CA3242479A1 - Aminotetraline activators of serotonin receptors - Google Patents
Aminotetraline activators of serotonin receptorsInfo
- Publication number
- CA3242479A1 CA3242479A1 CA3242479A CA3242479A CA3242479A1 CA 3242479 A1 CA3242479 A1 CA 3242479A1 CA 3242479 A CA3242479 A CA 3242479A CA 3242479 A CA3242479 A CA 3242479A CA 3242479 A1 CA3242479 A1 CA 3242479A1
- Authority
- CA
- Canada
- Prior art keywords
- iii
- aminoteraline
- serotonin receptor
- receptor activators
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163294030P | 2021-12-27 | 2021-12-27 | |
| US63/294,030 | 2021-12-27 | ||
| PCT/US2022/082403 WO2023129909A1 (en) | 2021-12-27 | 2022-12-27 | Aminotetraline activators of serotonin receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3242479A1 true CA3242479A1 (en) | 2023-07-06 |
Family
ID=86898315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3242479A Pending CA3242479A1 (en) | 2021-12-27 | 2022-12-27 | Aminotetraline activators of serotonin receptors |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11827580B2 (enExample) |
| EP (1) | EP4457203A4 (enExample) |
| JP (1) | JP2024547131A (enExample) |
| AU (1) | AU2022425198A1 (enExample) |
| CA (1) | CA3242479A1 (enExample) |
| WO (1) | WO2023129909A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3519816A4 (en) | 2016-09-29 | 2020-05-06 | The Regents of the University of California | CONNECTIONS FOR INCREASING NEURONAL PLASTICITY |
| KR102946120B1 (ko) | 2019-02-27 | 2026-03-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클 |
| MX2023014630A (es) | 2021-06-08 | 2024-01-30 | Atai Therapeutics Inc | Activadores de dimetoxifenilalquilamina de receptores de serotonina. |
| IL313455A (en) | 2021-12-15 | 2024-08-01 | Delix Therapeutics Inc | Phenoxy and benzyloxy modified psychroplastogens and their uses |
| EP4457203A4 (en) * | 2021-12-27 | 2025-12-17 | Atai Therapeutics Inc | AMINOTETRALINE ACTIVATORS OF SEROTONIN RECEPTORS |
| WO2024124056A1 (en) * | 2022-12-07 | 2024-06-13 | Entheogenix Biosciences, Inc. | Novel sulfoximine activators of serotonin receptors |
| US12343319B2 (en) | 2023-05-01 | 2025-07-01 | Atai Therapeutics, Inc. | Compositions and methods for treatment of diseases and disorders |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6045180B2 (ja) * | 1977-05-17 | 1985-10-08 | 第一製薬株式会社 | ２−アミノテトラリン誘導体 |
| FR2691145A1 (fr) | 1992-05-18 | 1993-11-19 | Inst Nat Sante Rech Med | Nouveaux dérivés de la dihydroxybenzylamine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5807897A (en) * | 1996-03-01 | 1998-09-15 | Zeneca Limited | Aminotetralin derivative and compositions and method of use thereof |
| US6225352B1 (en) | 1996-08-14 | 2001-05-01 | Warner-Lambert Company | Low molecular weight dendritic compounds as pharmaceutical agents |
| US6201025B1 (en) | 1998-10-07 | 2001-03-13 | Ortho-Mcneil Pharmaceutical, Inc. | N-aralkylaminotetralins as ligands for the neuropeptide Y Y5 receptor |
| WO2001009120A1 (en) | 1999-07-28 | 2001-02-08 | Ortho-Mcneil Pharmaceutical, Inc. | Amine and amide derivatives as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders |
| DE10007948A1 (de) | 2000-02-22 | 2001-09-06 | Wella Ag | Mittel zur Färbung von Fasern |
| FR2809396B1 (fr) | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| DK1859798T3 (en) | 2001-03-29 | 2016-03-21 | Lilly Co Eli | N- (2-arylethyl) -BENZYLAMINER as antagonists of 5-HT6 receptor |
| US20050152858A1 (en) | 2003-07-11 | 2005-07-14 | Isp Investments Inc. | Solubilizing agents for active or functional organic compounds |
| US20070196395A1 (en) | 2003-12-12 | 2007-08-23 | Mackerell Alexander | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain |
| US7598255B2 (en) * | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
| US9101613B2 (en) | 2006-02-15 | 2015-08-11 | Neurim Pharmaceuticals (1991) Ltd. | Methods for treating neurological disease |
| BRPI0713736A2 (pt) * | 2006-06-20 | 2014-11-18 | Hoffmann La Roche | Derivados de tetralina e indano e emprego destes |
| US20080248511A1 (en) | 2007-03-26 | 2008-10-09 | Promega Corporation | Methods to quench light from optical reactions |
| US20080318957A1 (en) | 2007-05-11 | 2008-12-25 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
| JP5773877B2 (ja) | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
| WO2011047165A1 (en) | 2009-10-16 | 2011-04-21 | Southern Illinois University Edwardsville | Methods for treating memory impairment |
| EP2418196A1 (en) | 2010-07-29 | 2012-02-15 | IMTM GmbH | Dual alanyl-aminopeptidase and dipeptidyl-peptidase IV inhibitors |
| GB201409516D0 (en) | 2014-05-29 | 2014-07-16 | Randox Lab Ltd | Immunoassay for compounds of the NBOMe family |
| US10454900B2 (en) | 2015-09-25 | 2019-10-22 | Mcafee, Llc | Remote authentication and passwordless password reset |
| CN110177581B (zh) | 2016-11-16 | 2023-01-03 | 通用医疗公司 | 髓过氧化物酶显像剂 |
| WO2019084338A1 (en) | 2017-10-25 | 2019-05-02 | University Of South Florida | DRUG-INDUCED ACTIVATION OF THE REELIN SIGNALING SYSTEM |
| EP4417596B1 (en) | 2017-11-06 | 2026-04-29 | Acelot, Inc. | Small molecule drugs and related methods for treatment of diseases related to a-beta-42 oligomer formation |
| WO2019099402A1 (en) | 2017-11-14 | 2019-05-23 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods to treat infection |
| BR112020011189A2 (pt) | 2017-12-05 | 2020-11-17 | Sunovion Pharmaceuticals Inc. | misturas não racêmicas e usos das mesmas |
| AU2019324952B2 (en) | 2018-08-22 | 2024-10-24 | University Of Technology Sydney | NBOMe test |
| JP7731868B2 (ja) | 2019-08-02 | 2025-09-01 | エースロット，インコーポレイテッド | ＴＤＰ－４３、α－シヌクレイン、ハンチンチンタンパク質及びタウタンパク質のオリゴマー形成に関連する疾患を治療するための小分子薬物、並びに関連する方法 |
| AU2020386445B2 (en) | 2019-11-19 | 2025-12-18 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| US12534425B2 (en) | 2020-06-29 | 2026-01-27 | Gilgamesh Pharmaceuticals, Inc. | Phenalkylamines and methods of treating mood disorders |
| CN119285527A (zh) | 2020-06-30 | 2025-01-10 | 瑞安神经科学公司 | 色胺前药 |
| JP2024512796A (ja) | 2021-04-01 | 2024-03-19 | テラン バイオサイエンシーズ インク． | サイケデリック薬およびセロトニン受容体調節因子に関する方法と組成物 |
| EP4337220A4 (en) | 2021-05-11 | 2025-07-02 | Saint Josephs Univ | SELECTIVE, PARTIAL, AND POLARIZED 5-HT2A AGONISTS WITH UTILITY IN VARIOUS DISORDERS |
| WO2022261263A1 (en) | 2021-06-08 | 2022-12-15 | Gilgamesh Pharmaceuticals, Inc. | Methods of treating neuropsychiatric disorders |
| MX2023014630A (es) | 2021-06-08 | 2024-01-30 | Atai Therapeutics Inc | Activadores de dimetoxifenilalquilamina de receptores de serotonina. |
| CA3239571A1 (en) | 2021-12-15 | 2023-06-22 | Noel Aaron Powell | Fused pyrrolidine psychoplastogens and uses thereof |
| EP4457203A4 (en) | 2021-12-27 | 2025-12-17 | Atai Therapeutics Inc | AMINOTETRALINE ACTIVATORS OF SEROTONIN RECEPTORS |
| WO2024124056A1 (en) | 2022-12-07 | 2024-06-13 | Entheogenix Biosciences, Inc. | Novel sulfoximine activators of serotonin receptors |
| EP4637736A1 (en) | 2022-12-22 | 2025-10-29 | ATAI Therapeutics, Inc. | Prodrugs of dimethoxyphenylalkylamine activators of serotonin receptors |
| EP4637735A1 (en) | 2022-12-22 | 2025-10-29 | ATAI Therapeutics, Inc. | Dimethoxyphenyl heteroaromatic alkylamine activators of serotonin receptors |
| EP4680236A2 (en) | 2023-03-16 | 2026-01-21 | ATAI Therapeutics, Inc. | 3-alkylamine indole activators of serotonin receptors |
| US12343319B2 (en) | 2023-05-01 | 2025-07-01 | Atai Therapeutics, Inc. | Compositions and methods for treatment of diseases and disorders |
-
2022
- 2022-12-27 EP EP22917501.3A patent/EP4457203A4/en active Pending
- 2022-12-27 WO PCT/US2022/082403 patent/WO2023129909A1/en not_active Ceased
- 2022-12-27 AU AU2022425198A patent/AU2022425198A1/en active Pending
- 2022-12-27 US US18/146,785 patent/US11827580B2/en active Active
- 2022-12-27 CA CA3242479A patent/CA3242479A1/en active Pending
- 2022-12-27 JP JP2024538287A patent/JP2024547131A/ja active Pending
-
2023
- 2023-08-23 US US18/454,711 patent/US12344570B2/en active Active
-
2025
- 2025-05-21 US US19/215,023 patent/US20250282708A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230202965A1 (en) | 2023-06-29 |
| AU2022425198A1 (en) | 2024-07-18 |
| US20250282708A1 (en) | 2025-09-11 |
| EP4457203A4 (en) | 2025-12-17 |
| US12344570B2 (en) | 2025-07-01 |
| US11827580B2 (en) | 2023-11-28 |
| EP4457203A1 (en) | 2024-11-06 |
| JP2024547131A (ja) | 2024-12-26 |
| US20240300885A1 (en) | 2024-09-12 |
| WO2023129909A1 (en) | 2023-07-06 |
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