CA3226900A1 - Hypoallergenic peanut allergens, production and use thereof - Google Patents

Hypoallergenic peanut allergens, production and use thereof Download PDF

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Publication number
CA3226900A1
CA3226900A1 CA3226900A CA3226900A CA3226900A1 CA 3226900 A1 CA3226900 A1 CA 3226900A1 CA 3226900 A CA3226900 A CA 3226900A CA 3226900 A CA3226900 A CA 3226900A CA 3226900 A1 CA3226900 A1 CA 3226900A1
Authority
CA
Canada
Prior art keywords
ara
seq
variant
amino acid
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3226900A
Other languages
English (en)
French (fr)
Inventor
Yanay OFRAN
Moshe BEN DAVID
Orly MARCU GARBER
Si NAFTALY KIROS
Gil DIAMANT
Almog BREGMAN COHEN
Maayan KORMAN
Anna CHUPRIN
Zohar BIRON SOREK
Lior ROSENFELD SHLAMKOVICH
Etai ROTEM
Yair GAT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ukko Inc
Original Assignee
Ukko Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ukko Inc filed Critical Ukko Inc
Publication of CA3226900A1 publication Critical patent/CA3226900A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3226900A 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof Pending CA3226900A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202163228606P 2021-08-03 2021-08-03
US202163228604P 2021-08-03 2021-08-03
US63/228,606 2021-08-03
US63/228,604 2021-08-03
US202163284108P 2021-11-30 2021-11-30
US63/284,108 2021-11-30
US202163292441P 2021-12-22 2021-12-22
US63/292,441 2021-12-22
US202263311117P 2022-02-17 2022-02-17
US63/311,117 2022-02-17
US202263319393P 2022-03-14 2022-03-14
US202263319394P 2022-03-14 2022-03-14
US63/319,393 2022-03-14
US63/319,394 2022-03-14
PCT/IB2022/057144 WO2023012652A2 (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof

Publications (1)

Publication Number Publication Date
CA3226900A1 true CA3226900A1 (en) 2023-02-09

Family

ID=85155450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3226900A Pending CA3226900A1 (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof

Country Status (6)

Country Link
US (2) US20240390485A1 (https=)
EP (1) EP4380957A4 (https=)
JP (1) JP2024530926A (https=)
AU (1) AU2022323847A1 (https=)
CA (1) CA3226900A1 (https=)
WO (1) WO2023012652A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024178329A2 (en) * 2023-02-23 2024-08-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mutant ara h 2 and ara h 6 proteins and uses thereof
AU2024305143A1 (en) 2023-06-12 2026-01-08 Desentum Oy Hypoallergenic variants of major peanut allergen, ara h 2
WO2026080920A1 (en) 2024-10-13 2026-04-16 Ukko Inc. Mrna vaccine for peanut allergy treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002306850A1 (en) * 2001-03-16 2002-10-03 Panacea Pharmaceuticals Methods and reagents for decreasing clinical reaction to allergy
WO2005121166A1 (en) * 2004-06-10 2005-12-22 Monash University Novel immunointeractive molecules and uses thereof
EP2664624A1 (en) * 2012-05-15 2013-11-20 Biomay Ag Allergen variants
EP3563159A1 (en) * 2016-12-29 2019-11-06 Ukko Inc. Methods for identifying and de-epitoping allergenic polypeptides
US12398195B2 (en) * 2018-05-15 2025-08-26 Immunomic Therapeutics, Inc. Lamp constructs comprising allergens

Also Published As

Publication number Publication date
EP4380957A2 (en) 2024-06-12
JP2024530926A (ja) 2024-08-27
WO2023012652A2 (en) 2023-02-09
WO2023012652A3 (en) 2023-04-06
EP4380957A4 (en) 2025-09-03
US20240117020A1 (en) 2024-04-11
AU2022323847A1 (en) 2024-02-15
US20240390485A1 (en) 2024-11-28

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