CH299235A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Info

Publication number
CH299235A
CH299235A CH299235DA CH299235A CH 299235 A CH299235 A CH 299235A CH 299235D A CH299235D A CH 299235DA CH 299235 A CH299235 A CH 299235A
Authority
CH
Switzerland
Prior art keywords
bis
quaternary ammonium
alkane
ammonium compound
aminoalkoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH299235A publication Critical patent/CH299235A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung einer     quaternären        Ammoniumverhindung     eines     Bis-aminoalkoxy-alkans.            Gegenstand    vorliegenden Patentes ist ein  Verfahren     mir    Herstellung einer     quaternären          Ammoniumverbindung    eines     Bis-aminoalkoxy-          alkans.    Das Verfahren ist dadurch gekenn  zeichnet, dass man auf ein     Mol        1,12-Bis-(,8-          dimethylamino-äthoxy)

  -dodelcan    zwei     Mol        141e-          thyljodid    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,12-          Bis-        (,ss-trimethyl-ammoniuin-äthoxy)        -dodekan-          dijodid,    schmilzt bei 163 .  



  Sie soll therapeutische Verwendung finden.  <I>Beispiel:</I>  17,2 Teile 1,12 - Bis - (,8 -     dimethylamino-          äthoxy        )-dodekan    werden     finit    80 Teilen     trok-          kenem    Aceton und 18 Teilen     Methyljodid    14  Stunden     in    einem Wasserbad von 50-60  er  wärmt.

   Nach Erkalten wird abgesaugt und  das erhaltene     1,12-Bis-    (p-trimethylammonium-         äthoxy)    -     dodekan    -     dijodid        gewünschtenfalls     durch     Umliristallisieren    aus     Butanon    + wenig       abs.    Methanol     gereinigt,    indem das     Salz    in  möglichst wenig heissem Methanol gelöst und  darauf so viel heisses     Butanon    zugefügt wird,  dass in der Hitze noch alles gelöst bleibt.  



  Das     umkristallisierte    Produkt schmilzt bei  163 .



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. The subject of the present patent is a process with the production of a quaternary ammonium compound of a bis-aminoalkoxyalkane. The process is characterized in that one mole of 1,12-bis (, 8-dimethylamino-ethoxy)

  -dodelcan allows two moles of 141-ethyl iodide to act.



  The new compound obtained, the 1,12-bis- (, ss-trimethyl-ammoniuin-ethoxy) -dodecane diiodide, melts at 163.



  It should find therapeutic use. <I> Example: </I> 17.2 parts of 1.12 - bis - (, 8 - dimethylaminoethoxy) dodecane are finely 80 parts of dry acetone and 18 parts of methyl iodide in a water bath of 50-60 hours he warms.

   After cooling, the product is filtered off with suction and the 1,12-bis- (p-trimethylammonium-ethoxy) -dodecane-diiodide obtained, if desired, by crystallization from butanone + a little abs. Methanol is purified by dissolving the salt in as little hot methanol as possible and then adding so much hot butanone that everything remains dissolved in the heat.



  The recrystallized product melts at 163.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- nären Ammoniumverbindung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol 1,12-Bis-(ss-dimethylamino- äthoxy)-dodekan zwei 112o1 Methyljodid ein wirken lä.sst. Die erhaltene neue Verbindung, das 1, PATENT CLAIM: Process for the production of a quaternary ammonium compound of a bis-amino-alkoxy-alkane, characterized in that two 112o1 methyl iodide are allowed to act on one mole of 1,12-bis (ss-dimethylamino-ethoxy) -dodecane . The received new connection, the 1, 12- Bis- (ss-trimethylammonium - äthoxy) -dodekan- dijodid, schmilzt bei 163 . 12-bis- (ss-trimethylammonium-ethoxy) -dodecane diiodide, melts at 163.
CH299235D 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH299235A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH299235T 1951-09-20
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH299235A true CH299235A (en) 1954-05-31

Family

ID=25733012

Family Applications (1)

Application Number Title Priority Date Filing Date
CH299235D CH299235A (en) 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH299235A (en)

Similar Documents

Publication Publication Date Title
CH299235A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299231A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299244A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299241A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299236A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299240A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299239A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293937A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299234A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299238A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299232A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293939A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299242A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299237A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293933A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH298054A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299233A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293932A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293942A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293934A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293944A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH293940A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH312530A (en) Process for making a pyridazone.
CH293936A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH299243A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.