CH299233A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

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Publication number
CH299233A
CH299233A CH299233DA CH299233A CH 299233 A CH299233 A CH 299233A CH 299233D A CH299233D A CH 299233DA CH 299233 A CH299233 A CH 299233A
Authority
CH
Switzerland
Prior art keywords
bis
quaternary ammonium
preparation
ammonium compound
aminoalkoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH299233A publication Critical patent/CH299233A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren     zur    Herstellung einer     quaternären        Ammoniumverbindung     eines     Bis-aminoalkoxy-alkans.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     quaternären          Ammoniumverbindung    eines     Bis-aminoalkoxy-          alkans.    Das Verfahren ist dadurch gekenn  zeichnet, dass man auf ein     Mol        1,11-Bis-[ss-          (butyl-rnethyl-amino)-äthoxy]-undekan    zwei       Mol        Methylbromid    einwirken lässt.  



  Die erhaltene neue Verbindung, das 1,11  Bis -     [/3-        (dimethyl-butyl,        ammonium)    -     äthoxy]        -          undekan-dibromid,    schmilzt bei 127-128 .  



  Sie soll therapeutische Verwendung finden.  <I>Beispiel:</I>  20,7 Teile 1,11- Bis -     [ss    -     (butyl    -     methyl-          amino)-äthoxy]-undekan    werden mit 80 Tei  len trockenem Aceton und 12 Teilen     Methyl-          bromid    14 Stunden im     Einschmelzrohr    in  einem Wasserbad von 50-60  erwärmt.

   Nach  Erkalten     wird    abgesaugt und das erhaltene    1.,11<I>- Bis-</I>     [ss    -     (dimethyl    -     butyl    -     ammonium)-          äthoxy]        -undekan-dibromid        gewünschtenfalls     durch     Umkristallisieren    aus     Butanon        -I-    wenig       abs.    Methanol gereinigt, indem das Salz in  möglichst wenig heissem Methanol gelöst und  darauf so viel heisses     Bittanon    zugefügt wird,  dass     in    der Hitze noch alles gelöst bleibt.  



  Das umkristallisierte Produkt schmilzt bei       1.27-128 .    .



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane. The present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane. The process is characterized in that two moles of methyl bromide are allowed to act on one mole of 1,11-bis [ss- (butyl-methyl-amino) -ethoxy] -undecane.



  The new compound obtained, the 1.11 bis [/ 3- (dimethyl-butyl, ammonium) -ethoxy] -undecane dibromide, melts at 127-128.



  It should find therapeutic use. <I> Example: </I> 20.7 parts of 1,11 bis - [ss - (butyl - methylamino) ethoxy] undecane are mixed with 80 parts of dry acetone and 12 parts of methyl bromide for 14 hours Melting tube heated in a water bath of 50-60.

   After cooling, it is filtered off with suction and the obtained 1., 11 <I> - bis- </I> [ss - (dimethyl - butyl - ammonium) - ethoxy] undecanedibromide, if desired, by recrystallization from butanone -I- a little abs. Methanol is purified by dissolving the salt in as little hot methanol as possible and then adding so much hot bitanone that everything remains dissolved in the heat.



  The recrystallized product melts at 1.27-128. .

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- nären Ammoniumverbindung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol. 1,11-Bis-[ss-(butyl-methyl- i amino) --Lindekan zwei Mol Metliylbro- -äthoxy] mid einwirken lässt. PATENT CLAIM: A process for the production of a quaternary ammonium compound of a bis-aminoalkoxyalkane, characterized in that one mole of 1,11-bis- [ss- (butyl-methyl- iamino) -indecane is used for two moles Metliylbro- ethoxy] mid can act. Die erhaltene neue Verbindung, das 1,11- Bis- [ss- (dimethyl -butyl - ammonium) -äthoxy] - undekan-dibromid, schmilzt bei 127-128 . The new compound obtained, the 1,11-bis- [ss- (dimethyl-butyl-ammonium) -ethoxy] -undecane dibromide, melts at 127-128.
CH299233D 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH299233A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH299233T 1951-09-20
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH299233A true CH299233A (en) 1954-05-31

Family

ID=25733010

Family Applications (1)

Application Number Title Priority Date Filing Date
CH299233D CH299233A (en) 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH299233A (en)

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