CH140867A - Process for the comminution of animal components. - Google Patents

Process for the comminution of animal components.

Info

Publication number
CH140867A
CH140867A CH140867DA CH140867A CH 140867 A CH140867 A CH 140867A CH 140867D A CH140867D A CH 140867DA CH 140867 A CH140867 A CH 140867A
Authority
CH
Switzerland
Prior art keywords
comminution
components
animal components
extracted
fresh
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH140867A publication Critical patent/CH140867A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Description

  

  Verfahren zur Zerkleinerung tierischer Bestandteile.    Im Patent Nr. 128855 ist ein Verfahren  beschrieben zur Zerkleinerung weiblicher in  nersekretorischer Organe zwecks Herstellung  eines Produktes, aus dem die wirksamen Be  standteile mit guter Ausbeute extrahiert  werden können, dadurch gekennzeichnet,  dass man die frischen Organe, gegebenenfalls  unter Beigabe     wasserbindender    Mittel, auf  so tiefe Temperaturen abkühlt, dass sie er  starren und dieselben in diesem Zustand pul  verisiert.  



  Im Patent Nr. 139324 ist die Anwendung  dieser Arbeitsweise auf männliche Keimdrüsen  beschrieben.  



  Wie gefunden wurde, können in analoger  Weise auch     keimdrüsenhormonarme    tierische  Bestandteile, welche therapeutisch wirksame  Stoffe enthalten zerkleinert werden.  



  <I>Beispiel 1:</I>  500     gr    frische     Hypophysenvorderlappen     werden mit fester Kohlensäure vermischt  und nach einigem Stehen     vermahlen.    Die ge-    pulverte Masse kann zum Beispiel mit Al  kohol extrahiert werden.  



  <I>Beispiel 2:</I>  Frische Herzen oder Teile von     solchen     warmblütiger Tiere werden mit flüssigem       Stickstoff    gekühlt und gepulvert. Nach dem  Auftauen wird das Pulver z. Beispiel mit       vardünntem    Alkohol extrahiert.  



  <I>Beispiel 3:</I>  1 kg frische Rindermilz wird in kleine  Stücke zerschnitten und nach Zusatz von  4 kg     calciniertem    Natriumsulfat mit fester  Kohlensäure vermischt. Hierauf wird gemah  len und nun erschöpfend mit wässerigem  Aceton extrahiert. Die Lösung wird vom  Aceton befreit und mit Äther ausgeschüttelt.  In der wässerigen Lösung können die Ei  weisssubstanzen auf übliche Weise gefällt  werden. Nach dem     Verdünsten    des Wassers  bleibt ein sehr     zerfliessliches    gelbes Pulver  zurück, das     physiologisch        wn'ksanie    Substan  zen enthält.

        Nach dem gleichen Verfahren können  zum Beispiel Knochenmark,     Rindsblut,    Hirn  substanz     etc.    in frischem Zustand behandelt  werden.



  Process for the comminution of animal components. Patent No. 128855 describes a method for comminuting female organs in nersecretory for the purpose of producing a product from which the active ingredients can be extracted with good yield, characterized in that the fresh organs, optionally with the addition of water-binding agents, on so low temperatures so that they stare and pulverize them in this state.



  Patent No. 139324 describes the application of this technique to male gonads.



  As has been found, animal components which are low in germ gland hormones and which contain therapeutically active substances can also be comminuted in an analogous manner.



  <I> Example 1: </I> 500 gr of fresh anterior pituitary lobes are mixed with solid carbon dioxide and ground after standing for a while. The powdered mass can be extracted with alcohol, for example.



  <I> Example 2: </I> Fresh hearts or parts of such warm-blooded animals are cooled with liquid nitrogen and powdered. After thawing, the powder is z. Example extracted with diluted alcohol.



  <I> Example 3: </I> 1 kg of fresh beef spleen is cut into small pieces and, after adding 4 kg of calcined sodium sulfate, mixed with solid carbon dioxide. It is then milled and extracted exhaustively with aqueous acetone. The solution is freed from acetone and extracted with ether. The protein substances can be precipitated in the usual way in the aqueous solution. After the water has evaporated, a very deliquescent yellow powder remains, which physiologically contains wn'ksanie substances.

        Bone marrow, bovine blood, brain matter, etc., for example, can be treated in the fresh state using the same procedure.

Claims (1)

PATENTANSPRUCH: Verfahren zur Zerkleinerung keimdrüsen- hormonarmer tierischer Bestandteile, zwecks Herstellung eines Produktes, aus dein die wirksamen Bestandteile mit guter Ausbeute extrahiert werden können, dadurch gekenn zeichnet, dass man die frischen Bestandteile auf so tiefe Temperaturen abkühlt, dass sie erstarren und dieselben in diesem Zustand pulverisiert. UNTERANSPRUCH: Verfahren gemäss Patentanspruch, dadurch gekennzeichnet, dass die Pulverisierung unter Beigabe wasserbindender Mittel vorgenom men wird. PATENT CLAIM: Process for comminuting animal components with low levels of gonadal hormones for the purpose of manufacturing a product from which the active components can be extracted with good yield, characterized in that the fresh components are cooled to such low temperatures that they solidify and the same in this Powdered state. SUBClaim: Process according to claim, characterized in that the pulverization is carried out with the addition of water-binding agents.
CH140867D 1928-04-11 1928-04-11 Process for the comminution of animal components. CH140867A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH140867T 1928-04-11

Publications (1)

Publication Number Publication Date
CH140867A true CH140867A (en) 1930-06-30

Family

ID=4397843

Family Applications (1)

Application Number Title Priority Date Filing Date
CH140867D CH140867A (en) 1928-04-11 1928-04-11 Process for the comminution of animal components.

Country Status (1)

Country Link
CH (1) CH140867A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1028290B (en) * 1952-02-27 1958-04-17 Konink Ind Mij Voorheen Noury Process for the production of a cytostatic preparation
FR2399251A1 (en) * 1977-08-04 1979-03-02 Aesculapius Lab Chim Farma EXTRACTION PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDS FOR THERAPEUTIC USE FROM ANIMAL ORGANS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1028290B (en) * 1952-02-27 1958-04-17 Konink Ind Mij Voorheen Noury Process for the production of a cytostatic preparation
FR2399251A1 (en) * 1977-08-04 1979-03-02 Aesculapius Lab Chim Farma EXTRACTION PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDS FOR THERAPEUTIC USE FROM ANIMAL ORGANS

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