CH293939A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH293939A
CH293939A CH293939DA CH293939A CH 293939 A CH293939 A CH 293939A CH 293939D A CH293939D A CH 293939DA CH 293939 A CH293939 A CH 293939A
Authority
CH
Switzerland
Prior art keywords
bis
quaternary ammonium
ammonium compound
preparation
aminoalkoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH293939A publication Critical patent/CH293939A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      verfahren        zur        Herstellung    einer     quaternären        Ammoniumverbindung     <B>eines</B>     Bis-aminoalkogy-alkans.       Gegenstand vorliegenden Patentes ist, ein  Verfahren zur Herstellung einer     quaternären          Ammoniumverbindung    eines     Bis-aminoa.lkoxy-          alkans.    Das Verfahren ist.

   dadurch gekenn  zeichnet, dass man auf ein     Mol        1,6-Bis-(ä-di-          äthylamino-butoxy)-hexan    zwei     Mol        Äthyl-          jodid    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,6-          Bis-        (b-triä.thylammonium-butoxy        )-hexan-di-          jodid,    schmilzt bei 99 . Sie soll     therapeutische     Verwendung finden.  



  <I>Beispiel:</I>  18,6 Teile     1,6-Bis-        (d-diä.thyIamino-butoxv)-          hexan    werden mit. 80 Teilen trockenem Aceton  und 19 Teilen     Äthyljodid        1..1    Stunden in  einem     Wasserbad    von     .50    bis 60  erwärmt.

         Naeli    Erkalten wird abgesaugt     und    das erhal  tene     1.6-Bis-(o-ti#iäthylammonium-butoxy    )-         hexan-dijodid        gewünschtenfalls    durch Um  kristallisieren aus     Butanon    + wenig     abs.     Methanol gereinigt, indem das Salz in mög  lichst wenig heissem Methanol gelöst und  darauf so viel heisses     Butanon        zugefügt    wird,  dass in der Hitze noch alles gelöst bleibt. Das  umkristallisierte Produkt schmilzt bei 99 .



      Process for the production of a quaternary ammonium compound <B> of </B> a bis-aminoalkogyalkane. The subject of the present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoa.lkoxyalkane. The procedure is.

   characterized in that two moles of ethyl iodide are allowed to act on one mole of 1,6-bis (ä-diethylamino-butoxy) hexane.



  The new compound obtained, 1,6-bis- (b-triä.thylammonium-butoxy) -hexane-diiodide, melts at 99. It should find therapeutic use.



  <I> Example: </I> 18.6 parts of 1,6-bis (d-diä.thyIamino-butoxv) - hexane are mixed with. 80 parts of dry acetone and 19 parts of ethyl iodide for 1..1 hours in a water bath from .50 to 60 heated.

         Naeli cooling is filtered off with suction and the 1,6-bis- (o-ti # iäthylammonium-butoxy) -hexane diiodide obtained, if desired by crystallizing from butanone + a little abs. Methanol is purified by dissolving the salt in as little hot methanol as possible and then adding so much hot butanone that everything remains dissolved in the heat. The recrystallized product melts at 99.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- nären Ammoniumverbindung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol 1,6-Bis- (8-diäthylamino- butoxy)-hexanzwei Mol Äthyljodid einwirken lässt. Die erhaltene neue Verbindung, das 1,6- Bis- (8-triäthylammonium-butoxy) PATENT CLAIM: Process for the production of a quaternary ammonium compound of a bis-aminoalkoxyalkane, characterized in that two moles of ethyl iodide are allowed to act on one mole of 1,6-bis- (8-diethylamino-butoxy) -hexane. The new compound obtained, the 1,6-bis (8-triethylammonium-butoxy) -hexan-di- jodid, schmilzt bei 99 . -hexane-di- iodide, melts at 99.
CH293939D 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH293939A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH293939T 1949-12-07
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH293939A true CH293939A (en) 1953-10-15

Family

ID=25732999

Family Applications (1)

Application Number Title Priority Date Filing Date
CH293939D CH293939A (en) 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH293939A (en)

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