CH213388A - Process for producing a thiazolium compound. - Google Patents

Process for producing a thiazolium compound.

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Publication number
CH213388A
CH213388A CH213388DA CH213388A CH 213388 A CH213388 A CH 213388A CH 213388D A CH213388D A CH 213388DA CH 213388 A CH213388 A CH 213388A
Authority
CH
Switzerland
Prior art keywords
methyl
thiazolium
producing
ethyl
aminopyrimidyl
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH213388A publication Critical patent/CH213388A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Description

  

  Verfahren zur Herstellung einer     Thiazoliumverbindung.       Gegenstand des Patentes ist ein Verfahren  zur     Herstellung    einer     Thiazoliumverbindung,          dadurch        gekennzeichnet,        dass        man     4 -     aminopyrimidyl    - (5) -     methyl)        @-        thio-          formamid        und        y-Chlor-y-acetopropylalkohol     zum     N-(2'-Äthyl-4'-aminopyrimidyl-(5')-me-          thyl)

  -4-methyl-5-oxyäthyl-thiazoliumchlorid          umsetzt.    Das letztere     kann    man zweckmässig  in     Form    seines Hydrochlorids aus der Reak  tionsmischung gewinnen. Dieses lässt sich aus  verdünntem Alkohol     umkristallisieren        und     schmilzt bei 243'. Das neue Verfahrenspro  dukt soll therapeutische     Anwendung    finden.

    <I>Beispiel:</I>  19,6g     N-(2-Äthyl-4-aminopyrimidyl-(5)-          methyl)-thioformamid    und 13,7 g     y-Chlor-y-          acetopropylalkohol    werden in 50 g     konz.          Ameisensäure    gelöst     und    24     Stunden    auf       etwa   <B>50'</B>     unter    Rühren erwärmt.

   Das ent  standene N-(2'-Äthyl-4'-aminopyrimidyl-(5')       methyl)-4-methyl-5-oxyäthyl-thiazoliumchlo-          rid    ist in Wasser löslich; es     wird    zweckmässig  als     Hydrochlorid    isoliert. Dazu     wird    die Re  aktionsmischung in<B>150</B> cm' 10%ige Salz-    säure gegossen, die trübe Lösung mit Tier  kohle geklärt und     unter    vermindertem Druck       zur    Trockne eingeengt. Der Sirupöse Rück  stand kristallisiert beim     Aufkochen    mit Al  kohol. Die Kristalle werden abgesaugt     und     aus verdünntem Alkohol umkristallisiert.

    Man erhält so das Hydrochlorid des     N-(2'-          ÄtUy1-    4'-     aminopyrimidyl    - (5') -     methyl)    - 4  methyl-5-oxyäthyl-thiazoliumchlorids vom       Schmelzpunkt    243  .



  Process for producing a thiazolium compound. The subject of the patent is a process for the preparation of a thiazolium compound, characterized in that 4 - aminopyrimidyl - (5) - methyl) @ - thio-formamide and y-chloro-y-acetopropyl alcohol to N- (2'-ethyl-4 ' -aminopyrimidyl- (5 ') - methyl)

  -4-methyl-5-oxyethyl-thiazolium chloride implemented. The latter can be conveniently obtained in the form of its hydrochloride from the reac tion mixture. This can be recrystallized from dilute alcohol and melts at 243 '. The new procedural product is intended to be used in therapy.

    <I> Example: </I> 19.6 g of N- (2-ethyl-4-aminopyrimidyl- (5) - methyl) -thioformamide and 13.7 g of y-chloro-y-acetopropyl alcohol are concentrated in 50 g. Dissolved formic acid and heated to about <B> 50 '</B> for 24 hours while stirring.

   The resulting N- (2'-ethyl-4'-aminopyrimidyl- (5 ') methyl) -4-methyl-5-oxyethyl-thiazolium chloride is soluble in water; it is conveniently isolated as the hydrochloride. For this, the reaction mixture is poured into 150 cm '10% hydrochloric acid, the cloudy solution is clarified with animal charcoal and concentrated to dryness under reduced pressure. The syrupy residue crystallized when boiled with alcohol. The crystals are filtered off with suction and recrystallized from dilute alcohol.

    The hydrochloride of N- (2'-ÄtUy1-4'-aminopyrimidyl- (5 ') -methyl) -4 methyl-5-oxyethylthiazolium chloride with a melting point of 243 is obtained in this way.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Thiazo- liumverbindung, dadurch gekennzeichnet, dass man N-(2-Äthyl-4-aminopyrimidyl-(5)- methyl)-thioformamid und y-Chlor-y-aceto- propylalkohol zum N - (2'- Äthyl - 4'- amino pyrimidyl-(5')-methyl)-4-methyl-5-oxyäthyl- thiazoliumchlorid umsetzt. Das so erhältliche wasserlösliche, PATENT CLAIM: Process for the production of a thiazolium compound, characterized in that N- (2-ethyl-4-aminopyrimidyl- (5) -methyl) -thioformamide and y-chloro-y-aceto-propyl alcohol are converted to N - (2 ' - Ethyl - 4'-amino pyrimidyl (5 ') - methyl) -4-methyl-5-oxyäthyl thiazolium chloride implemented. The water-soluble, neue Produkt bildet ein bei 243' schmelzendes Hydrochlorid, das in Wasser leicht löslich ist. A new product forms a hydrochloride which melts at 243 'and is easily soluble in water.
CH213388D 1936-01-28 1937-01-08 Process for producing a thiazolium compound. CH213388A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE213388X 1936-01-28
CH206040T 1937-01-08

Publications (1)

Publication Number Publication Date
CH213388A true CH213388A (en) 1941-01-31

Family

ID=25724270

Family Applications (1)

Application Number Title Priority Date Filing Date
CH213388D CH213388A (en) 1936-01-28 1937-01-08 Process for producing a thiazolium compound.

Country Status (1)

Country Link
CH (1) CH213388A (en)

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