CH176256A - Process for the preparation of a new cardiac active glucoside. - Google Patents

Process for the preparation of a new cardiac active glucoside.

Info

Publication number
CH176256A
CH176256A CH176256DA CH176256A CH 176256 A CH176256 A CH 176256A CH 176256D A CH176256D A CH 176256DA CH 176256 A CH176256 A CH 176256A
Authority
CH
Switzerland
Prior art keywords
preparation
new cardiac
glucoside
cardiac active
active glucoside
Prior art date
Application number
Other languages
German (de)
Inventor
Sandoz Chemische Fabri Vormals
Original Assignee
Chem Fab Vormals Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Fab Vormals Sandoz filed Critical Chem Fab Vormals Sandoz
Publication of CH176256A publication Critical patent/CH176256A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines neuen herzwirksamen     Glucosides.       Das vorliegende Verfahren betrifft die  Darstellung von     Digitoxin    und ist dadurch  gekennzeichnet, dass man das     Azetyldigi-          toxin,    welches zum Beispiel nach dem Ver  fahren des Patentes Nr. 171237 hergestellt  werden kann, mit Natronlauge behandelt.  



  <I>Beispiel:</I>  0,2     gr        Azetyldigitoxin,    welches zum Bei  spiel nach dem Verfahren der Patentschrift  Nr. 171237 hergestellt werden kann, werden  in zirka 6     ein'    Methanol gelöst. Zu dieser       Lösung    lässt man 10     em7        einer        %    n. Natron  lauge fliessen, schwenkt um und kratzt mit  dem Glasstab. Alsbald beginnt das     acylfreie     Produkt     auszukristallisieren.    Nach zwei bis    drei Minuten     wird    mit 2o     cm3    Wasser ver  dünnt und nach weiteren zwei Minuten rasch  filtriert.

   Der Rückstand wird mit Wasser  neutral gewaschen und aus     verdünntem    Al  kohol umkristallisiert. Das so gewonnene  Präparat ist mit     Digitoxin    identisch und soll  in der Therapie verwendet werden.



  Process for the preparation of a new cardiac active glucoside. The present method relates to the preparation of digitoxin and is characterized in that the acetyldigitoxin, which can be produced, for example, according to the method of patent no. 171237, is treated with sodium hydroxide solution.



  <I> Example: </I> 0.2 gr acetyldigitoxin, which can be produced for example by the process of patent specification no. 171237, are dissolved in about 6% methanol. 10 em7 of a% sodium hydroxide solution is allowed to flow into this solution, swirled around and scratched with the glass rod. The acyl-free product soon begins to crystallize out. After two to three minutes, dilute with 20 cm3 of water and then filter quickly after another two minutes.

   The residue is washed neutral with water and recrystallized from dilute alcohol. The preparation obtained in this way is identical to Digitoxin and should be used in therapy.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Digitoxin, dadurch gekennzeichnet, dass man Azetyl- digitoxin mit Natronlauge behandelt. Das Glucosid ist mit Digitoxin identisch. Es soll in der Therapie Verwendung finden. PATENT CLAIM: Process for the preparation of digitoxin, characterized in that acetyl digitoxin is treated with sodium hydroxide solution. The glucoside is identical to digitoxin. It should be used in therapy.
CH176256D 1932-07-22 1932-07-22 Process for the preparation of a new cardiac active glucoside. CH176256A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH171174T 1932-07-22
CH176256T 1932-07-22

Publications (1)

Publication Number Publication Date
CH176256A true CH176256A (en) 1935-03-31

Family

ID=25719026

Family Applications (1)

Application Number Title Priority Date Filing Date
CH176256D CH176256A (en) 1932-07-22 1932-07-22 Process for the preparation of a new cardiac active glucoside.

Country Status (1)

Country Link
CH (1) CH176256A (en)

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