JP2024537839A - アキシチニブのプロドラッグ - Google Patents

アキシチニブのプロドラッグ Download PDF

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Publication number
JP2024537839A
JP2024537839A JP2024519989A JP2024519989A JP2024537839A JP 2024537839 A JP2024537839 A JP 2024537839A JP 2024519989 A JP2024519989 A JP 2024519989A JP 2024519989 A JP2024519989 A JP 2024519989A JP 2024537839 A JP2024537839 A JP 2024537839A
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JP
Japan
Prior art keywords
compound
certain embodiments
pharmaceutical composition
ch2oco
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024519989A
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English (en)
Japanese (ja)
Other versions
JP2024537839A5 (cg-RX-API-DMAC7.html
Inventor
ジャレット，ピーター
エル－ハイエク，ラミ
Original Assignee
オキュラ セラピューティクス，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by オキュラ セラピューティクス，インコーポレイテッド filed Critical オキュラ セラピューティクス，インコーポレイテッド
Publication of JP2024537839A publication Critical patent/JP2024537839A/ja
Publication of JP2024537839A5 publication Critical patent/JP2024537839A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2024519989A 2021-10-15 2022-10-14 アキシチニブのプロドラッグ Pending JP2024537839A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163255998P 2021-10-15 2021-10-15
US63/255,998 2021-10-15
PCT/US2022/046750 WO2023064578A1 (en) 2021-10-15 2022-10-14 Prodrugs of axitinib

Publications (2)

Publication Number Publication Date
JP2024537839A true JP2024537839A (ja) 2024-10-16
JP2024537839A5 JP2024537839A5 (cg-RX-API-DMAC7.html) 2025-10-06

Family

ID=85987895

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024519989A Pending JP2024537839A (ja) 2021-10-15 2022-10-14 アキシチニブのプロドラッグ

Country Status (8)

Country Link
US (1) US20250092013A1 (cg-RX-API-DMAC7.html)
EP (1) EP4416132A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024537839A (cg-RX-API-DMAC7.html)
CN (1) CN118119599A (cg-RX-API-DMAC7.html)
AU (1) AU2022362310A1 (cg-RX-API-DMAC7.html)
CA (1) CA3232086A1 (cg-RX-API-DMAC7.html)
MX (1) MX2024003968A (cg-RX-API-DMAC7.html)
WO (1) WO2023064578A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119947722A (zh) * 2022-10-14 2025-05-06 视尔普斯眼科公司 前药、制剂及其方法
JP2026520094A (ja) 2023-04-11 2026-06-22 オキュラ セラピューティクス，インコーポレイテッド アキシチニブ多形ｉｖを含む眼科インプラント

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106336397A (zh) * 2015-07-07 2017-01-18 郭明山 一种作为治疗眼科疾病的新化合物
WO2021035360A1 (en) * 2019-08-30 2021-03-04 Risen (Suzhou) Pharma Tech Co., Ltd. Prodrugs of the tyrosine kinase inhibitor for treating cancer
CN112442010A (zh) * 2019-08-30 2021-03-05 润佳（苏州）医药科技有限公司 一类前药化合物及其在治疗癌症方面的应用
WO2021195163A1 (en) * 2020-03-25 2021-09-30 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5721949B2 (ja) * 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
WO2016183296A1 (en) * 2015-05-12 2016-11-17 Incept, Llc Drug delivery from hydrogels
TWI664965B (zh) * 2015-06-22 2019-07-11 新源生物科技股份有限公司 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法
US12637441B2 (en) * 2019-08-30 2026-05-26 Risen (Suzhou) Pharma Tech Co., Ltd. Prodrugs of the tyrosine kinase inhibitor for treating cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106336397A (zh) * 2015-07-07 2017-01-18 郭明山 一种作为治疗眼科疾病的新化合物
WO2021035360A1 (en) * 2019-08-30 2021-03-04 Risen (Suzhou) Pharma Tech Co., Ltd. Prodrugs of the tyrosine kinase inhibitor for treating cancer
CN112442010A (zh) * 2019-08-30 2021-03-05 润佳（苏州）医药科技有限公司 一类前药化合物及其在治疗癌症方面的应用
WO2021195163A1 (en) * 2020-03-25 2021-09-30 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor

Also Published As

Publication number Publication date
MX2024003968A (es) 2024-04-29
EP4416132A4 (en) 2025-09-03
US20250092013A1 (en) 2025-03-20
EP4416132A1 (en) 2024-08-21
CA3232086A1 (en) 2023-04-20
WO2023064578A1 (en) 2023-04-20
CN118119599A (zh) 2024-05-31
AU2022362310A1 (en) 2024-04-11

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