CA978519A - Derivatives of polyene macrolide antiobiotics - Google Patents

Derivatives of polyene macrolide antiobiotics

Info

Publication number
CA978519A
CA978519A CA142,611A CA142611A CA978519A CA 978519 A CA978519 A CA 978519A CA 142611 A CA142611 A CA 142611A CA 978519 A CA978519 A CA 978519A
Authority
CA
Canada
Prior art keywords
antiobiotics
derivatives
polyene macrolide
macrolide
polyene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA142,611A
Other languages
English (en)
Other versions
CA142611S (en
Inventor
Witold S. Mechlinski
Carl P. Schaffner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers Research and Educational Foundation
Original Assignee
Rutgers Research and Educational Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers Research and Educational Foundation filed Critical Rutgers Research and Educational Foundation
Priority to CA211,660A priority Critical patent/CA979435A/en
Application granted granted Critical
Publication of CA978519A publication Critical patent/CA978519A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/16—Diazomethane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA142,611A 1971-06-07 1972-05-19 Derivatives of polyene macrolide antiobiotics Expired CA978519A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA211,660A CA979435A (en) 1971-06-07 1974-10-17 Derivatives of polyene macrolide antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/152,460 US3945993A (en) 1971-06-07 1971-06-07 Derivatives of polyene macrolide antibiotics

Publications (1)

Publication Number Publication Date
CA978519A true CA978519A (en) 1975-11-25

Family

ID=22543022

Family Applications (1)

Application Number Title Priority Date Filing Date
CA142,611A Expired CA978519A (en) 1971-06-07 1972-05-19 Derivatives of polyene macrolide antiobiotics

Country Status (13)

Country Link
US (1) US3945993A (ja)
JP (1) JPS5627519B1 (ja)
AR (1) AR193264A1 (ja)
BE (1) BE784207A (ja)
CA (1) CA978519A (ja)
CH (1) CH580642A5 (ja)
DE (1) DE2226338A1 (ja)
FR (1) FR2140407B1 (ja)
GB (1) GB1386325A (ja)
IE (1) IE36381B1 (ja)
NL (1) NL7207700A (ja)
NO (1) NO139174C (ja)
SE (1) SE415020B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399139A (en) * 1972-07-24 1975-06-25 Prodotti Antibiotici Spa Alkyl esters of polyene antibiotics
DE2417993C2 (de) * 1974-04-11 1982-07-01 Leningradskij naučno-issledovatel'skij institut antibiotikov, Leningrad Polyenmacrolidantibiotica-Komplexe, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2609611A1 (de) * 1975-03-13 1976-09-23 Ciba Geigy Ag Verfahren zur herstellung eines neuen antibiotikums
US4035567A (en) * 1975-10-21 1977-07-12 E. R. Squibb & Sons, Inc. Process for producing the methyl ester of amphotericin B
US4041232A (en) * 1976-02-23 1977-08-09 E. R. Squibb & Sons, Inc. Amphotericin B methyl ester salts
DE2706156C3 (de) * 1977-02-14 1981-08-20 Vsesojuznyj naučno-issledovatel'skij technologičeskij institut antibiotikov i fermentov medicinskogo naznačenija, Leningrad N,N,N-Trimethylderivate amphoterer, antimykotischer Polyenantibiotika und Verfahren zu deren Herstellung
GB1566330A (en) * 1977-02-16 1980-04-30 Farmaceutici Italia Anthracycline glycosides
US4144328A (en) * 1977-02-28 1979-03-13 Vainshtein Viktor A N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition
ZA807892B (en) * 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
US4308375A (en) * 1980-10-06 1981-12-29 E. R. Squibb & Sons, Inc. Method for purifying water-insoluble polyene antibiotics
US4536494A (en) * 1983-11-17 1985-08-20 Carter A Franklin Animal feed method employing natamycin
US4600706A (en) * 1983-11-17 1986-07-15 Carter A F Anti-fungal feed compositions containing natamycin
EP0350164A3 (en) * 1988-06-13 1991-07-24 Beecham Group Plc Amphotericin derivatives
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
CN101081860B (zh) * 2006-06-01 2010-04-14 上海医药工业研究院 多烯类抗生素双酯化合物
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
CN110669087B (zh) * 2018-07-02 2023-03-31 上海医药工业研究院 两性霉素b肽衍生物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2908612A (en) * 1957-03-25 1959-10-13 Olin Mathieson Amphotericin a and its salts
US3244590A (en) * 1960-12-23 1966-04-05 Rutgers Res And Educational Fo Polyenic compounds and procedures related thereto
US3777018A (en) * 1967-03-31 1973-12-04 Schmid Inc Julius Compositions containing polyenic macro-lide and aryl derivative of aliphatic acid and method for treating hyper-lipidaemia

Also Published As

Publication number Publication date
GB1386325A (en) 1975-03-05
NL7207700A (ja) 1972-12-11
NO139174C (no) 1979-01-17
FR2140407B1 (ja) 1975-08-08
JPS5627519B1 (ja) 1981-06-25
IE36381B1 (en) 1976-10-27
SE415020B (sv) 1980-09-01
BE784207A (fr) 1972-11-30
CH580642A5 (ja) 1976-10-15
DE2226338A1 (de) 1973-01-04
AR193264A1 (es) 1973-04-11
IE36381L (en) 1972-12-07
US3945993A (en) 1976-03-23
FR2140407A1 (ja) 1973-01-19
NO139174B (no) 1978-10-09

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