CA972745A - MANUFACTURE OF .alpha.-6-DEOXYTETRACYCLINES - Google Patents
MANUFACTURE OF .alpha.-6-DEOXYTETRACYCLINESInfo
- Publication number
- CA972745A CA972745A CA124,593A CA124593A CA972745A CA 972745 A CA972745 A CA 972745A CA 124593 A CA124593 A CA 124593A CA 972745 A CA972745 A CA 972745A
- Authority
- CA
- Canada
- Prior art keywords
- deoxytetracyclines
- alpha
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10209470A | 1970-12-28 | 1970-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA972745A true CA972745A (en) | 1975-08-12 |
Family
ID=22288092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA124,593A Expired CA972745A (en) | 1970-12-28 | 1971-10-06 | MANUFACTURE OF .alpha.-6-DEOXYTETRACYCLINES |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US3795707A (no) |
| JP (1) | JPS535299B1 (no) |
| BE (1) | BE777357A (no) |
| CA (1) | CA972745A (no) |
| CH (1) | CH567456A5 (no) |
| DE (1) | DE2117442B2 (no) |
| DK (1) | DK139576B (no) |
| ES (1) | ES391290A1 (no) |
| FI (1) | FI53302B (no) |
| FR (1) | FR2120866A5 (no) |
| GB (1) | GB1370797A (no) |
| IE (1) | IE35673B1 (no) |
| IL (1) | IL37883A (no) |
| NL (1) | NL7113277A (no) |
| NO (1) | NO133102C (no) |
| SE (1) | SE373836B (no) |
| ZA (1) | ZA716574B (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3906043A (en) * | 1969-06-12 | 1975-09-16 | Israel Marcus | Water-soluble tetracyclines |
| US4061676A (en) * | 1970-07-03 | 1977-12-06 | Ivan Villax | Recovery of doxycycline and products thereof |
| DK386784A (da) * | 1983-08-17 | 1985-02-18 | Hovione Int Ltd | Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner |
| US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| EP2311797A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| WO2003079984A2 (en) | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2298323A3 (en) * | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH365484A (fr) * | 1956-05-28 | 1962-11-15 | American Cyanamid Co | Procédé de préparation d'une substance antibiotique |
| FR1430859A (no) * | 1960-05-23 | 1966-05-25 | ||
| US3397231A (en) * | 1967-04-12 | 1968-08-13 | Pfizer & Co C | Refining of alpha-6-deoxy-5-oxytetracycline |
| CA945546A (en) * | 1970-07-03 | 1974-04-16 | Ivan Villax | Recovery of doxycycline and products thereof |
-
1970
- 1970-12-28 US US00102094A patent/US3795707A/en not_active Expired - Lifetime
-
1971
- 1971-04-07 DK DK166871AA patent/DK139576B/da unknown
- 1971-04-08 DE DE2117442A patent/DE2117442B2/de not_active Withdrawn
- 1971-04-13 SE SE7104704A patent/SE373836B/xx unknown
- 1971-04-14 NO NO1387/71A patent/NO133102C/no unknown
- 1971-05-18 ES ES391290A patent/ES391290A1/es not_active Expired
- 1971-06-03 FI FI1538/71A patent/FI53302B/fi active
- 1971-09-28 IE IE1209/71A patent/IE35673B1/xx unknown
- 1971-09-28 NL NL7113277A patent/NL7113277A/xx unknown
- 1971-09-30 ZA ZA716574A patent/ZA716574B/xx unknown
- 1971-10-06 JP JP7797071A patent/JPS535299B1/ja active Pending
- 1971-10-06 CA CA124,593A patent/CA972745A/en not_active Expired
- 1971-10-08 IL IL37883A patent/IL37883A/en unknown
- 1971-10-29 GB GB5036671A patent/GB1370797A/en not_active Expired
- 1971-12-10 CH CH1810371A patent/CH567456A5/xx not_active IP Right Cessation
- 1971-12-24 FR FR7146558A patent/FR2120866A5/fr not_active Expired
- 1971-12-28 BE BE777357A patent/BE777357A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK139576C (no) | 1979-08-27 |
| BE777357A (fr) | 1972-04-17 |
| ES391290A1 (es) | 1972-01-16 |
| NO133102C (no) | 1976-03-10 |
| US3795707A (en) | 1974-03-05 |
| DK139576B (da) | 1979-03-12 |
| JPS535299B1 (no) | 1978-02-25 |
| IE35673B1 (en) | 1976-04-14 |
| IE35673L (en) | 1972-06-28 |
| NL7113277A (no) | 1972-06-30 |
| SE373836B (no) | 1975-02-17 |
| NO133102B (no) | 1975-12-01 |
| IL37883A0 (en) | 1971-12-29 |
| ZA716574B (en) | 1973-05-30 |
| DE2117442B2 (de) | 1980-06-04 |
| FI53302B (no) | 1977-12-30 |
| GB1370797A (en) | 1974-10-16 |
| IL37883A (en) | 1974-12-31 |
| CH567456A5 (no) | 1975-10-15 |
| DE2117442A1 (de) | 1972-07-27 |
| FR2120866A5 (no) | 1972-08-18 |
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