder Abwesenheit von Lösungs- bzw.
Verdünnungsmitteln und Anlagerungskata- lysatoren erfolgen. Vorzugsweise wird wegen der Lei.ehtflüehtigkeit des Piperidins unter Druck gearbeitet. Als Anlagerungskatalysato- ren benützt man vorteilhaft. quaternäre Am- inoniumbasen, wie z. B. Trimet.hylbenzvIammo- niumhydroxyd.
Das so erhaltene ss-Piperidino-p.ropionsäure- (2-ehlor-6-methyl-anilid) bildet ein farbloses Kristallpulver; dessen Hydrochlorid schmilzt. bei 181,5-183,5 . Das neue Anilid soll als Lokalanästhetikum und als Zwischenprodukt zur Herstellung weiterer Derivate Verwen- dung finden.
<I>Beispiel:</I> Ein, Gemisch von 20 Gewichtsteilen Aeryl- säure-(2-chlor-6-methyl-anilid) 17 Gewichts- teilen Piperidin und einigen Tropfen Trime- thylbenzylammoniumhydroxyd wird im Auto klaven während 20 Stunden auf l45 erhitzt. Nach dem Erkalten wird durch die Reaktions mischung Wasserdampf zwecks Entfernung flüchtiger Anteile geleitet.
Anschliessend wird verdampft und der Rückstand aus Petroläther umkristallisiert. Man erhält so das ss-Piperi- dino - propionsäure- (2 - chlor - 6 -methyl-anilid ) als farbloses Kristallpulver.
Process for the preparation of a basic substituted fatty acid (2-halogen-6-methyl-anilide). The subject of the present patent bil det a process for the preparation of a new basic substituted fatty acid (2-halogen-6-ynethyl-anilide), which is characterized in that a compound of the formula
EMI0001.0006
Reacts with piperidine. The implementation can take place in the presence or absence of solution or
Diluents and addition catalysts take place. Because of the volatility of piperidine, it is preferable to work under pressure. It is advantageous to use the addition catalysts. quaternary ammonium bases, such as. B. trimethylbenzene ammonium hydroxide.
The β-piperidino-propionic acid (2-chloro-6-methyl-anilide) obtained in this way forms a colorless crystal powder; its hydrochloride melts. at 181.5-183.5. The new anilide is to be used as a local anesthetic and as an intermediate for the manufacture of other derivatives.
<I> Example: </I> A mixture of 20 parts by weight of aerylic acid (2-chloro-6-methyl-anilide), 17 parts by weight of piperidine and a few drops of trimethylbenzylammonium hydroxide is heated to 145 in the car for 20 hours heated. After cooling, water vapor is passed through the reaction mixture to remove volatile components.
It is then evaporated and the residue is recrystallized from petroleum ether. The β-piperidino-propionic acid (2-chloro-6-methyl anilide) is obtained in this way as a colorless crystal powder.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH311580T | 1952-02-25 | ||
| CH306512T | 1952-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH311580A true CH311580A (en) | 1955-11-30 |
Family
ID=25735179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH311580D CH311580A (en) | 1952-02-25 | 1952-02-25 | Process for the preparation of a basic substituted fatty acid (2-halogen-6-methyl-anilide). |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH311580A (en) |
-
1952
- 1952-02-25 CH CH311580D patent/CH311580A/en unknown
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