CA3220629A1 - Methods for detecting cm-tma biomarkers - Google Patents

Methods for detecting cm-tma biomarkers Download PDF

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Publication number
CA3220629A1
CA3220629A1 CA3220629A CA3220629A CA3220629A1 CA 3220629 A1 CA3220629 A1 CA 3220629A1 CA 3220629 A CA3220629 A CA 3220629A CA 3220629 A CA3220629 A CA 3220629A CA 3220629 A1 CA3220629 A1 CA 3220629A1
Authority
CA
Canada
Prior art keywords
creatinine
sc5b9
cystatin
plasma
complement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3220629A
Other languages
English (en)
French (fr)
Inventor
Tobin J. CAMMETT
Susan Faas Mcknight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexion Pharmaceuticals Inc
Original Assignee
Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharmaceuticals Inc filed Critical Alexion Pharmaceuticals Inc
Publication of CA3220629A1 publication Critical patent/CA3220629A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3220629A 2021-05-28 2022-05-26 Methods for detecting cm-tma biomarkers Pending CA3220629A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163194704P 2021-05-28 2021-05-28
US63/194,704 2021-05-28
US202163272033P 2021-10-26 2021-10-26
US63/272,033 2021-10-26
PCT/US2022/031062 WO2022251446A1 (en) 2021-05-28 2022-05-26 Methods for detecting cm-tma biomarkers

Publications (1)

Publication Number Publication Date
CA3220629A1 true CA3220629A1 (en) 2022-12-01

Family

ID=82214465

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3220629A Pending CA3220629A1 (en) 2021-05-28 2022-05-26 Methods for detecting cm-tma biomarkers

Country Status (5)

Country Link
US (1) US20250199013A1 (https=)
EP (1) EP4348263A1 (https=)
JP (1) JP2024520497A (https=)
CA (1) CA3220629A1 (https=)
WO (1) WO2022251446A1 (https=)

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Also Published As

Publication number Publication date
JP2024520497A (ja) 2024-05-24
WO2022251446A1 (en) 2022-12-01
US20250199013A1 (en) 2025-06-19
EP4348263A1 (en) 2024-04-10

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