CH148291A - Disinfection method. - Google Patents

Disinfection method.

Info

Publication number
CH148291A
CH148291A CH148291DA CH148291A CH 148291 A CH148291 A CH 148291A CH 148291D A CH148291D A CH 148291DA CH 148291 A CH148291 A CH 148291A
Authority
CH
Switzerland
Prior art keywords
sep
sterile
ether
growth
hydroquinone
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH148291A publication Critical patent/CH148291A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  



  Verfahren zur Desinfektion.



   Gegenstand der vorliegenden   Erssndung    ist ein Verfahren zur Desinfektion, welches durch die Verwendung von eine   Hydroxyl-    gruppe enthaltenden Derivaten des   Diphenyl-    oxyds gekennzeichnet
Es wurde gefunden, dass der Hydrochinon  phenyläther,    welchem die Formel
EMI1.1     
 zukommt, gegenüber dem Phenol eine wesent  lich    gesteigerte baktericide Wirkung entfaltet.



  Der   Hydrochinonphenyl-p-oxyphenyläther,   
EMI1.2     
 eine Substanz vom Schmelzpunkt   100 ,    die auf verschiedene Art, zum Beispie] durch Schmelzen des Kalisalzes des   Hydrochinon-      phenylathers    mit   p-Bromanisol    unter   jupier-    zusatz und Verseifen des erhaltenen Hydro  chinonphenyl-methoxy-phenyläthers,    erhalten werden kann, zeigt ebenfalls gute baktericide
Wirkung. Auch Produkte mit einer noch    gröBeren    Anzahl von Benzolkernen wirken stark desinfizierend. Gebilde, welche mehrere
Benzolkerne nur durch   Sauerstoffbrüoken    mit einander verbunden enthalten, sollen mit dem umfassenden Namen   Polyphenylpolyoxyde    be zeichnet werden.

   Die beanspruchten Substan zen haben ausser ihrer bedeutenden Desinfek tionskraft den grossen Vorteil, dass sie weniger giftig sind, als die gewöhnlichen Phenole,
Kresole etc. Infolgedessen ist ihre   Anwen-       dung    mit geringeren Gefahren für Mensch und Tier verbunden. Ein weiterer Vorzug besteht in ihrer   Geruch-und      Reizlosigkeit.   



   Ausser den Phenolen selbst können auch deren Derivate, zum   Beispiel. Halogensubsti-    tutionsprodukte, Sulfosäuren, Quecksilberderivate etc., mit Vorteil verwendet werden.



   Die Wirksamkeit des   Hydrochinonmono-      phenyläthers, des Hydrochinon-p-tolylathers   
EMI1.3     
 des   o-Chlorhydrochinonpbenyläthers   
EMI2.1     
 im Vergleich zur Wirksamkeit von Phenol und   Sublimat    zeigt nachstehende Zusammenstellung. Es   bedeutet ; 0=steril, +=Wachs-    tum.

   Die Versuche wurden in Bouillon durchgeführt :
EMI2.2     


<tb>  <SEP>    keimhemmende <SEP> Wirkung <SEP> sterilisierende    <SEP> Wirkung
<tb>  <SEP> Präparat
<tb>  <SEP>    Coti    <SEP>    I <SEP> Staphylo <SEP> Coli <SEP> Staphylo    <SEP> 
<tb>  <SEP> 1/500 <SEP> nach <SEP>    1/5000    <SEP> nach
<tb>  <SEP>    Hydroohinon-1/5000=0 <SEP> 1/5000=0 <SEP> 10'Wachstum <SEP> 15'Wachstum    <SEP> 
<tb>  <SEP> monophenyläther <SEP> 1/7500 <SEP> = <SEP> + <SEP> | <SEP> 1/7500 <SEP> = <SEP> + <SEP> | <SEP> nach <SEP> | <SEP> nach
<tb>  <SEP> 15'steril <SEP> 30'steril
<tb>  <SEP> 1/5000 <SEP> nach <SEP> 1/5000 <SEP> nach
<tb>  <SEP> Hydrochinon-p-| <SEP> 10' <SEP> steril| <SEP> 10' <SEP> steril
<tb> 1/10000 <SEP> = <SEP> 0 <SEP> | <SEP> 1/20000 <SEP> = <SEP> 0
<tb>  <SEP> 

  tolyläther <SEP> | <SEP> 1/10000 <SEP> nach <SEP> | <SEP> 1/10000 <SEP> nach|
<tb>  <SEP> 30'steril <SEP>    60'steril    <SEP> 
<tb>  <SEP> o-Chlorhydro- <SEP> | <SEP> 1/10000 <SEP> nach <SEP> | <SEP> 1/10000 <SEP> nach
<tb>  <SEP> 1/20000 <SEP> = <SEP> 0 <SEP> | <SEP> 1/20000 <SEP> = <SEP> 0
<tb>  <SEP> chinonphenyl- <SEP> | <SEP> 30' <SEP> steril <SEP> | <SEP> 30' <SEP> steril
<tb>  <SEP>    ather    <SEP> 
<tb>  <SEP>    1/100    <SEP> nach <SEP> 1/100 <SEP> nach
<tb>  <SEP> 1/250 <SEP> = <SEP> 0 <SEP> | <SEP> 1/250 <SEP> = <SEP> 0 <SEP> | <SEP> 5' <SEP> steril <SEP> | <SEP> 10' <SEP> Wachstum
<tb> Phenol
<tb>  <SEP> 1/500 <SEP> = <SEP> + <SEP> | <SEP> 1/500 <SEP> = <SEP> + <SEP> | <SEP> 1/200 <SEP> nach <SEP> | <SEP> nach
<tb>  <SEP> 90' <SEP> Wachstum <SEP> |15' <SEP> steril
<tb>  <SEP> 1/1000 <SEP> nach
<tb>  

  <SEP> 1/2000 <SEP> = <SEP> 0 <SEP> | <SEP> 1/3000 <SEP> = <SEP> 0 <SEP> | <SEP> 10' <SEP> Wachstum <SEP> | <SEP> 1/1000 <SEP> nach
<tb> Sublimat
<tb>  <SEP> 1/3000 <SEP> = <SEP> + <SEP> | <SEP> 1/4000 <SEP> = <SEP> + <SEP> | <SEP> nach <SEP> | <SEP> 90' <SEP> Wachstum
<tb>  <SEP> 15'steril
<tb> 
Eine fast ebenso stark   eimhemmende    Wirkung, wie der Hydrochinonmonophenyl äther zeigt auch der   p.      p'-Dioxyphenyläther   
EMI2.3     
 sowie der Benzeatechinmonophenyläther
EMI2.4     

Das beanspruchte Verfahren soll zur   Keim-      freimachung    von Sputum, Fäces und andern bakterienhaltigen Produkten dienen.



  



  Disinfection method.



   The subject matter of the present invention is a method for disinfection, which is characterized by the use of derivatives of diphenyl oxide containing a hydroxyl group
It has been found that the hydroquinone is phenyl ether, which has the formula
EMI1.1
 comes to, compared to the phenol developed a wesent Lich increased bactericidal effect.



  The hydroquinone phenyl p-oxyphenyl ether,
EMI1.2
 a substance with a melting point of 100, which can be obtained in various ways, for example by melting the potassium salt of hydroquinone phenyl ether with p-bromanisole with the addition of jupier and saponifying the resulting hydroquinonophenyl methoxyphenyl ether, also shows good bactericides
Effect. Even products with an even larger number of benzene nuclei have a strong disinfectant effect. Structures which several
Benzene nuclei only contain oxygen bonds connected to one another, should be characterized by the comprehensive name polyphenyl polyoxides.

   In addition to their significant disinfectant power, the claimed substances have the great advantage that they are less toxic than the common phenols,
Cresols etc. As a result, their use is associated with less danger to humans and animals. Another advantage is their lack of odor and irritation.



   In addition to the phenols themselves, their derivatives, for example. Halogen substitution products, sulfonic acids, mercury derivatives, etc., can be used with advantage.



   The effectiveness of hydroquinone monophenyl ether, hydroquinone p-tolyl ether
EMI1.3
 of o-chlorohydroquinone benzyl ether
EMI2.1
 in comparison to the effectiveness of phenol and sublimate is shown below. It means ; 0 = sterile, + = growth.

   The experiments were carried out in bouillon:
EMI2.2


<tb> <SEP> germ-inhibiting <SEP> effect <SEP> sterilizing <SEP> effect
<tb> <SEP> preparation
<tb> <SEP> Coti <SEP> I <SEP> Staphylo <SEP> Coli <SEP> Staphylo <SEP>
<tb> <SEP> 1/500 <SEP> after <SEP> 1/5000 <SEP> after
<tb> <SEP> Hydroohinon-1/5000 = 0 <SEP> 1/5000 = 0 <SEP> 10 'growth <SEP> 15' growth <SEP>
<tb> <SEP> monophenyl ether <SEP> 1/7500 <SEP> = <SEP> + <SEP> | <SEP> 1/7500 <SEP> = <SEP> + <SEP> | <SEP> after <SEP> | <SEP> after
<tb> <SEP> 15 'sterile <SEP> 30' sterile
<tb> <SEP> 1/5000 <SEP> after <SEP> 1/5000 <SEP> after
<tb> <SEP> hydroquinone-p- | <SEP> 10 '<SEP> sterile | <SEP> 10 '<SEP> sterile
<tb> 1/10000 <SEP> = <SEP> 0 <SEP> | <SEP> 1/20000 <SEP> = <SEP> 0
<tb> <SEP>

  tolyl ether <SEP> | <SEP> 1/10000 <SEP> after <SEP> | <SEP> 1/10000 <SEP> after |
<tb> <SEP> 30 'sterile <SEP> 60' sterile <SEP>
<tb> <SEP> o-Chlorhydro- <SEP> | <SEP> 1/10000 <SEP> after <SEP> | <SEP> 1/10000 <SEP> after
<tb> <SEP> 1/20000 <SEP> = <SEP> 0 <SEP> | <SEP> 1/20000 <SEP> = <SEP> 0
<tb> <SEP> quinonophenyl- <SEP> | <SEP> 30 '<SEP> sterile <SEP> | <SEP> 30 '<SEP> sterile
<tb> <SEP> ather <SEP>
<tb> <SEP> 1/100 <SEP> after <SEP> 1/100 <SEP> after
<tb> <SEP> 1/250 <SEP> = <SEP> 0 <SEP> | <SEP> 1/250 <SEP> = <SEP> 0 <SEP> | <SEP> 5 '<SEP> sterile <SEP> | <SEP> 10 '<SEP> growth
<tb> phenol
<tb> <SEP> 1/500 <SEP> = <SEP> + <SEP> | <SEP> 1/500 <SEP> = <SEP> + <SEP> | <SEP> 1/200 <SEP> after <SEP> | <SEP> after
<tb> <SEP> 90 '<SEP> growth <SEP> | 15' <SEP> sterile
<tb> <SEP> 1/1000 <SEP> after
<tb>

  <SEP> 1/2000 <SEP> = <SEP> 0 <SEP> | <SEP> 1/3000 <SEP> = <SEP> 0 <SEP> | <SEP> 10 '<SEP> growth <SEP> | <SEP> 1/1000 <SEP> after
<tb> sublimate
<tb> <SEP> 1/3000 <SEP> = <SEP> + <SEP> | <SEP> 1/4000 <SEP> = <SEP> + <SEP> | <SEP> after <SEP> | <SEP> 90 '<SEP> growth
<tb> <SEP> 15 'sterile
<tb>
An almost as strong eim-inhibiting effect as the hydroquinone monophenyl ether also shows the p. p'-dioxyphenyl ether
EMI2.3
 as well as benzeatine monophenyl ether
EMI2.4

The claimed method is intended to remove germs from sputum, faeces and other products containing bacteria.

Claims (1)

PATENTANSPRUCH : Verfahren zur Desinfektion, gekennzeich- net durch die Verwendung von eine Hydroxylgruppe enthaltenden Derivaten des Diphenyl oxyds. PATENT CLAIM: Process for disinfection, characterized by the use of derivatives of diphenyl oxide containing a hydroxyl group.
CH148291D 1930-03-29 1930-03-29 Disinfection method. CH148291A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH148291T 1930-03-29

Publications (1)

Publication Number Publication Date
CH148291A true CH148291A (en) 1931-07-15

Family

ID=4404145

Family Applications (1)

Application Number Title Priority Date Filing Date
CH148291D CH148291A (en) 1930-03-29 1930-03-29 Disinfection method.

Country Status (1)

Country Link
CH (1) CH148291A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1053989A2 (en) * 1999-05-20 2000-11-22 Ciba SC Holding AG Hydroxydiphenyl ether compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1053989A2 (en) * 1999-05-20 2000-11-22 Ciba SC Holding AG Hydroxydiphenyl ether compounds
EP1053989A3 (en) * 1999-05-20 2004-01-21 Ciba SC Holding AG Hydroxydiphenyl ether compounds
US7105577B2 (en) 1999-05-20 2006-09-12 Ciba Specialty Chemicals Corporation Antimicrobial method using a hydroxydiphenyl ether compound
KR100729543B1 (en) * 1999-05-20 2007-06-19 시바 스페셜티 케미칼스 홀딩 인크. Hydroxydiphenyl ether compounds

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