SE388613B - Mellanprodukt till anvendning for framstellning av 1,2,5-tiadiazolforeningar med beta-adrenergiska blockeringsegenskaper - Google Patents
Mellanprodukt till anvendning for framstellning av 1,2,5-tiadiazolforeningar med beta-adrenergiska blockeringsegenskaperInfo
- Publication number
- SE388613B SE388613B SE7213230A SE1323072A SE388613B SE 388613 B SE388613 B SE 388613B SE 7213230 A SE7213230 A SE 7213230A SE 1323072 A SE1323072 A SE 1323072A SE 388613 B SE388613 B SE 388613B
- Authority
- SE
- Sweden
- Prior art keywords
- preparation
- alkyl
- beta
- blocking properties
- adrenergic blocking
- Prior art date
Links
- 150000004868 1,2,5-thiadiazoles Chemical class 0.000 title 1
- 230000000903 blocking effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 morpholino, piperidyl Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000002917 oxazolidines Chemical class 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000004867 thiadiazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73133368A | 1968-05-22 | 1968-05-22 | |
US81809069A | 1969-04-21 | 1969-04-21 | |
US81847469A | 1969-04-21 | 1969-04-21 | |
US81808669A | 1969-04-21 | 1969-04-21 | |
US17223271A | 1971-08-16 | 1971-08-16 | |
US17223071A | 1971-08-16 | 1971-08-16 | |
US17223171A | 1971-08-16 | 1971-08-16 | |
US17914571A | 1971-09-09 | 1971-09-09 | |
US17914771A | 1971-09-09 | 1971-09-09 | |
US28401372A | 1972-08-25 | 1972-08-25 | |
US00370994A US3812182A (en) | 1968-05-22 | 1973-06-18 | S-bis-(2-lower alkyl amino hydroxy-methylethoxy)-methanes |
US05/417,301 US3962338A (en) | 1968-05-22 | 1973-11-19 | Novel methods and compounds employed therein |
US425912A US3892744A (en) | 1968-05-22 | 1973-12-18 | Process for preparing 4-{8 3-(substituted amino)-2-hydroxypropoxy{9 -1,2,5-thiadiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
SE388613B true SE388613B (sv) | 1976-10-11 |
Family
ID=27584550
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7213230A SE388613B (sv) | 1968-05-22 | 1969-05-21 | Mellanprodukt till anvendning for framstellning av 1,2,5-tiadiazolforeningar med beta-adrenergiska blockeringsegenskaper |
SE7410837A SE421001B (sv) | 1968-05-22 | 1974-08-27 | Mellanprodukt till anvendning for framstellning av 1,2,5-tiadiazolforeningar och forfarande for framstellning av denna |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7410837A SE421001B (sv) | 1968-05-22 | 1974-08-27 | Mellanprodukt till anvendning for framstellning av 1,2,5-tiadiazolforeningar och forfarande for framstellning av denna |
Country Status (10)
Country | Link |
---|---|
US (3) | US3657237A (sv) |
AT (3) | AT294830B (sv) |
BE (1) | BE733387A (sv) |
CA (1) | CA949069A (sv) |
CH (5) | CH560710A5 (sv) |
DE (1) | DE1925955A1 (sv) |
FR (2) | FR2039306B1 (sv) |
GB (2) | GB1264558A (sv) |
NL (1) | NL153189B (sv) |
SE (2) | SE388613B (sv) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892744A (en) * | 1968-05-22 | 1975-07-01 | Merck & Co Inc | Process for preparing 4-{8 3-(substituted amino)-2-hydroxypropoxy{9 -1,2,5-thiadiazoles |
JPS4913176A (sv) * | 1972-06-03 | 1974-02-05 | ||
US4011217A (en) * | 1973-04-19 | 1977-03-08 | Merck Sharp & Dohme (I.A.) Corporation | 4-(3-amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds |
US3891639A (en) * | 1973-04-19 | 1975-06-24 | Merck Sharp & Dohme | 4-{8 3-Amino-2-acyloxypropoxy{9 -1,2,5-thiadiazole compounds |
DE2609486A1 (de) * | 1975-08-07 | 1977-05-12 | Hoffmann La Roche | Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung |
US4097490A (en) * | 1975-09-25 | 1978-06-27 | Merck & Co., Inc. | Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane |
US4119718A (en) * | 1977-05-02 | 1978-10-10 | Merck & Co., Inc. | 3-Amino-2-oxy-propoxy-substituted isothiazoles |
DK160611C (da) * | 1979-09-04 | 1991-09-16 | Bristol Myers Squibb Co | Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider |
ZA805250B (en) * | 1979-09-04 | 1981-09-30 | Bristol Myers Co | Chemical compounds |
NZ196227A (en) * | 1980-02-19 | 1984-09-28 | Merck & Co Inc | 1,2,5-thiadiazole derivative and ophthalmic compositions |
US4550117A (en) * | 1982-07-26 | 1985-10-29 | Merck & Co., Inc. | 3-Cycloalkylamino-2-OR-propoxycyanopyridines, derivatives thereof, having anti-hypertensive activity |
US4794111A (en) * | 1984-05-23 | 1988-12-27 | Bayer Aktiengesellschaft | Dihydropyridine preparations containing β-blockers |
US4644006A (en) * | 1984-06-22 | 1987-02-17 | Bristol-Myers Company | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity |
FI82240C (sv) * | 1988-10-20 | 1991-02-11 | Huhtamaeki Oy | Förfarande för framställning av farmakologiskt värdefullt S-timolol-he mihydrat |
US5320839A (en) * | 1991-10-11 | 1994-06-14 | Alcon Laboratories, Inc. | Topical ophthalmic compositions comprising 4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazoles and methods for their use |
US5523301A (en) * | 1994-08-05 | 1996-06-04 | Merck & Co., Inc. | Optic nerve health |
US5672709A (en) * | 1994-10-24 | 1997-09-30 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
US6258350B1 (en) | 1999-01-20 | 2001-07-10 | Alcon Manufacturing, Ltd. | Sustained release ophthalmic formulation |
US7001615B1 (en) | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
TWI293087B (en) * | 2003-02-05 | 2008-02-01 | Hitachi Chemical Co Ltd | Friction material composition and friction material using thereof |
US7090548B1 (en) * | 2005-02-03 | 2006-08-15 | International Business Machines Corporation | Method of using a linear propulsor array for propulsion and navigation |
WO2008112287A1 (en) | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
EP2050441A1 (en) | 2007-10-19 | 2009-04-22 | Université Victor Segalen Bordeaux 2 | Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas |
US8987262B2 (en) | 2007-10-19 | 2015-03-24 | Universite de Bordeaux | Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas |
US20110092507A1 (en) * | 2009-10-20 | 2011-04-21 | Chin-Tsai Fan | Process for preparing R-(+)-3-morpholino-4-(3- tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2964530A (en) * | 1958-05-02 | 1960-12-13 | Sterling Drug Inc | 3-alkyl-4-hydroxymethyl-4-alkyloxazolidines |
-
1969
- 1969-04-21 US US818474A patent/US3657237A/en not_active Expired - Lifetime
- 1969-05-12 CA CA051,320A patent/CA949069A/en not_active Expired
- 1969-05-19 GB GB1264558D patent/GB1264558A/en not_active Expired
- 1969-05-19 GB GB52518/70A patent/GB1267328A/en not_active Expired
- 1969-05-21 DE DE19691925955 patent/DE1925955A1/de active Pending
- 1969-05-21 AT AT1063570A patent/AT294830B/de not_active IP Right Cessation
- 1969-05-21 AT AT483869A patent/AT289788B/de active
- 1969-05-21 SE SE7213230A patent/SE388613B/sv unknown
- 1969-05-21 AT AT1063470A patent/AT305229B/de not_active IP Right Cessation
- 1969-05-21 CH CH776169A patent/CH560710A5/xx not_active IP Right Cessation
- 1969-05-21 CH CH369872A patent/CH553214A/xx not_active IP Right Cessation
- 1969-05-21 CH CH369772A patent/CH554887A/xx not_active IP Right Cessation
- 1969-05-21 CH CH369972A patent/CH544119A/de not_active IP Right Cessation
- 1969-05-21 CH CH584972A patent/CH543478A/de not_active IP Right Cessation
- 1969-05-21 BE BE733387D patent/BE733387A/xx not_active IP Right Cessation
- 1969-05-22 FR FR6916768A patent/FR2039306B1/fr not_active Expired
- 1969-05-22 NL NL696907872A patent/NL153189B/xx not_active IP Right Cessation
-
1971
- 1971-08-16 US US00172230A patent/US3766180A/en not_active Expired - Lifetime
- 1971-08-16 US US00172232A patent/US3781284A/en not_active Expired - Lifetime
- 1971-12-09 FR FR7144211A patent/FR2116583B1/fr not_active Expired
-
1974
- 1974-08-27 SE SE7410837A patent/SE421001B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH544119A (de) | 1973-12-28 |
AT305229B (de) | 1973-02-12 |
GB1264558A (sv) | 1972-02-23 |
FR2039306A1 (sv) | 1971-01-15 |
US3766180A (en) | 1973-10-16 |
GB1267328A (en) | 1972-03-15 |
CH553214A (de) | 1974-08-30 |
FR2116583A1 (sv) | 1972-07-13 |
CA949069A (en) | 1974-06-11 |
SE421001B (sv) | 1981-11-16 |
SE7410837L (sv) | 1974-08-27 |
DE1925955A1 (de) | 1970-10-29 |
NL153189B (nl) | 1977-05-16 |
US3781284A (en) | 1973-12-25 |
AT289788B (de) | 1971-05-10 |
AT294830B (de) | 1971-12-10 |
CH554887A (de) | 1974-10-15 |
NL6907872A (sv) | 1969-11-25 |
FR2116583B1 (sv) | 1982-03-19 |
US3657237A (en) | 1972-04-18 |
FR2039306B1 (sv) | 1974-03-22 |
CH560710A5 (sv) | 1975-04-15 |
CH543478A (de) | 1973-12-14 |
BE733387A (sv) | 1969-11-21 |
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