CH217152A - Process for the preparation of a B-alkyl-substituted ethylamine derivative. - Google Patents
Process for the preparation of a B-alkyl-substituted ethylamine derivative.Info
- Publication number
- CH217152A CH217152A CH217152DA CH217152A CH 217152 A CH217152 A CH 217152A CH 217152D A CH217152D A CH 217152DA CH 217152 A CH217152 A CH 217152A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- dependent
- nickel
- alkyl
- catalyst
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung eines P-alkyl-substituierten äthylamin-Derivates. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Darstellung von ss-Propyl- di-n-butyläthylamin, das dadurch gekenn zeichnet ist, dass man Di-n-butyl-propyl- acetonitril mit Wasserstoff behandelt. Die neue Verbindung soll als Arzneimittel Ver wendung finden.
Für ihre technische Herstellung hat sich am vorteilhaftesten erwiesen das genannte Nitril in Gegenwart von zweckmässig auf Trägern niedergeschlagenen vor allem von auf Kieselgur niedergeschlagenen Nickelkatalysatoren, mit Wasserstoff unter Druck bei erhöhter Tem peratur, z. B. bei 120-140 , zu reduzieren.
Verwendet man sogenannte Raney-gatalysa- toren, die erhalten werden können durch Herauslösen des Aluminiums aus einer Nickel-Aluminium-Legierung, z. B. nach dem Verfahren des amerikanischen Patentes Nr. 1915473, so lässt sich die Reduktion auch bei niederen Temperaturen, z. B. schon bei 7 0 , durchführen.
Beispiel: 80 Teile Di-n-butyl-propylacetonitril K. P.1$ 130-134' wurden mit 6 Teilen Nickelkatalysator versetzt und im Auto klaven unter Wasserstoffdruck bei 120 bis <B>130'</B> reduziert. Naeh Aufnahme der theore tischen Wasserstoffmenge (2-3 Stunden) wird der Katalysator durch Filtration ab getrennt und der Rückstand sublimiert. Man erhält eine Ausbeute von ca. 95 % (d.
Theo rie) an Propyldibutyläthylamin vom K. P.lo 113-114'. <B>D2</B> 5 = 0,8169. n v = 1,4479. Sein Chlorhydrat hat den F. P. 150-151 .
Die Reduktion des Nitrils ist mit gleicher Ausbeute auch durchführbar, wenn man es in einem Schüttelgefäss (oder Rührautokla- ven) unter Zusatz von 3 Teilen Raney-Nickel- katalysator bei<B>60-70'</B> unter einem Druck von 30 cm Wassersäule mit reinem Wasser stoff behandelt, solange noch Wasserstoff aufgenommen wird. Das Reaktionsprodukt wird .dann vom Katalysator getrennt und wie oben gereinigt.
Process for the preparation of a P-alkyl-substituted ethylamine derivative. The present patent relates to a process for the preparation of ss-propyl-di-n-butylethylamine, which is characterized in that di-n-butyl-propyl-acetonitrile is treated with hydrogen. The new compound is to be used as a drug.
For their industrial production, said nitrile has proven to be most advantageous in the presence of suitably precipitated on supports, especially nickel catalysts precipitated on kieselguhr, with hydrogen under pressure at elevated tem perature, eg. B. at 120-140 to reduce.
If you use so-called Raney catalysts, which can be obtained by dissolving the aluminum from a nickel-aluminum alloy, z. B. according to the method of American patent no. 1915473, the reduction can also be carried out at low temperatures, e.g. B. already at 7 0, perform.
Example: 80 parts of di-n-butyl-propylacetonitrile K.P.1 $ 130-134 'were mixed with 6 parts of nickel catalyst and reduced in the car under hydrogen pressure at 120 to 130'. After the theoretical amount of hydrogen has been absorbed (2-3 hours), the catalyst is separated off by filtration and the residue is sublimed. A yield of approx. 95% is obtained (i.e.
Theory) of propyldibutylethylamine from K. P. lo 113-114 '. <B> D2 </B> 5 = 0.8169. n v = 1.4479. Its hydrochloride has the F.P. 150-151.
The reduction of the nitrile can also be carried out with the same yield if it is placed in a shaking vessel (or stirred autoclave) with the addition of 3 parts of Raney nickel catalyst at <B> 60-70 '</B> under a pressure of 30 cm of water column treated with pure hydrogen as long as hydrogen is still being absorbed. The reaction product is then separated from the catalyst and purified as above.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE217152X | 1937-02-26 | ||
CH208253T | 1938-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH217152A true CH217152A (en) | 1941-09-30 |
Family
ID=25724503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH217152D CH217152A (en) | 1937-02-26 | 1938-02-22 | Process for the preparation of a B-alkyl-substituted ethylamine derivative. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH217152A (en) |
-
1938
- 1938-02-22 CH CH217152D patent/CH217152A/en unknown
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