CH307876A - Process for the preparation of a complex iron salt of isonicotinic acid hydrazide. - Google Patents

Process for the preparation of a complex iron salt of isonicotinic acid hydrazide.

Info

Publication number
CH307876A
CH307876A CH307876DA CH307876A CH 307876 A CH307876 A CH 307876A CH 307876D A CH307876D A CH 307876DA CH 307876 A CH307876 A CH 307876A
Authority
CH
Switzerland
Prior art keywords
acid hydrazide
iron salt
preparation
isonicotinic acid
complex iron
Prior art date
Application number
Other languages
German (de)
Inventor
Schweizerhall Chemische Fabrik
Original Assignee
Schweizerhall Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schweizerhall Chem Fab filed Critical Schweizerhall Chem Fab
Publication of CH307876A publication Critical patent/CH307876A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

  

  <B>Verfahren zur Herstellung eines komplexen Eisensalzes von</B>     Isonicotinsäurehydrazid.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Herstellung eines neuen  komplexen Eisensalzes des     Isonicotinsäure-          hydrazids,    dem mutmasslich die folgende For  mel zukommt:  
EMI0001.0004     
    Das Verfahren gemäss der vorliegenden  Erfindung ist dadurch     gekennzeichnet,    dass       Pyridin-4-earbonsäurehydrazid,    vorzugsweise  in wässeriger Lösung, mit     Ferrosulfat    zur  Umsetzung gebracht wird.  



  Die neue Verbindung besitzt wertvolle  therapeutische Eigenschaften; sie ist insbeson  dere gegen Tuberkulose wirksam und soll des  halb als Heilmittel verwendet werden.  



  Die Umsetzung zwischen den Reaktions  komponenten wird     zweckmässigerweise    so  durchgeführt, dass eine wässerige Lösung des       Ferrosulfats    einer wässerigen Lösung von       Pyridin-4-carbonsäurehydrazid    bei Raumtem  peratur zugesetzt wird. Es erfolgt dabei     au--          genblicklich    Ausfällung eines bräunlichen  Niederschlages.

      <I>Beispiel:</I>  Einer wässerigen     Lösung    von 14 Gewichts  teilen     Pyridin-4-carbonsäurehydrazid    in 50       Volumteilen    Wasser wird eine Lösung von  <B>27,8</B>     Gewichtsteilen        Perrosulfat    in 150     Volum-          teilen    Wasser bei Raumtemperatur zugesetzt.  Es fällt nach     kurzer    Zeit ein bräunlicher kri  stalliner Niederschlag des komplexen Eisen  salzes aus, das     abfiltriert,    mit Wasser gewa  schen     lind    getrocknet     dvird.  



  <B> Process for the preparation of a complex iron salt from </B> isonicotinic acid hydrazide. The present invention relates to a process for the preparation of a new complex iron salt of isonicotinic acid hydrazide, which presumably has the following formula:
EMI0001.0004
    The process according to the present invention is characterized in that pyridine-4-carboxylic acid hydrazide, preferably in aqueous solution, is reacted with ferrous sulfate.



  The new compound has valuable therapeutic properties; it is particularly effective against tuberculosis and should therefore be used as a remedy.



  The reaction between the reaction components is expediently carried out in such a way that an aqueous solution of ferrous sulfate is added to an aqueous solution of pyridine-4-carboxylic acid hydrazide at room temperature. A brownish precipitate immediately precipitates.

      <I> Example: </I> An aqueous solution of 14 parts by weight of pyridine-4-carboxylic acid hydrazide in 50 parts by volume of water is added to a solution of 27.8 parts by weight of perrosulfate in 150 parts by volume of water at room temperature . After a short time, a brownish, crystalline precipitate of the complex iron salt separates out, which is filtered off, washed with water and dried.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung. eines kom plexen Eisensalzes von Isonicotinsäurehydra- zid, dadurch gekennzeichnet, dass Pyridin-4- carbonsäurehydrazyd mit Ferrosulfat zur Um setzung gebracht wird. Das erhaltene Komplexsalz ist eine bräun lich gefärbte, kristalline Substanz, die als Heilmittel verwendet werden soll. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass die Umsetzung in wäs seriger Lösung durchgeführt wird. PATENT CLAIM: Method of production. of a complex iron salt of isonicotinic acid hydrazide, characterized in that pyridine-4-carboxylic acid hydrazide is reacted with ferrous sulfate. The complex salt obtained is a brownish colored, crystalline substance to be used as a remedy. SUBCLAIM: Process according to claim, characterized in that the conversion is carried out in an aqueous solution.
CH307876D 1952-02-25 1952-02-25 Process for the preparation of a complex iron salt of isonicotinic acid hydrazide. CH307876A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH307876T 1952-02-25
CH304881T 1952-02-25

Publications (1)

Publication Number Publication Date
CH307876A true CH307876A (en) 1955-06-15

Family

ID=25734890

Family Applications (1)

Application Number Title Priority Date Filing Date
CH307876D CH307876A (en) 1952-02-25 1952-02-25 Process for the preparation of a complex iron salt of isonicotinic acid hydrazide.

Country Status (1)

Country Link
CH (1) CH307876A (en)

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