DEP0013084DA - Process for the production of organic mercury compounds - Google Patents
Process for the production of organic mercury compoundsInfo
- Publication number
- DEP0013084DA DEP0013084DA DEP0013084DA DE P0013084D A DEP0013084D A DE P0013084DA DE P0013084D A DEP0013084D A DE P0013084DA
- Authority
- DE
- Germany
- Prior art keywords
- mercury
- production
- mercury compounds
- organic mercury
- acidic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 150000002731 mercury compounds Chemical class 0.000 title claims description 3
- 229940100892 mercury compounds Drugs 0.000 title claims description 3
- 238000000034 method Methods 0.000 title claims description 3
- 230000002378 acidificating Effects 0.000 claims description 5
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 4
- 229910052753 mercury Inorganic materials 0.000 claims description 4
- 229940083251 peripheral vasodilators Purine derivatives Drugs 0.000 claims description 4
- 150000002730 mercury Chemical class 0.000 claims description 2
- 230000000996 additive Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- 239000000243 solution Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001264 neutralization Effects 0.000 description 3
- 150000003212 purines Chemical class 0.000 description 3
- YAPQBXQYLJRXSA-UHFFFAOYSA-N Theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 2
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 description 2
- 230000001396 anti-anti-diuretic Effects 0.000 description 2
- 230000001882 diuretic Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZGIBYCLLIMGXEZ-UHFFFAOYSA-N 1,3-dimethyl-7-prop-2-enylpurine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC=C)C=N2 ZGIBYCLLIMGXEZ-UHFFFAOYSA-N 0.000 description 1
- BRMYZIKAHFEUFJ-UHFFFAOYSA-L Mercury(II) acetate Chemical compound CC(=O)O[Hg]OC(C)=O BRMYZIKAHFEUFJ-UHFFFAOYSA-L 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 229960004559 Theobromine Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000004429 atoms Chemical group 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 231100000730 tolerability Toxicity 0.000 description 1
Description
Verfahren zur HerstellunR von prgjani3c_h_en_ Quecksilber Process for the manufacture of prgjani3c_h_en_ mercury
Bekanntlich reagieren die Umsetzungsprodukt@ zwischen z.B. Mercuri-acetat und I-Allyltheobromin in wässeriger Lösung sauer und sind nicht unbegrenzt haltbar. Besonders diese saure ReaktionIt is known that the reaction products @ between e.g. mercury acetate and I-allyl theobromine react acidic in aqueous solution and are not durable indefinitely. Especially this acidic reaction
gibt bei der parenteralen Anwendung als Diureticum Anlass zu Klagen über schlechte Verträglichkeit.When used parenterally as a diuretic, gives cause for complaints about poor tolerability.
Es wurde nun gefunden, dass man organische Quecksilber* verbindungen, welche wasserlöslich sind und neutral reagieren, erhal» ten kann, wenn man die durch Reaktion von Quecksilbensalzeη und Purinderivaten mit ungesättigter Seitenkette gewonnenen, waeeerlösliehen, sauren Quecksilberanlagerungsprodukte auf basisch Substitut ierte Purinderlvate einwirken läset.It has now been found that organic mercury compounds, which are water-soluble and react neutrally, are obtained » th, if one obtained by the reaction of mercury salts and purine derivatives with unsaturated side chain, waeeerlöshen, acidic mercury addition products to base-substituted purine derivatives.
Als basisch substituierte Purinderivate können z4B. solche verwendet werden, deren basische Gruppe direkt oder mittels einer oder mehrerer Methylengruppen oder mittels Methylengruppen und all« phatischen, aromatischen, heterocyclischen Resten an die^T-Atome der 1-, 3—·oder 7-Stellung gebunden ist.As a basically substituted purine derivatives may, for example, those 4 are used, the basic group phatic directly or via one or more methyl groups or by means of methyl groups and all "aromatic heterocyclic residues on the ^ T atoms in the 1-, 3- or 7 · -Position is tied.
Die so gewonnenen komplexen Verbindungen sind besondere gut verträglich und zeigen eine verstärkte diuretischs Wirkung. Beispiel Ii The complex compounds obtained in this way are particularly well tolerated and show an increased diuretic effect. Example ii
5 Quecksilberacetat^nlagerungsverbindung von I-Allyltheobromin und 1 gf l~Diäthylaminoäthyltheobromin werden in 44 ecm Wasser zusammengegeben. Dabei tritt Lösung ein. Diese Lösung stellt eine IOfcige klare, haltbare und neutrale Flüssigkeit dar, die mit guter Verträglichkeit als Therapeutikum direkt Verwendung finden kann5 mercuric acetate ^ nlagerungsverbindung of I-Allyltheobromin and 1 gf l ~ Diäthylaminoäthyltheobromin are combined in 44 cc of water. Solution occurs. This solution is a clear, stable and neutral liquid that can be used directly as a therapeutic agent and is well tolerated
Wird diese Lösung im Vacuum zur Trockne eingedampft, so erhält man als Rückstand die neutrale, feste Komplexverbindung des sauren Quecksilberanlagerungskörpers mit dem basischen Alkylpurln.If this solution is evaporated to dryness in a vacuum, the residue obtained is the neutral, solid complex compound des acidic mercury sedimentation body with the basic Alkylpurln.
5 Quecks ilberacetatanlagerungsverbindung von 7-Allyltheophyllin werden mit 1 g\ l-Diäthylarrinoüthy ltheobromin in 44 ecm Wasser zu einer klaren neutralen Lösung aufgelöst. Die Lösung zeigt die oben erwähnten Eigenschaften.5 mercury acetate addition compounds of 7-allyl theophylline are dissolved with 1 g of diethylarrinoutethy l theobromine in 44 ecm of water to form a clear, neutral solution. The solution shows the properties mentioned above.
Claims (1)
Family
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