CA3245542A1 - Piperazine substitute indazole compounds used as paracetamol inhibitors - Google Patents

Piperazine substitute indazole compounds used as paracetamol inhibitors

Info

Publication number
CA3245542A1
CA3245542A1 CA3245542A CA3245542A CA3245542A1 CA 3245542 A1 CA3245542 A1 CA 3245542A1 CA 3245542 A CA3245542 A CA 3245542A CA 3245542 A CA3245542 A CA 3245542A CA 3245542 A1 CA3245542 A1 CA 3245542A1
Authority
CA
Canada
Prior art keywords
formula
compound
cancer
pharmaceutically acceptable
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3245542A
Other languages
English (en)
French (fr)
Inventor
Paul A. Barsanti
Michael Patrick Dillon
Firoz Ali Jaipuri
Ying-Zi Xu
Xin Linghu
Monah ABED
Original Assignee
Ideaya Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ideaya Biosciences Inc filed Critical Ideaya Biosciences Inc
Publication of CA3245542A1 publication Critical patent/CA3245542A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3245542A 2022-03-23 2023-03-22 Piperazine substitute indazole compounds used as paracetamol inhibitors Pending CA3245542A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263322994P 2022-03-23 2022-03-23
US63/322,994 2022-03-23
PCT/US2023/064825 WO2023183850A1 (en) 2022-03-23 2023-03-22 Piperazine substituted indazole compounds as inhibitors of parg

Publications (1)

Publication Number Publication Date
CA3245542A1 true CA3245542A1 (en) 2023-09-28

Family

ID=86053625

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3245542A Pending CA3245542A1 (en) 2022-03-23 2023-03-22 Piperazine substitute indazole compounds used as paracetamol inhibitors

Country Status (27)

Country Link
US (2) US12269820B2 (enExample)
EP (2) EP4496795B1 (enExample)
JP (1) JP7783436B2 (enExample)
KR (1) KR20240165402A (enExample)
CN (1) CN119255994A (enExample)
AR (1) AR128846A1 (enExample)
AU (1) AU2023239344A1 (enExample)
CA (1) CA3245542A1 (enExample)
CL (1) CL2024002805A1 (enExample)
CO (1) CO2024012798A2 (enExample)
CR (1) CR20240391A (enExample)
DK (1) DK4496795T3 (enExample)
DO (1) DOP2024000187A (enExample)
ES (1) ES3070012T3 (enExample)
FI (1) FI4496795T3 (enExample)
HR (1) HRP20260714T1 (enExample)
IL (1) IL315722A (enExample)
LT (1) LT4496795T (enExample)
MA (1) MA69135B1 (enExample)
MX (1) MX2024011545A (enExample)
PE (1) PE20251690A1 (enExample)
PL (1) PL4496795T3 (enExample)
PT (1) PT4496795T (enExample)
RS (1) RS68230B1 (enExample)
SM (1) SMT202600201T1 (enExample)
TW (1) TW202345809A (enExample)
WO (1) WO2023183850A1 (enExample)

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PL4496795T3 (pl) 2022-03-23 2026-07-20 Ideaya Biosciences, Inc. Związki indazolowe podstawione piperazyną jako inhibitory parg
AU2024253809A1 (en) * 2023-04-05 2025-10-16 Ideaya Biosciences, Inc. Combination therapy comprising a parg inhibitor and a topoisomerase inhibitor for treating cancer
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WO2025064750A1 (en) * 2023-09-20 2025-03-27 Ideaya Biosciences, Inc. Combination therapy with a parg inhibitor
WO2025082231A1 (zh) * 2023-10-20 2025-04-24 上海璎黎药业有限公司 一种杂芳环磺酰胺结构化合物、其药物组合物及应用
WO2025087941A1 (en) 2023-10-23 2025-05-01 Universite De Geneve Parg inhibitors in combination with parp inhibitors and uses thereof
CN122249439A (zh) 2023-10-26 2026-06-19 上海齐鲁制药研究中心有限公司 Parg抑制剂
WO2026022150A1 (en) 2024-07-22 2026-01-29 Forx Therapeutics Ag Parg inhibitory compounds
TW202610628A (zh) * 2024-07-29 2026-03-16 大陸商海思科醫藥集團股份有限公司 磺醯胺化合物及其在醫藥上的應用
WO2026032385A1 (zh) * 2024-08-07 2026-02-12 上海亚虹医药科技有限公司 多聚adp核糖水解酶抑制剂及其医药用途
WO2026062066A1 (en) 2024-09-17 2026-03-26 Forx Therapeutics Ag Compounds inducing parg degradation

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Also Published As

Publication number Publication date
AU2023239344A1 (en) 2024-10-10
MX2024011545A (es) 2024-09-26
PL4496795T3 (pl) 2026-07-20
IL315722A (en) 2024-11-01
DOP2024000187A (es) 2024-12-30
EP4496795B1 (en) 2026-04-01
MA69135B1 (fr) 2026-07-31
EP4496795A1 (en) 2025-01-29
CN119255994A (zh) 2025-01-03
DK4496795T3 (da) 2026-05-04
US20230303556A1 (en) 2023-09-28
EP4775206A2 (en) 2026-07-15
TW202345809A (zh) 2023-12-01
KR20240165402A (ko) 2024-11-22
CO2024012798A2 (es) 2024-10-21
FI4496795T3 (fi) 2026-05-21
CR20240391A (es) 2024-11-05
HRP20260714T1 (hr) 2026-07-17
US20250376467A1 (en) 2025-12-11
WO2023183850A1 (en) 2023-09-28
AR128846A1 (es) 2024-06-19
JP7783436B2 (ja) 2025-12-09
CL2024002805A1 (es) 2025-05-09
JP2025512780A (ja) 2025-04-22
SMT202600201T1 (it) 2026-07-16
PT4496795T (pt) 2026-05-04
RS68230B1 (en) 2026-07-31
US12269820B2 (en) 2025-04-08
ES3070012T3 (en) 2026-06-11
PE20251690A1 (es) 2025-07-02
LT4496795T (lt) 2026-07-10

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