CH235383A

CH235383A - X-ray contrast media.

Info

Publication number: CH235383A
Authority: CH
Inventors: Gmbh Roehm Haas
Original assignee: Roehm & Haas Gmbh
Priority date: 1942-11-02
Filing date: 1943-05-15
Publication date: 1944-11-30
Also published as: DK66159C

Description

       

  



  Röntgenkontrastmittel.



   Für die r¯ntgenologische Darstellung des Magen-Darmkanals werden meist ungiftige, in   Wasser und verdiinnten Sä. uren unlasliche    Metallverbindungen, in erster Linie Bariumsulfat, verwendet. Reines Bariumsulfat gen gt nicht mehr allen Anforderungen der    heutigen Rontgenteohnik. Durch die im letz- ten Jahrzehnt entwickelte Raliefdarstellung    ist die   Herstellunig besonderer-Kontrastmittel    notwendig geworden. Man verlangt heute von einem Kontrastmittel folgende Eigenschaften : leichte Zubereitung,   angenehmer Ge-      schmack, leiehte Trinkbarkeit,, gutes    Haftvermögen auf der Schleimhaut. In   zuberei-    tetem Zustand soll die Kontrastspeise lÏngere Zeit   ohneBodensatzbildunghalten.   



   Um eine möglichst lange haltbare Suspension zu erzielen,   miss'en      jedoch dem Barium-    sulfat reichliche Mengen   Sohutzkolloid zu-    gemischt werden. Als Schutzkolloide zur   Herstellung der Eontrastspeisen können)    beispielsweise Verwendung finden : Agar-Agar,   Leinsamensch'Ieim, Salepschleim, Tragant,    Gummi-arabicum, Methylcellulose,   Johannis-    brotkernmehl, Dextrin, Rohrzucker, Traubenzucker, Maltose,   synthetische wasser-    lösliche Hochpolymere, z. B. polyacrylsaures Natrium und andere mehr.

   Die Schutzkolloide enthaltenden Kontrastmittel bilden aber beim Anrühren starken, zum Teil grob  blasigen    Schaum von hoher Beständigkeit, der Anlass zu   Fehldiagnosen    geben kann.



  Die Technik kennt seit lÏngerer Zeit Schaumdämpfungsmittel in genügender Menge. Diese können jedoch f r die Entschäumung von R¯ntgenkontrastspeisen keine Verwendung finden, da sie für den innern Gebrauch nicht geeignet sind.



   Gegenstand der Erfindung ist ein   unlös-    liche Metallverbindungen, wie Bariumsulfat, ferner   Sohutzkolloide aufweisendes Rontgen-    kontrastmittel,   d'as    mindestens einen   Fett-    säureester eines hoheren Alkohols, wie PalmitinsÏurecetylester, StearinsÏurelaurinester, Palmitinsäuremelissylester und andere, als Schaumdämpfungsmittel enthält. Zweck



  



  X-ray contrast media.



   For the X-ray imaging of the gastrointestinal tract, mostly non-toxic seeds in water and diluted seeds are used. ure insoluble metal compounds, primarily barium sulfate, are used. Pure barium sulfate no longer meets all the requirements of today's Rontgenteohnik. Due to the Ralief display developed in the last decade, the manufacture of special contrast media has become necessary. Today the following properties are required of a contrast medium: easy preparation, pleasant taste, easy drinkability, good adhesion to the mucous membrane. In the prepared state, the contrast food should hold for a longer time without any sedimentation.



   In order to achieve a suspension that is as long as possible, however, copious amounts of protective colloid should be added to the barium sulfate. As protective colloids for the production of contrast dishes, for example, use can be made of: agar-agar, flax seed, salep mucus, tragacanth, gum arabic, methyl cellulose, locust bean gum, dextrin, cane sugar, dextrose, maltose, synthetic water-soluble high polymers, e.g. B. Sodium polyacrylate and others.

   The contrast media containing protective colloids, however, form strong, sometimes coarsely vesified foam of high resistance when mixed, which can give rise to incorrect diagnoses.



  Technology has known foam suppressants in sufficient quantities for a long time. However, these cannot be used for defoaming X-ray contrast dishes, as they are not suitable for internal use.



   The invention relates to an insoluble metal compound, such as barium sulfate, and X-ray contrast agent containing soot colloids, which contains at least one fatty acid ester of a higher alcohol, such as palmitic acid ester, stearic acid lauric ester, palmitic acid melissyl ester and others, as foam suppressants. purpose

Claims

PATENT CLAIM: X-ray contrast medium having insoluble metal compounds and protective colloids, characterized in that it contains at least one fatty acid ester of a higher alcohol as a foam suppressant.

SUBClaims: 1. X-ray contrast medium according to Patentan sprueh characterized by a content of cetyl palmitate.

2. X-ray contrast medium according to patent claim, characterized by a content of stearic acid laurin.

3. X-ray contrast medium according to claim, characterized by a content of PalmitinsÏuremelissylester.

4. X-ray contrast media according to patent application. characterized in that it contains at least one fatty acid ester of a higher alcohol Paraffinum liquidum. only a small amount of the ester is added to a moderate extent, if necessary together with paraf finum liquidum.

According to the invention? Compound X-ray contrast media are non-toxic because of their lack of taste. ity, odorlessness, stability during storage are very special advantages; Since the foam suppressants also have a greasy character, they also act as lubricants.

Examples: 1. 100 g of finely powdered barium sulfate are melissyled with a mixture of 4 g of cane sugar, 4 g of dextrin and 0.75 g of palmitic acid. most carefully mixed. The mixture is passed through a sieve and is ready to use immediately.

2. 100 g of finely powdered barium sulfate are mixed with a. Carefully mixed us 5 g gelatine, 0.25 g palmitic acid cetyl ester and 0.5 g liquid paraffinum.

After grinding, the contrast medium is ready for use.