CH293943A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Info

Publication number
CH293943A
CH293943A CH293943DA CH293943A CH 293943 A CH293943 A CH 293943A CH 293943D A CH293943D A CH 293943DA CH 293943 A CH293943 A CH 293943A
Authority
CH
Switzerland
Prior art keywords
sep
bis
preparation
alkane
aminoalkoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH293943A publication Critical patent/CH293943A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung einer     quaternären        Ammoniumverhindung     eines     Bis-aminoalkoxy-alkans.     
EMI0001.0004     
  
    Gelenstand <SEP> vorliegenden <SEP> Patentes <SEP> ist <SEP> ein
<tb>  Verfahren <SEP> zur <SEP> I3erstellume <SEP> einer <SEP> quaternären
<tb>  Arnnioriiumverbindung <SEP> eines <SEP> Bis-aniinoalkoxy  alkans. <SEP> Das <SEP> Verfahren <SEP> ist. <SEP> dadureh <SEP> gekenn  zeiehnet, <SEP> dass <SEP> man <SEP> auf <SEP> ein <SEP> Mol <SEP> 1,70-Bis-[/3  (metllyl-butwl-amino)-ä.tlroxy]-dekan <SEP> zwei <SEP> Mol
<tb>  :Vlethylbronrid <SEP> einwirken <SEP> lässt.
<tb>  



  Die <SEP> erhaltene <SEP> neue <SEP> Verbindung, <SEP> das <SEP> <B><I>1,10-</I></B>
<tb>  1)i- <SEP> [ss-(dimetliyl <SEP> -butyl <SEP> -ammoniriin <SEP> )-ä.thoxv-i <SEP>   dekan-dibromid, <SEP> schmilzt <SEP> bei <SEP> 1.48 <SEP> bis <SEP> 149 . <SEP> Sie
<tb>  soll <SEP> therapeutisehe <SEP> Verwendung <SEP> finden.
<tb>  



  <I>Beispiel:</I>
<tb>  20 <SEP> Teile <SEP> 1,10-Bis-[ss-(methyl-butyl-arnino)  äth.oxyl-clekan <SEP> werden <SEP> mit. <SEP> 80 <SEP> Teilen <SEP> trocke  nem <SEP> Aeetorr <SEP> und <SEP> 1\? <SEP> Teilen <SEP> Methylbromid <SEP> 74
<tb>  Stunden <SEP> im <SEP> Einschmelzrohr <SEP> in <SEP> einem <SEP> Was  serbad <SEP> von <SEP> 50 <SEP> bis <SEP> 60  <SEP> erwärmt.

   <SEP> Nach <SEP> Erkalten
<tb>  wird <SEP> abgesaugt <SEP> und <SEP> das <SEP> erhaltene <SEP> 1,10-Di-[ss-            (dimethyl    -     butyl    -     ammonium)-        äthoxy]    -     dekan-          dihromid        gewünsehtenfalls        dureh        Umkristalli-          sieren    aus     Butanon    + wenig     abs.    Methanol       (Yereinimt,    indem das Salz in möglichst wenig  heissem Methanol gelöst und darauf so viel.

    heisses     Butanon    zugefügt wird,     dass    in der  Hitze noch alles gelöst bleibt. Das umkristal  lisierte Produkt schmilzt bei 148     bis        149 .  



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
EMI0001.0004
  
    Gelenstand <SEP> present <SEP> patent <SEP> is <SEP> a
<tb> Procedure <SEP> for <SEP> I3erstellume <SEP> a <SEP> quaternary
<tb> Ammonium compound <SEP> of a <SEP> bis-aniinoalkoxy alkane. <SEP> The <SEP> procedure is <SEP>. <SEP> dadureh <SEP> marked, <SEP> that <SEP> man <SEP> on <SEP> one <SEP> mol <SEP> 1,70-bis - [/ 3 (metllyl-butwl-amino) - ä.tlroxy] -dekan <SEP> two <SEP> mol
<tb>: Vlethylbronrid <SEP> can act <SEP>.
<tb>



  The <SEP> received <SEP> new <SEP> connection, <SEP> the <SEP> <B><I>1,10-</I> </B>
<tb> 1) i- <SEP> [ss- (dimetliyl <SEP> -butyl <SEP> -ammoniriin <SEP>) -ä.thoxv-i <SEP> decan-dibromide, <SEP> melts <SEP> at <SEP> 1.48 <SEP> to <SEP> 149. <SEP> you
<tb> should be <SEP> therapeutic <SEP> use <SEP>.
<tb>



  <I> Example: </I>
<tb> 20 <SEP> parts <SEP> 1,10-bis- [ss- (methyl-butyl-arnino) eth. oxyl-clekan <SEP> become <SEP> with. <SEP> 80 <SEP> Split <SEP> dry <SEP> Aeetorr <SEP> and <SEP> 1 \? <SEP> share <SEP> methyl bromide <SEP> 74
<tb> hours <SEP> in the <SEP> melting tube <SEP> in <SEP> a <SEP> water bath <SEP> heated from <SEP> 50 <SEP> to <SEP> 60 <SEP>.

   <SEP> After <SEP> has cooled down
<tb> <SEP> is suctioned off <SEP> and <SEP> the <SEP> obtained <SEP> 1,10-di- [ss- (dimethyl - butyl - ammonium) - ethoxy] - decandic dihromide, if desired, by recrystallization sizing from butanone + little abs. Methanol (incorporated by dissolving the salt in as little hot methanol as possible and then as much.

    hot butanone is added so that everything remains dissolved in the heat. The recrystallized product melts at 148 to 149.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- niiren Amnioniumverbindung eines Bis-amino- alkoxy-a.lkans, dadureh gekennzeichnet, dass inan auf ein Mol 1,10-Bis-[ss-(methyl.-butyl- amino)-äthox)-]-dekan zwei Mol Methylbromid einwirken lässt. PATENT CLAIM: Process for the preparation of a quaternary amnionium compound of a bis-amino-alkoxy-a.lkane, characterized in that one mole of 1,10-bis- [ss- (methyl-butyl-amino) ethoxy) - ] -dekan allows two moles of methyl bromide to act. Die erhaltene neue Verbindung, das 1,10- Di- [ss-(dimethyl -ibutyl - ammonium) -äthoxy] - dekan-dibromid, sehmilzt bei 148 bis 149 . The new compound obtained, the 1,10-di- [ss- (dimethyl-i-butyl-ammonium) -ethoxy] -decane dibromide, sehmelzt at 148 to 149.
CH293943D 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH293943A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH293943T 1949-12-07
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH293943A true CH293943A (en) 1953-10-15

Family

ID=25733003

Family Applications (1)

Application Number Title Priority Date Filing Date
CH293943D CH293943A (en) 1949-12-07 1949-12-07 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH293943A (en)

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