CA949069A - Thiadiazole products and process - Google Patents

Thiadiazole products and process

Info

Publication number
CA949069A
CA949069A CA051,320A CA51320A CA949069A CA 949069 A CA949069 A CA 949069A CA 51320 A CA51320 A CA 51320A CA 949069 A CA949069 A CA 949069A
Authority
CA
Canada
Prior art keywords
thiadiazole
products
thiadiazole products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA051,320A
Other languages
English (en)
Inventor
Dennis M. Mulvey
Leonard M. Weinstock
Roger J. Tull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Charles E Frosst and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles E Frosst and Co filed Critical Charles E Frosst and Co
Priority to CA096,737A priority Critical patent/CA985698A/en
Priority to CA122,028A priority patent/CA954863A/en
Priority to CA126,381A priority patent/CA945165A/en
Priority to CA134,570A priority patent/CA940929A/en
Priority claimed from US00370994A external-priority patent/US3812182A/en
Priority claimed from US05/417,301 external-priority patent/US3962338A/en
Priority claimed from US425912A external-priority patent/US3892744A/en
Priority to CA192,916A priority patent/CA981271A/en
Application granted granted Critical
Publication of CA949069A publication Critical patent/CA949069A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA051,320A 1968-05-22 1969-05-12 Thiadiazole products and process Expired CA949069A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA096,737A CA985698A (en) 1968-05-22 1970-12-17 Thiadiazole products and process
CA122,028A CA954863A (en) 1968-05-22 1971-09-02 Preparation of 3-substituted-4-chloro-1,2,5-thiadiazole
CA126,381A CA945165A (en) 1968-05-22 1971-10-28 Thiadiazole products and process
CA134,570A CA940929A (en) 1969-04-21 1972-02-11 Thiadiazole process
CA192,916A CA981271A (en) 1968-05-22 1974-02-19 Thiadiazole products and process

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US73133368A 1968-05-22 1968-05-22
US81808669A 1969-04-21 1969-04-21
US81809069A 1969-04-21 1969-04-21
US81847469A 1969-04-21 1969-04-21
US17223271A 1971-08-16 1971-08-16
US17223171A 1971-08-16 1971-08-16
US17223071A 1971-08-16 1971-08-16
US17914771A 1971-09-09 1971-09-09
US17914571A 1971-09-09 1971-09-09
US28401372A 1972-08-25 1972-08-25
US00370994A US3812182A (en) 1968-05-22 1973-06-18 S-bis-(2-lower alkyl amino hydroxy-methylethoxy)-methanes
US05/417,301 US3962338A (en) 1968-05-22 1973-11-19 Novel methods and compounds employed therein
US425912A US3892744A (en) 1968-05-22 1973-12-18 Process for preparing 4-{8 3-(substituted amino)-2-hydroxypropoxy{9 -1,2,5-thiadiazoles

Publications (1)

Publication Number Publication Date
CA949069A true CA949069A (en) 1974-06-11

Family

ID=27584550

Family Applications (1)

Application Number Title Priority Date Filing Date
CA051,320A Expired CA949069A (en) 1968-05-22 1969-05-12 Thiadiazole products and process

Country Status (10)

Country Link
US (3) US3657237A (xx)
AT (3) AT289788B (xx)
BE (1) BE733387A (xx)
CA (1) CA949069A (xx)
CH (5) CH560710A5 (xx)
DE (1) DE1925955A1 (xx)
FR (2) FR2039306B1 (xx)
GB (2) GB1267328A (xx)
NL (1) NL153189B (xx)
SE (2) SE388613B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892744A (en) * 1968-05-22 1975-07-01 Merck & Co Inc Process for preparing 4-{8 3-(substituted amino)-2-hydroxypropoxy{9 -1,2,5-thiadiazoles
JPS4913176A (xx) * 1972-06-03 1974-02-05
US3891639A (en) * 1973-04-19 1975-06-24 Merck Sharp & Dohme 4-{8 3-Amino-2-acyloxypropoxy{9 -1,2,5-thiadiazole compounds
US4011217A (en) * 1973-04-19 1977-03-08 Merck Sharp & Dohme (I.A.) Corporation 4-(3-amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds
DE2609486A1 (de) * 1975-08-07 1977-05-12 Hoffmann La Roche Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung
US4097490A (en) * 1975-09-25 1978-06-27 Merck & Co., Inc. Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane
US4119718A (en) * 1977-05-02 1978-10-10 Merck & Co., Inc. 3-Amino-2-oxy-propoxy-substituted isothiazoles
ZA805250B (en) * 1979-09-04 1981-09-30 Bristol Myers Co Chemical compounds
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
AU540656B2 (en) * 1980-02-19 1984-11-29 Merck & Co., Inc. S-(-)-1-(tert-butylamino-3((4-morpholino-1,2,5-thiadiazol-3- yl)-oxy)-2-propanol pamoate
US4550117A (en) * 1982-07-26 1985-10-29 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines, derivatives thereof, having anti-hypertensive activity
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
US4644006A (en) * 1984-06-22 1987-02-17 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
FI82240C (fi) * 1988-10-20 1991-02-11 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt vaerdefullt s-timolol-hemihydrat.
US5320839A (en) * 1991-10-11 1994-06-14 Alcon Laboratories, Inc. Topical ophthalmic compositions comprising 4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazoles and methods for their use
US5523301A (en) * 1994-08-05 1996-06-04 Merck & Co., Inc. Optic nerve health
US5821370A (en) * 1994-10-24 1998-10-13 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US6258350B1 (en) 1999-01-20 2001-07-10 Alcon Manufacturing, Ltd. Sustained release ophthalmic formulation
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
EP1609837B1 (en) * 2003-02-05 2016-11-02 Hitachi Chemical Company, Ltd. Friction material composition and friction material therefrom
US7090548B1 (en) * 2005-02-03 2006-08-15 International Business Machines Corporation Method of using a linear propulsor array for propulsion and navigation
US9782488B2 (en) 2007-03-12 2017-10-10 Nektar Therapeutics Oligomer-beta blocker conjugates
EP2050441A1 (en) * 2007-10-19 2009-04-22 Université Victor Segalen Bordeaux 2 Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US8987262B2 (en) 2007-10-19 2015-03-24 Universite de Bordeaux Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US20110092507A1 (en) * 2009-10-20 2011-04-21 Chin-Tsai Fan Process for preparing R-(+)-3-morpholino-4-(3- tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2964530A (en) * 1958-05-02 1960-12-13 Sterling Drug Inc 3-alkyl-4-hydroxymethyl-4-alkyloxazolidines

Also Published As

Publication number Publication date
CH544119A (de) 1973-12-28
BE733387A (xx) 1969-11-21
SE7410837L (xx) 1974-08-27
US3781284A (en) 1973-12-25
DE1925955A1 (de) 1970-10-29
FR2116583A1 (xx) 1972-07-13
SE388613B (sv) 1976-10-11
CH553214A (de) 1974-08-30
CH554887A (de) 1974-10-15
FR2116583B1 (xx) 1982-03-19
NL153189B (nl) 1977-05-16
FR2039306A1 (xx) 1971-01-15
GB1267328A (en) 1972-03-15
US3766180A (en) 1973-10-16
US3657237A (en) 1972-04-18
SE421001B (sv) 1981-11-16
GB1264558A (xx) 1972-02-23
CH560710A5 (xx) 1975-04-15
AT289788B (de) 1971-05-10
FR2039306B1 (xx) 1974-03-22
AT305229B (de) 1973-02-12
CH543478A (de) 1973-12-14
AT294830B (de) 1971-12-10
NL6907872A (xx) 1969-11-25

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