CH293932A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH293932A
CH293932A CH293932DA CH293932A CH 293932 A CH293932 A CH 293932A CH 293932D A CH293932D A CH 293932DA CH 293932 A CH293932 A CH 293932A
Authority
CH
Switzerland
Prior art keywords
bis
quaternary ammonium
alkane
ammonium compound
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH293932A publication Critical patent/CH293932A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren     zur    Herstellung     einer        quaternären        Ammoniumverbindung    eines       Bis-aminoalkoxy-alkans.            1;egenstand    vorliegenden Patentes ist ein  Verfahren zur     Herstellung    einer     quaternären          Ammoniumverbindung    eines     Bis-aminoalkoxy-          alkans.        I)as    Verfahren     ist.    dadurch gekenn  zeichnet,     dali    man auf ein     Mol        1,10-Bis-(;

  )-          diäthylamino-propoxy)-dekan    zwei     Mol    Äthyl.       ;jodid    einwirken lässt.  



  Die erhaltene neue Verbindung, das 1.,1.0  Bis -     (,-triäthylammonium-pr        opoxy)        -,dekan-di-          jodid,    schmilzt. bei 9(1 bis 91 . Sie soll thera  peutische Verwendung finden.  



  <I>Beispiel:</I>       '?0    Teile     1,10-Bis-        (,-diäthylamino-propoxy    )  dekan werden mit 80 Teilen     trockenem    Ace  ton und 19 Teilen     :1thyljodid    1 4 Stunden in  einem     Wasserbad    von<B>50</B> bis 60  erwärmt.

    Nach Erkalten wird abgesaugt und das erhal  tene 7,10-Bis-(,-t.riäthylammonium-propoxy)-         dekan-dijodid        gewünschtenfalls    durch Um  kristallisieren aus     Butanon    und wenig     abs.     Methanol     gereinigt,    indem das Salz in mög  lichst. wenig heissem Methanol gelöst und  darauf so viel heisses     Butanon    zugefügt wird,       da.ss    in der Hitze noch alles gelöst bleibt.  Das     umkristallisierte    Produkt     schmilzt    bei 90  bis 91 .



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. 1; subject of the present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane. I) the procedure is. characterized in that one mole of 1,10-bis- (;

  ) - diethylamino-propoxy) -dekan two moles of ethyl. ; lets iodide act.



  The new compound obtained, the 1st, 1.0 bis- (, -triäthylammonium-pr opoxy) -, decane di- iodide, melts. at 9 (1 to 91. It should be used therapeutically.



  <I> Example: </I> '? 0 parts of 1,10-bis- (, -diethylamino-propoxy) decane are mixed with 80 parts of dry acetone and 19 parts: 1-ethyl iodide for 1 4 hours in a water bath of <B> 50 </B> heated to 60.

    After cooling, the product is filtered off with suction and the 7,10-bis (, - t.riäthylammonium-propoxy) -dekan-diiodide obtained, if desired, crystallize from butanone and a little abs. Methanol purified by adding the salt in as possible. a little hot methanol and then so much hot butanone is added that everything remains dissolved in the heat. The recrystallized product melts at 90 to 91.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- nären Ammoniumverbindung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, da.ss man auf ein Mol 1,10-Bis- (7-diäthylamino- propoxy)-dekan zwei Mol Äthyljodid einwir ken lässt. Claim: Process for the production of a quaternary ammonium compound of a bis-amino-alkoxy-alkane, characterized in that two moles of ethyl iodide are allowed to act on one mole of 1,10-bis (7-diethylamino-propoxy) decane . Die erhaltene neue Verbindung, das 1,10- Bis -(,-triäthylammonium-propoxy )-dekan-di- jodid, schmilzt bei 90 bis 91 . The new compound obtained, the 1,10-bis (, - triethylammonium-propoxy) -dekan-di-iodid, melts at 90 to 91.
CH293932D 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH293932A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH293932T 1949-12-07
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH293932A true CH293932A (en) 1953-10-15

Family

ID=25732992

Family Applications (1)

Application Number Title Priority Date Filing Date
CH293932D CH293932A (en) 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH293932A (en)

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