CH146546A - Process for the preparation of a basic ether of the pyridine series. - Google Patents

Process for the preparation of a basic ether of the pyridine series.

Info

Publication number
CH146546A
CH146546A CH146546DA CH146546A CH 146546 A CH146546 A CH 146546A CH 146546D A CH146546D A CH 146546DA CH 146546 A CH146546 A CH 146546A
Authority
CH
Switzerland
Prior art keywords
preparation
basic ether
pyridine series
ether
basic
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH146546A publication Critical patent/CH146546A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines basischen Äthers der     Pyridinreihea       Es wurde gefunden, dass man zu einem  basischen Äther der     Pyridinreihe    gelangen  kann, wenn man     Diäthylaminoäthanol    auf       2-Halogenpyridin    in Gegenwart säurebinden  der Mittel einwirken lässt.  



  Das entstandene     2-Diäthylaminoäthoxy-          pyridin    bildet ein farbloses Öl vom     Sdp.     98-100  bei 2 mm Druck. Es ist in Wasser  schwer, in organischen Lösungsmitteln und in  Säuren leicht löslich. Das farblose     1Vlonochlor-          hydrat    der Base schmilzt bei     13511.     



  Die neue Base soll als solche oder als  Zwischenprodukt für therapeutische Zwecke  Verwendung finden.  



  <I>Beispiel:</I>  Eine Lösung von 2,8 Teilen Natrium in  80 Teilen     Diäthylaminoäthanol    wird mit 11,3  Teilen     2-Chlorpyridin    versetzt und im Ölbad  erwärmt. Nach beendigter Reaktion wird der  überschüssige     Aminoalkohol        abdestilliert    und  die neue Base durch Aufnahme in Äther  und     Vertreibung    des Lösungsmittels isoliert.    Durch Destillation erhält     inan    die Base in  reiner Form.  



  An Stelle von     2-Chlorpyridin        können     auch andere     2-Halogenpyridine        Verwendung     finden.



  Process for the preparation of a basic ether of the pyridine series It has been found that a basic ether of the pyridine series can be obtained if diethylaminoethanol is allowed to act on 2-halopyridine in the presence of acid-binding agents.



  The resulting 2-diethylaminoethoxypyridine forms a colorless oil with a boiling point of 98-100 at 2 mm pressure. It is difficult in water, easily soluble in organic solvents and acids. The colorless 1Vlonochlorohydrate of the base melts at 13511.



  The new base is intended to be used as such or as an intermediate for therapeutic purposes.



  <I> Example: </I> A solution of 2.8 parts of sodium in 80 parts of diethylaminoethanol is mixed with 11.3 parts of 2-chloropyridine and heated in an oil bath. After the reaction has ended, the excess amino alcohol is distilled off and the new base is isolated by being taken up in ether and expelled from the solvent. The base is obtained in pure form by distillation.



  Instead of 2-chloropyridine, other 2-halopyridines can also be used.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines basischen Äthers der Pyridonreihe, dadurch gekenn zeichnet, dass man Diäthylaininoätliariol auf 2-Halogenpyridin in Gegenwart säurebinden der Mittel einwirken lässt. Das entstandene 2-Diäthylamirroäthoxy-py- ridin bildet ein farbloses Öl von Sdp. 98-100 bei 2 mm Druck. Es ist in Wasser schwer, in organischen Lösungsmitteln und in Säuren leicht löslich. PATENT CLAIM: Process for the preparation of a basic ether of the pyridone series, characterized in that diethylaininoätliariol is allowed to act on 2-halopyridine in the presence of acid-binding agents. The 2-diethylamirroethoxy-pyridine formed forms a colorless oil with a boiling point of 98-100 at 2 mm pressure. It is difficult in water, easily soluble in organic solvents and acids. Das farblose NIonochlorhydrat der Base schmilzt bei<B>135'.</B> Die neue Base soll als solche oder als Zwischenprodukt für therapeutische Zwecke Verwendung finden. The colorless non-chlorohydrate of the base melts at <B> 135 '. </B> The new base is intended to be used as such or as an intermediate for therapeutic purposes.
CH146546D 1929-08-10 1929-08-10 Process for the preparation of a basic ether of the pyridine series. CH146546A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH146546T 1929-08-10

Publications (1)

Publication Number Publication Date
CH146546A true CH146546A (en) 1931-04-30

Family

ID=4402715

Family Applications (1)

Application Number Title Priority Date Filing Date
CH146546D CH146546A (en) 1929-08-10 1929-08-10 Process for the preparation of a basic ether of the pyridine series.

Country Status (1)

Country Link
CH (1) CH146546A (en)

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