CH293568A - Process for the preparation of a nucleotide compound of a factor of the vitamin B complex. - Google Patents

Process for the preparation of a nucleotide compound of a factor of the vitamin B complex.

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Publication number
CH293568A
CH293568A CH293568DA CH293568A CH 293568 A CH293568 A CH 293568A CH 293568D A CH293568D A CH 293568DA CH 293568 A CH293568 A CH 293568A
Authority
CH
Switzerland
Prior art keywords
vitamin
complex
factor
acid
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
L Dr Ruskin Simon
Original Assignee
L Dr Ruskin Simon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L Dr Ruskin Simon filed Critical L Dr Ruskin Simon
Publication of CH293568A publication Critical patent/CH293568A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren     zur    Herstellung einer     Nueleotidverbindung    eines Faktors des     Vitamin-B-Komplexes.       Im Hauptpatent Nr. 290136 ist ein Verfah  ren zur Gewinnung von therapeutisch wert  vollen Verbindungen der     Adenylsäure    mit  Faktoren des     Vitamin@B-Komplexes    beschrie  ben.  



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung einer neuen.  Verbindung der     Adenylsäure    mit einem Fak  tor des     Vitamin-B-Komplexes,    welches dadurch  gekennzeichnet ist, dass 2     Mol        Nikotinsäure-          amid    bzw. eines 'Salzes desselben mit 1     Mol          Adenylsäure    bzw.     eines    Salzes derselben zur  Reaktion gebracht werden. Das so erhaltene       1)i-nieotylamid-adenylat    ist ein farbloses     kri-          stallines    Produkt vom     Schmelzpunkt    103  C.  



  Man kann zum Beispiel ein Salz des     Niko-          t-insäure-amids    mit einem     Metallsalz    der       Adenylsäure    umsetzen, doch wird vorgezogen,  die freie Base mit der freien     .Säure    zur Reak  tion zu bringen,     und;    zwar vorzugsweise im  wässerigen Medium unter Wärmezufuhr. Die  erhaltene wässerige Lösung kann allenfalls  ohne weitere Behandlung per os verabreicht  werden. Für Injektionen wird sie zweckmässig  mit Natronlauge auf einen geeigneten     pH-Wert     eingestellt.  



  Durch Eindampfen der Lösung im Vakuum       kann    ein Trockenpräparat gewonnen werden,  welches in Form von Pulver oder     (''ranulen     verabreicht werden kann.  



  Es wurde gefunden, dass bei einer Dosie  rung-von 5 bis 10 mg     Di-nicotylamid-adenylat       ein- bis dreimal täglich eine sichere Wirkung  erzielt wird.  



  <I>Beispiel:</I>  0,347 (0,001     Mol)        Adenylsäure        wurden    in  10     cms        -\V.asser    suspendiert und     sodann        0,244        ;-          (0,00'2        Mol)        Nikotinsäure-amid    zugesetzt. Beim  Erhitzen zum     Siedepunkt    trat     vollständige    Lö  sung ein.

   Die     Reaktionsmischung    wurde     im          Vakuum    zur Trockene     eingedampft.    Es wurde  in quantitativer Ausbeute     Di-nicotylamid-          aden3rlat    als farbloses, kristallines Produkt  vom     ,Schmelzpunkt    103  C erhalten.  



  Da die     Adenylsäure    zweimal leichter     in     Wasser löslich ist bei Gegenwart von     Nikotin-          säiire-amid    als bei dessen Abwesenheit, muss  angenommen werden, dass eine chemische Ver  bindung der     Reaktionskomponenten,    und zwar  eine Salzbildung, erfolgt.



  Process for the preparation of a nucleus compound of a factor of vitamin B complex. In the main patent no. 290136 a method for obtaining therapeutically valuable compounds of adenylic acid with factors of the vitamin @ B complex is described ben.



  The present patent is a method for producing a new one. Compound of adenic acid with a factor of the vitamin B complex, which is characterized in that 2 moles of nicotinic acid amide or a salt thereof are reacted with 1 mole of adenic acid or a salt thereof. The 1) i-nieotylamide adenylate obtained in this way is a colorless, crystalline product with a melting point of 103 C.



  For example, a salt of nicotinamide can be reacted with a metal salt of adenylic acid, but it is preferred to react the free base with the free acid, and; although preferably in an aqueous medium with the supply of heat. The aqueous solution obtained can at best be administered orally without further treatment. For injections, it is expediently adjusted to a suitable pH value with sodium hydroxide solution.



  By evaporating the solution in a vacuum, a dry preparation can be obtained, which can be administered in the form of powder or ('' ranules.



  It has been found that with a dosage of 5 to 10 mg of di-nicotylamide adenylate one to three times a day a safe effect is achieved.



  <I> Example: </I> 0.347 (0.001 mol) adenylic acid was suspended in 10 cms - \ V. water and then 0.244; - (0.00'2 mol) nicotinic acid amide was added. Complete solution occurred on heating to the boiling point.

   The reaction mixture was evaporated to dryness in vacuo. Di-nicotylamide adene3rlate was obtained in quantitative yield as a colorless, crystalline product with a melting point of 103 ° C.



  Since adenylic acid is twice as soluble in water in the presence of nicotinic acid amide than in its absence, it must be assumed that a chemical connection of the reaction components, namely salt formation, takes place.

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung einer neuen Verbindung der Ad-enylsäure mit einem Fak tor des Vitamin-B-Komplexes, dadurch ge kennzeichnet, dass 2 111o1 Nikotinsäure-amid bzw. eines Salzes desselben mit 1 Mol Adenyl- säure bzw. eines Salzes derselben zur Reaktion gebracht werden. PATENT CLAIM Process for the production of a new compound of ad-enylic acid with a factor of the vitamin B complex, characterized in that 2 111o1 nicotinic acid amide or a salt thereof with 1 mole adenyl acid or a salt thereof for reaction to be brought. Das so erhaltene Di-nicotyl- amid-adenylat ist ein farbloses kristallines Produkt. vom Schmelzpunkt 103 C. UNTERANSPRÜCHE: 1. Verfahren, nach Patentanspruch, da durch gekennzeichnet, dass die Reaktion in wässerigem Medium unter Wärmezufuhr durchgeführt wird. 2. Verfahren nach Patentanspruch und Unteranspruch 1, dadurch gekennzeichnet, dass die Lösung zwecks Gewinnung eines Trockenpräparates im Vakuum eingedampft. wird. The di-nicotyl amide adenylate obtained in this way is a colorless crystalline product. from melting point 103 C. SUBClaims: 1. Method according to claim, characterized in that the reaction is carried out in an aqueous medium with the supply of heat. 2. The method according to claim and dependent claim 1, characterized in that the solution is evaporated in vacuo to obtain a dry preparation. becomes.
CH293568D 1948-02-28 1948-02-28 Process for the preparation of a nucleotide compound of a factor of the vitamin B complex. CH293568A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH293568T 1948-02-28

Publications (1)

Publication Number Publication Date
CH293568A true CH293568A (en) 1953-09-30

Family

ID=4488222

Family Applications (1)

Application Number Title Priority Date Filing Date
CH293568D CH293568A (en) 1948-02-28 1948-02-28 Process for the preparation of a nucleotide compound of a factor of the vitamin B complex.

Country Status (1)

Country Link
CH (1) CH293568A (en)

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