CA986937A - Process for the manufacture of benzyl pyrimidines - Google Patents

Process for the manufacture of benzyl pyrimidines

Info

Publication number
CA986937A
CA986937A CA185,979A CA185979A CA986937A CA 986937 A CA986937 A CA 986937A CA 185979 A CA185979 A CA 185979A CA 986937 A CA986937 A CA 986937A
Authority
CA
Canada
Prior art keywords
manufacture
benzyl pyrimidines
pyrimidines
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA185,979A
Other languages
English (en)
Inventor
Percy Manchand
Perry Rosen
Pius A. Wehrli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA986937A publication Critical patent/CA986937A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA185,979A 1972-12-21 1973-11-16 Process for the manufacture of benzyl pyrimidines Expired CA986937A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31750072A 1972-12-21 1972-12-21

Publications (1)

Publication Number Publication Date
CA986937A true CA986937A (en) 1976-04-06

Family

ID=23233931

Family Applications (1)

Application Number Title Priority Date Filing Date
CA185,979A Expired CA986937A (en) 1972-12-21 1973-11-16 Process for the manufacture of benzyl pyrimidines

Country Status (15)

Country Link
JP (1) JPS4988886A (uk)
AT (1) AT339315B (uk)
AU (1) AU476694B2 (uk)
BE (1) BE808870A (uk)
CA (1) CA986937A (uk)
CH (1) CH592065A5 (uk)
DE (1) DE2363533A1 (uk)
DK (1) DK135531B (uk)
FR (1) FR2211463B1 (uk)
GB (1) GB1411170A (uk)
HU (1) HU169082B (uk)
IL (1) IL43658A (uk)
NL (1) NL7317484A (uk)
PH (1) PH12708A (uk)
ZA (1) ZA738760B (uk)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122146C (uk) * 1960-09-02
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
GB1407971A (en) * 1971-04-16 1975-10-01 Wellcome Found 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor
BE792096A (fr) * 1971-12-01 1973-05-30 Hoffmann La Roche Nouvelles benzylpyrimidines
BE795023A (fr) * 1972-02-07 1973-08-06 Hoffmann La Roche Nouvelles benzylpyrimidines

Also Published As

Publication number Publication date
IL43658A (en) 1976-12-31
FR2211463A1 (uk) 1974-07-19
IL43658A0 (en) 1974-03-14
BE808870A (fr) 1974-06-20
ZA738760B (en) 1974-08-28
DK135531C (uk) 1977-10-10
PH12708A (en) 1979-07-20
ATA1070773A (de) 1977-02-15
AT339315B (de) 1977-10-10
CH592065A5 (uk) 1977-10-14
DE2363533A1 (de) 1974-06-27
GB1411170A (en) 1975-10-29
JPS4988886A (uk) 1974-08-24
DK135531B (da) 1977-05-16
AU476694B2 (en) 1976-09-30
HU169082B (uk) 1976-09-28
NL7317484A (uk) 1974-06-25
FR2211463B1 (uk) 1979-05-11
AU6275573A (en) 1975-05-22

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