CH299247A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH299247A
CH299247A CH299247DA CH299247A CH 299247 A CH299247 A CH 299247A CH 299247D A CH299247D A CH 299247DA CH 299247 A CH299247 A CH 299247A
Authority
CH
Switzerland
Prior art keywords
bis
quaternary ammonium
preparation
aminoalkoxy
alkane
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH299247A publication Critical patent/CH299247A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      Verfahren    zur Herstellung einer     quaternären        Ammoniumverbindung:     eines     Bis-aminoalkoxy-alkans.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     quaternären          Ammoniumverbindung    eines     Bis-aminoalkoxy-          alkans.    Das Verfahren ist dadurch gekenn  zeichnet, dass man auf ein     Mol        1,12-Bis-(ss-          brom-äthoxy)-dodekan    zwei     Mol        Dimethyl-          butylamin    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,12-          Bis-        [ss-(dimethyl        -butyl    -     ammonium)        -äthoxy    ]     -          dodekan-dibromid,    schmilzt bei 138-142 .  



  Sie soll therapeutische Verwendung finden.         Beispiel:            .1,16    Teile reines     1,12-Bis-(ss-brom-äthoxy)-          dodekan,    20     Volinnteile    trockenes Aceton und  2,5 Teile reines     Dimethyl-butylamin    werden  im     Einsehmelzrohr    14 Stunden auf 90-100   erhitzt, nach Erkalten wird abgesaugt und  das erhaltene     1,12-Bis-        [ss-    (dimethyl-biityl-         ammoniiun)

          -äthoxy]        -dodekan-dibromid    aus       Butanon        +    wenig     abs.    Methanol gereinigt,  indem das Salz in möglichst wenig heissem  Methanol gelöst und darauf so viel heisses       Butanon    zugefügt wird, dass in der Hitze  noch alles in Lösung bleibt.  



  Das     umkristallisierte    Produkt schmilzt bei  138-142 .



      Process for the preparation of a quaternary ammonium compound: a bis-aminoalkoxy-alkane. The present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane. The process is characterized in that two moles of dimethylbutylamine are allowed to act on one mole of 1,12-bis (ss-bromo-ethoxy) -dodecane.



  The new compound obtained, the 1,12-bis- [ss- (dimethyl-butyl-ammonium) -ethoxy] -dodecane dibromide, melts at 138-142.



  It should find therapeutic use. Example: 1.16 parts of pure 1,12-bis- (ss-bromo-ethoxy) -dodecane, 20 parts by volume of dry acetone and 2.5 parts of pure dimethyl-butylamine are heated to 90-100 for 14 hours in a single melt tube, after cooling is suctioned off and the 1,12-bis- [ss- (dimethyl-biityl- ammonium) obtained

          ethoxy] dodecane dibromide from butanone + little abs. Methanol is purified by dissolving the salt in as little hot methanol as possible and then adding so much hot butanone that everything remains in solution in the heat.



  The recrystallized product melts at 138-142.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- nären Ammoniumverbindung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol 1,12-Bis-(ss-brom-äthoxy)- dodekan zwei Mol Dimethyl-butylamin ein wirken lässt. PATENT CLAIM: A process for the production of a quaternary ammonium compound of a bis-aminoalkoxyalkane, characterized in that two moles of dimethylbutylamine are allowed to act on one mole of 1,12-bis (ss-bromo-ethoxy) dodecane . Die erhaltene neue Verbindung, das 7.,12- Bis- [ss- (dimethyl -butyl - ammonium) -äthox-y] - dodekan-dibromid, schmilzt bei 138-142 . The new compound obtained, the 7th, 12-bis- [ss- (dimethyl-butyl-ammonium) -ethox-y] -dodecane dibromide, melts at 138-142.
CH299247D 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH299247A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH299247T 1951-09-20
CH291680T 1952-04-21

Publications (1)

Publication Number Publication Date
CH299247A true CH299247A (en) 1954-05-31

Family

ID=25733127

Family Applications (1)

Application Number Title Priority Date Filing Date
CH299247D CH299247A (en) 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH299247A (en)

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