CH282875A - Process for the production of an organic mercury compound. - Google Patents
Process for the production of an organic mercury compound.Info
- Publication number
- CH282875A CH282875A CH282875DA CH282875A CH 282875 A CH282875 A CH 282875A CH 282875D A CH282875D A CH 282875DA CH 282875 A CH282875 A CH 282875A
- Authority
- CH
- Switzerland
- Prior art keywords
- production
- water
- organic mercury
- mercury
- theobromine
- Prior art date
Links
- 229940100892 mercury compound Drugs 0.000 title claims description 5
- 150000002731 mercury compounds Chemical class 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- BTFHIKZOEZREBX-UHFFFAOYSA-N 3,7-dimethyl-1-prop-2-enylpurine-2,6-dione Chemical compound CN1C(=O)N(CC=C)C(=O)C2=C1N=CN2C BTFHIKZOEZREBX-UHFFFAOYSA-N 0.000 claims description 4
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 claims description 4
- 230000001882 diuretic effect Effects 0.000 claims description 4
- 208000004880 Polyuria Diseases 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000000047 product Substances 0.000 description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 229910052753 mercury Inorganic materials 0.000 description 3
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 description 3
- 150000003212 purines Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- GMDGTZURDSVMTN-UHFFFAOYSA-N 3-[2-(diethylamino)propyl]-7-methylpurine-2,6-dione Chemical compound C(C)N(C(C)CN1C(NC(C=2N(C=NC1=2)C)=O)=O)CC GMDGTZURDSVMTN-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
- C07F3/14—Heterocyclic substances containing mercury
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Description
<B>verfahren zur Herstellung einer organischen Quecksilberverbindung.</B> Bekanntlich reagieren die Umsetzungs produkte zwischen zum Beispiel Mercuri- acetat und 1-Allyl-theobromin in wässriger Lösung sauer und sind nicht unbegrenzt halt bar. Besonders diese saure Reaktion gibt bei der parenteralen Anwendung als Diureticum Anlass zu Klagen über schlechte Verträglich keit.
Es wurde nun gefunden, sass man orga nische Quecksilberverbindungen, welche was serlöslich sind und neutral reagieren, erhalten kann, wenn man die durch Reaktion von Quecksilbersalzen und Purinderivaten mit ungesättigter Seitenkette gewonnenen, was serlöslichen, sauren Quecksilberanlagerungs- produkte auf basisch substituierte Purin- derivate einwirken lässt.
Als basisch substituierte Purinderivate kön nen zum Beispiel solche verwendet werden, de ren basische Gruppe direkt oder mittels einer oder mehreren Methylengruppen oder mittels Methylengruppen und andern aliphatischen oder aromatischen oder heterocy clischen Resten an die N-Atome in 1-, 3- oder 7 Stellung gebunden ist.
Gegenstand des Patentes ist nun ein Ver fahren zur Herstellung einer organischen Quecksilberverbindung, welches dadurch ge kennzeichnet ist, sass man das durch Um setzung von Quecksilberacetat mit 1-Allyl- theobromin erhältliche wasserlösliche saure Anlagerungsprodukt auf 1-Diäthylamino- äthyltheobromin einwirken lässt. Die so ge wonnene Komplexverbindung stellt ein farb loses, in Wasser leicht lösliches Pulver dar. Sie ist besonders gut verträglich und zeigt eine verstärkte diuretische Wirkung.
<I>Beispiel:</I> 5 g Quecksilberacetat-AnlagerLtngsverbin- dung von 1-Allyl-theobromin und 1 g 1-Di- äthylaminoäthy 1-theobromin werden in 4.1 emj Wasser zusammengegeben. Dabei tritt Lösung ein. Diese Lösung stellt eine 10 /oige klare, haltbare und neutrale Flüssigkeit dar, die mit guter Verträglichkeit als Therapeutikum direkt Verwendung finden kann.
Wird diese Lösung im Vakuum zur Trockne eingedampft, so erhält man als Rück stand die neutrale, feste Komplexverbindung des sauren Quecksilbera.cetat-AllyItheobromin- Anla.gerungsproduktes. Die so gewonnene Komplexverbindung stellt ein farbloses, in Wasser leicht lösliches Pulver dar, das beson ders gut verträglich ist und eine verstärkte diuretische Wirkung zeigt.
<B> Process for the production of an organic mercury compound. </B> It is well known that the reaction products between, for example, mercury acetate and 1-allyl-theobromine react acidic in aqueous solution and cannot be kept indefinitely. In parenteral use as a diuretic, this acidic reaction in particular gives rise to complaints about poor tolerability.
It has now been found that organic mercury compounds, which are soluble in water and react neutrally, can be obtained if the acidic mercury additive products obtained by reaction of mercury salts and purine derivatives with unsaturated side chains, which are soluble in acidic mercury addition products, act on basic substituted purine derivatives leaves.
Basically substituted purine derivatives which can be used are, for example, those whose basic group is bonded directly or by means of one or more methylene groups or by means of methylene groups and other aliphatic or aromatic or heterocyclic radicals to the N atoms in the 1-, 3- or 7-position is.
The subject of the patent is a process for the production of an organic mercury compound, which is characterized in that the water-soluble acidic addition product obtained by reacting mercury acetate with 1-allyl theobromine is allowed to act on 1-diethylamino-ethyl theobromine. The complex compound obtained in this way is a colorless powder that is easily soluble in water. It is particularly well tolerated and has an increased diuretic effect.
<I> Example: </I> 5 g of mercury acetate additive compound of 1-allyl-theobromine and 1 g of 1-diethylaminoethy-1-theobromine are combined in 4.1 emj of water. Solution occurs. This solution is a 10% clear, stable and neutral liquid that can be used directly as a therapeutic agent with good tolerance.
If this solution is evaporated to dryness in a vacuum, the residue obtained is the neutral, solid complex compound of the acidic mercury acetate-allyl theobromine addition product. The complex compound obtained in this way is a colorless powder that is easily soluble in water, is particularly well tolerated and has an increased diuretic effect.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH282875T | 1949-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH282875A true CH282875A (en) | 1952-05-15 |
Family
ID=4483864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH282875D CH282875A (en) | 1949-12-02 | 1949-12-02 | Process for the production of an organic mercury compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH282875A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE946539C (en) * | 1951-09-26 | 1956-08-02 | Ciba Geigy | Process for the production of new mercury-containing dioxypropane compounds |
-
1949
- 1949-12-02 CH CH282875D patent/CH282875A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE946539C (en) * | 1951-09-26 | 1956-08-02 | Ciba Geigy | Process for the production of new mercury-containing dioxypropane compounds |
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