CA3243286A1 - L-NUCLEIC ACID APTAMER MIRROR IMAGE SELECTION - Google Patents
L-NUCLEIC ACID APTAMER MIRROR IMAGE SELECTIONInfo
- Publication number
- CA3243286A1 CA3243286A1 CA3243286A CA3243286A CA3243286A1 CA 3243286 A1 CA3243286 A1 CA 3243286A1 CA 3243286 A CA3243286 A CA 3243286A CA 3243286 A CA3243286 A CA 3243286A CA 3243286 A1 CA3243286 A1 CA 3243286A1
- Authority
- CA
- Canada
- Prior art keywords
- mirror
- nucleic acid
- image selection
- acid aptamers
- aptamers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C12N2330/31—Libraries, arrays
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263306139P | 2022-02-03 | 2022-02-03 | |
| US63/306,139 | 2022-02-03 | ||
| US202263311092P | 2022-02-17 | 2022-02-17 | |
| US63/311,092 | 2022-02-17 | ||
| PCT/IB2023/050908 WO2023148646A1 (en) | 2022-02-03 | 2023-02-02 | Mirror-image selection of l-nucleic acid aptamers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3243286A1 true CA3243286A1 (en) | 2023-08-10 |
Family
ID=85380927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3243286A Pending CA3243286A1 (en) | 2022-02-03 | 2023-02-02 | L-NUCLEIC ACID APTAMER MIRROR IMAGE SELECTION |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250027090A1 (https=) |
| EP (1) | EP4473115A1 (https=) |
| JP (1) | JP2025507269A (https=) |
| CN (1) | CN119013403A (https=) |
| AU (1) | AU2023216497A1 (https=) |
| CA (1) | CA3243286A1 (https=) |
| WO (1) | WO2023148646A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119757294B (zh) * | 2024-12-20 | 2025-08-29 | 厦门市亮惠诊断技术有限公司 | 一种用于d-乳酸高灵敏检测方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US20070141598A1 (en) * | 2005-02-09 | 2007-06-21 | Pacific Biosciences Of California, Inc. | Nucleotide Compositions and Uses Thereof |
| WO2013170963A2 (en) | 2012-05-16 | 2013-11-21 | Noxxon Pharma Ag | Enzymatic synthesis of l-nucleic acids |
| CN106467910A (zh) * | 2015-08-18 | 2017-03-01 | 清华大学 | L-dna/l-rna聚合酶及其应用 |
| TWI731028B (zh) * | 2016-01-22 | 2021-06-21 | 國立大學法人東京大學 | 用以篩選核酸適體之方法 |
| WO2019166457A1 (en) * | 2018-02-28 | 2019-09-06 | F. Hoffmann-La Roche Ag | Tagged nucleoside compounds useful for nanopore detection |
| CA3094598A1 (en) * | 2018-04-05 | 2019-10-10 | Tsinghua University | Methods of sequencing and producing nucleic acid sequences |
| WO2019236571A1 (en) | 2018-06-04 | 2019-12-12 | Chan Zuckerberg Biohub, Inc. | Compositions and methods involving non-natural aptamer libraries |
| CN111057132B (zh) * | 2019-10-16 | 2022-01-07 | 四川农业大学 | 牛病毒性腹泻病毒e0蛋白氨基酸及制备方法 |
-
2023
- 2023-02-02 AU AU2023216497A patent/AU2023216497A1/en active Pending
- 2023-02-02 EP EP23707167.5A patent/EP4473115A1/en active Pending
- 2023-02-02 WO PCT/IB2023/050908 patent/WO2023148646A1/en not_active Ceased
- 2023-02-02 CA CA3243286A patent/CA3243286A1/en active Pending
- 2023-02-02 CN CN202380032837.1A patent/CN119013403A/zh active Pending
- 2023-02-02 JP JP2024544827A patent/JP2025507269A/ja active Pending
-
2024
- 2024-07-28 US US18/786,501 patent/US20250027090A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025507269A (ja) | 2025-03-18 |
| EP4473115A1 (en) | 2024-12-11 |
| US20250027090A1 (en) | 2025-01-23 |
| AU2023216497A1 (en) | 2024-08-15 |
| CN119013403A (zh) | 2024-11-22 |
| WO2023148646A1 (en) | 2023-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A00 | Application filed |
Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A00-A101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION RECEIVED - PCT Effective date: 20240724 |
|
| MFA | Maintenance fee for application paid |
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| A15 | Pct application entered into the national or regional phase |
Free format text: ST27 STATUS EVENT CODE: A-1-1-A10-A15-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: NATIONAL ENTRY REQUIREMENTS DETERMINED COMPLIANT Effective date: 20240725 |
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| P18 | Priority claim added or amended |
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| U11 | Full renewal or maintenance fee paid |
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| A00 | Application filed |
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| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-P146 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: BSL VERIFIED - NO DEFECTS Effective date: 20260217 |