CA975755A - Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof - Google Patents

Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof

Info

Publication number
CA975755A
CA975755A CA141,366A CA141366A CA975755A CA 975755 A CA975755 A CA 975755A CA 141366 A CA141366 A CA 141366A CA 975755 A CA975755 A CA 975755A
Authority
CA
Canada
Prior art keywords
preparation
well
acid esters
nitric acid
pregnane series
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA141,366A
Other languages
English (en)
Other versions
CA141366S (en
Inventor
Jozsef Toth
Sandor Holly
Eva Czajlik
Tamas Szen
Anna Boor
Katalin Gorgenyi
Mate Kovatsits
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of CA975755A publication Critical patent/CA975755A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA141,366A 1971-05-07 1972-05-05 Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof Expired CA975755A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI429A HU164115B (da) 1971-05-07 1971-05-07

Publications (1)

Publication Number Publication Date
CA975755A true CA975755A (en) 1975-10-07

Family

ID=11000864

Family Applications (1)

Application Number Title Priority Date Filing Date
CA141,366A Expired CA975755A (en) 1971-05-07 1972-05-05 Nitric acid esters of 21-alcohols belonging to the pregnane series as well as a process for the preparation thereof

Country Status (15)

Country Link
JP (1) JPS5330707B1 (da)
AT (1) AT316767B (da)
AU (1) AU469581B2 (da)
CA (1) CA975755A (da)
CS (2) CS171258B2 (da)
DD (1) DD98668A5 (da)
DE (1) DE2222491C3 (da)
ES (1) ES402230A1 (da)
FR (1) FR2143664A1 (da)
HU (1) HU164115B (da)
NL (1) NL7206134A (da)
PL (1) PL75494B1 (da)
SE (2) SE385590B (da)
SU (1) SU493963A3 (da)
YU (1) YU34701B (da)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707984A (en) * 1995-12-08 1998-01-13 G. D. Searle & Co. Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
US20100041633A1 (en) 2007-02-05 2010-02-18 Nicox S.A. Nitric oxide releasing steroids
US8716268B2 (en) * 2010-06-07 2014-05-06 Chao Liu Nitrate esters of corticoid compounds useful as diuretics

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707984A (en) * 1995-12-08 1998-01-13 G. D. Searle & Co. Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US6197762B1 (en) 1996-03-22 2001-03-06 Nitromed, Inc. Nitrosated and nitrosylated steroids compositions, and methods for treating respiratory disorders
USRE37116E1 (en) * 1996-03-22 2001-03-27 Nitromed, Inc. Nitrosated and nitrosylated compounds, and compositions and their use for treating respiratory disorders
US6579863B1 (en) 1996-03-22 2003-06-17 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US7160920B2 (en) 1996-03-22 2007-01-09 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US7345037B2 (en) 1996-03-22 2008-03-18 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US8334279B2 (en) 2008-05-28 2012-12-18 Validus Genetics Non-hormonal steroid modulators of NF-κB for treatment of disease
US10206933B2 (en) 2008-05-28 2019-02-19 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kB for treatment of disease
US8673887B2 (en) 2008-05-28 2014-03-18 Reveragen Biopharma, Inc Non-hormonal steroid modulators of NF-kB for treatment of disease
US11833159B2 (en) 2008-05-28 2023-12-05 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kB for treatment of disease
US9434758B2 (en) 2008-05-28 2016-09-06 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US9649320B2 (en) 2008-05-28 2017-05-16 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10857161B2 (en) 2008-05-28 2020-12-08 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kB for treatment of disease
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10000525B2 (en) 2010-04-05 2018-06-19 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11690853B2 (en) 2015-06-29 2023-07-04 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κβ for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US11471471B2 (en) 2019-03-07 2022-10-18 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Also Published As

Publication number Publication date
YU34701B (en) 1979-12-31
NL7206134A (da) 1972-11-09
AU469581B2 (en) 1976-02-19
HU164115B (da) 1973-12-28
CS171259B2 (da) 1976-10-29
FR2143664B1 (da) 1976-07-02
DE2222491C3 (de) 1978-05-03
ES402230A1 (es) 1975-03-16
SE7503290L (da) 1975-03-21
DD98668A5 (da) 1973-07-05
DE2222491B2 (de) 1977-09-29
FR2143664A1 (en) 1973-02-09
PL75494B1 (da) 1974-12-31
CS171258B2 (da) 1976-10-29
YU111772A (en) 1979-07-10
SE385590B (sv) 1976-07-12
AT316767B (de) 1974-07-25
JPS5330707B1 (da) 1978-08-29
SU493963A3 (ru) 1975-11-28
AU4172272A (en) 1973-11-08
DE2222491A1 (de) 1972-11-16

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