CA3230404A1 - Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof - Google Patents

Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof Download PDF

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Publication number
CA3230404A1
CA3230404A1 CA3230404A CA3230404A CA3230404A1 CA 3230404 A1 CA3230404 A1 CA 3230404A1 CA 3230404 A CA3230404 A CA 3230404A CA 3230404 A CA3230404 A CA 3230404A CA 3230404 A1 CA3230404 A1 CA 3230404A1
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Prior art keywords
nucleotides
strand
nucleotide
dsrna agent
antisense strand
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CA3230404A
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English (en)
French (fr)
Inventor
Jeffrey ZUBER
James D. Mcininch
Mark K. SCHLEGEL
Adam CASTORENO
Lucas BONDURANT
Dhaval OZA
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Publication of CA3230404A1 publication Critical patent/CA3230404A1/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/3527—Other alkyl chain
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CA3230404A 2021-08-31 2022-08-31 Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof Pending CA3230404A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163239271P 2021-08-31 2021-08-31
US63/239,271 2021-08-31
US202263341848P 2022-05-13 2022-05-13
US63/341,848 2022-05-13
PCT/US2022/075715 WO2023034837A2 (en) 2021-08-31 2022-08-31 Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof

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CA3230404A1 true CA3230404A1 (en) 2023-03-09

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US (2) US20250034567A1 (https=)
EP (1) EP4395790A2 (https=)
JP (1) JP2024538859A (https=)
KR (1) KR20240056561A (https=)
AU (1) AU2022339821A1 (https=)
CA (1) CA3230404A1 (https=)
IL (1) IL311030A (https=)
MX (1) MX2024002440A (https=)
TW (1) TW202325311A (https=)
WO (1) WO2023034837A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119278205A (zh) * 2022-04-07 2025-01-07 得克萨斯大学体系董事会 用靶向CIDEB的siRNA治疗肝病的组合物和方法
WO2024188164A1 (en) * 2023-03-10 2024-09-19 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of cell death inducing dffa like effector b (cideb)
AU2024243110A1 (en) * 2023-04-07 2025-11-06 Rona Bioscience, Limited Dsrna molecule for regulating expression of cideb mrna
WO2025178854A2 (en) * 2024-02-19 2025-08-28 Flagship Pioneering Innovations Vii, Llc Rnai agents targeting cideb and related methods

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