CA3202354A1 - Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators - Google Patents

Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators Download PDF

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Publication number
CA3202354A1
CA3202354A1 CA3202354A CA3202354A CA3202354A1 CA 3202354 A1 CA3202354 A1 CA 3202354A1 CA 3202354 A CA3202354 A CA 3202354A CA 3202354 A CA3202354 A CA 3202354A CA 3202354 A1 CA3202354 A1 CA 3202354A1
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CA
Canada
Prior art keywords
compound
formula
amount
less
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3202354A
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English (en)
French (fr)
Inventor
Jeffrey Mark Dener
Hazel Joan HUNT
Travis Lemons
Gary Reid
Kilian GARREC
Thomas C. Stephens
Adam Daisuke Gammack YAMAGATA
Yunguo LU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corcept Therapeutics Inc
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Corcept Therapeutics Inc
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Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of CA3202354A1 publication Critical patent/CA3202354A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3202354A 2020-12-25 2021-12-22 Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators Pending CA3202354A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/139524 2020-12-25
PCT/CN2020/139524 WO2022134033A1 (en) 2020-12-25 2020-12-25 Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
PCT/US2021/064947 WO2022140600A1 (en) 2020-12-25 2021-12-22 Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
CA3202354A1 true CA3202354A1 (en) 2022-06-30

Family

ID=82157262

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3202354A Pending CA3202354A1 (en) 2020-12-25 2021-12-22 Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Country Status (10)

Country Link
US (2) US12152028B2 (enExample)
EP (1) EP4267577A4 (enExample)
JP (1) JP7720914B2 (enExample)
KR (1) KR20230124985A (enExample)
CN (1) CN116867780A (enExample)
AU (2) AU2021410756B2 (enExample)
CA (1) CA3202354A1 (enExample)
IL (1) IL304005A (enExample)
MX (1) MX2023007404A (enExample)
WO (2) WO2022134033A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022134033A1 (en) 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
WO2024077169A1 (en) 2022-10-06 2024-04-11 Corcept Therapeutics Incorporated Formulations of glucocorticoid receptor modulators

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Also Published As

Publication number Publication date
AU2021410756A1 (en) 2023-07-06
EP4267577A4 (en) 2024-11-27
WO2022140600A1 (en) 2022-06-30
JP2024501956A (ja) 2024-01-17
CN116867780A (zh) 2023-10-10
US12152028B2 (en) 2024-11-26
AU2021410756A9 (en) 2024-09-12
MX2023007404A (es) 2023-08-21
US20220227753A1 (en) 2022-07-21
JP7720914B2 (ja) 2025-08-08
US20250145620A1 (en) 2025-05-08
KR20230124985A (ko) 2023-08-28
AU2025203341B2 (en) 2026-03-05
EP4267577A1 (en) 2023-11-01
IL304005A (en) 2023-08-01
AU2025203341A1 (en) 2025-05-29
WO2022134033A1 (en) 2022-06-30
AU2021410756B2 (en) 2025-02-13

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