CA3232086A1 - Prodrugs of axitinib - Google Patents

Prodrugs of axitinib Download PDF

Info

Publication number
CA3232086A1
CA3232086A1 CA3232086A CA3232086A CA3232086A1 CA 3232086 A1 CA3232086 A1 CA 3232086A1 CA 3232086 A CA3232086 A CA 3232086A CA 3232086 A CA3232086 A CA 3232086A CA 3232086 A1 CA3232086 A1 CA 3232086A1
Authority
CA
Canada
Prior art keywords
compound
ch2oco
certain embodiments
pharmaceutical composition
condition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3232086A
Other languages
English (en)
French (fr)
Inventor
Peter Jarrett
Rami EL-HAYEK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ocular Therapeutix Inc
Original Assignee
Ocular Therapeutix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocular Therapeutix Inc filed Critical Ocular Therapeutix Inc
Publication of CA3232086A1 publication Critical patent/CA3232086A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3232086A 2021-10-15 2022-10-14 Prodrugs of axitinib Pending CA3232086A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163255998P 2021-10-15 2021-10-15
US63/255,998 2021-10-15
PCT/US2022/046750 WO2023064578A1 (en) 2021-10-15 2022-10-14 Prodrugs of axitinib

Publications (1)

Publication Number Publication Date
CA3232086A1 true CA3232086A1 (en) 2023-04-20

Family

ID=85987895

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3232086A Pending CA3232086A1 (en) 2021-10-15 2022-10-14 Prodrugs of axitinib

Country Status (8)

Country Link
US (1) US20250092013A1 (cg-RX-API-DMAC7.html)
EP (1) EP4416132A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024537839A (cg-RX-API-DMAC7.html)
CN (1) CN118119599A (cg-RX-API-DMAC7.html)
AU (1) AU2022362310A1 (cg-RX-API-DMAC7.html)
CA (1) CA3232086A1 (cg-RX-API-DMAC7.html)
MX (1) MX2024003968A (cg-RX-API-DMAC7.html)
WO (1) WO2023064578A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119947722A (zh) * 2022-10-14 2025-05-06 视尔普斯眼科公司 前药、制剂及其方法
JP2026520094A (ja) 2023-04-11 2026-06-22 オキュラ セラピューティクス，インコーポレイテッド アキシチニブ多形ｉｖを含む眼科インプラント

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5721949B2 (ja) * 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
WO2016183296A1 (en) * 2015-05-12 2016-11-17 Incept, Llc Drug delivery from hydrogels
TWI664965B (zh) * 2015-06-22 2019-07-11 新源生物科技股份有限公司 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法
CN106336397A (zh) * 2015-07-07 2017-01-18 郭明山 一种作为治疗眼科疾病的新化合物
WO2021035360A1 (en) * 2019-08-30 2021-03-04 Risen (Suzhou) Pharma Tech Co., Ltd. Prodrugs of the tyrosine kinase inhibitor for treating cancer
US12637441B2 (en) * 2019-08-30 2026-05-26 Risen (Suzhou) Pharma Tech Co., Ltd. Prodrugs of the tyrosine kinase inhibitor for treating cancer
CN112442010B (zh) * 2019-08-30 2023-10-03 润佳（苏州）医药科技有限公司 一类前药化合物及其在治疗癌症方面的应用
CA3171563A1 (en) * 2020-03-25 2021-09-30 Charles D. Blizzard Ocular implant containing a tyrosine kinase inhibitor

Also Published As

Publication number Publication date
MX2024003968A (es) 2024-04-29
EP4416132A4 (en) 2025-09-03
US20250092013A1 (en) 2025-03-20
EP4416132A1 (en) 2024-08-21
WO2023064578A1 (en) 2023-04-20
CN118119599A (zh) 2024-05-31
JP2024537839A (ja) 2024-10-16
AU2022362310A1 (en) 2024-04-11

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